The multikinase inhibitor EC‐70124 synergistically increased the antitumor activity of doxorubicin in sarcomas

Cytotoxic drugs like doxorubicin remain as the most utilized agents in sarcoma treatment. However, advanced sarcomas are often resistant, thus stressing the need for new therapies aimed to overcome this resistance. Multikinase inhibitors provide an efficient way to target several pro‐tumorigenic pat...

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Veröffentlicht in:	International journal of cancer 2019-07, Vol.145 (1), p.254-266
Hauptverfasser:	Estupiñan, Oscar, Santos, Laura, Rodriguez, Aida, Fernandez‐Nevado, Lucia, Costales, Paula, Perez‐Escuredo, Jhudit, Hermosilla, Maria Ana, Oro, Patricia, Rey, Veronica, Tornin, Juan, Allonca, Eva, Fernandez‐Garcia, Maria Teresa, Alvarez‐Fernandez, Carlos, Braña, Alejandro, Astudillo, Aurora, Menendez, Sofia T, Moris, Francisco, Rodriguez, Rene
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase ABC pumps AKT protein Antitumor activity Apoptosis Cancer Cell culture Cell cycle Combined treatment Cytotoxicity Càncer DNA damage Doxorubicin Drug resistance EC‐70124 Enginyeria dels materials indolocarbazole Kinases Medical research mTOR myxoid liposarcoma Phosphorylation Sarcoma TOR protein Tractament Treatment Tumor cell lines Tumors Àrees temàtiques de la UPC
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