Evaluation of Objective Vitritis Grading Method Using Optical Coherence Tomography: Influence of Phakic Status and Previous Vitrectomy
Purpose To evaluate a proposed method for objective measurement of vitreous inflammation using a spectral-domain optical coherence tomography (SD OCT) device in a large cohort of uveitis eyes, including pseudophakic eyes and vitrectomized eyes. Design Retrospective, observational cohort study. Metho...
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| Veröffentlicht in: | American journal of ophthalmology 2016-01, Vol.161, p.172-180.e4 |
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| creator | Zarranz-Ventura, Javier Keane, Pearse A Sim, Dawn A Llorens, Victor Tufail, Adnan Sadda, Srinivas R Dick, Andrew D Lee, Richard W Pavesio, Carlos Denniston, Alastair K Adan, Alfredo |
| description | Purpose To evaluate a proposed method for objective measurement of vitreous inflammation using a spectral-domain optical coherence tomography (SD OCT) device in a large cohort of uveitis eyes, including pseudophakic eyes and vitrectomized eyes. Design Retrospective, observational cohort study. Methods One hundred five uveitis eyes (105 patients) with different vitreous haze score grades according to standardized protocols and corresponding SD OCT images (Cirrus HD-OCT; Carl Zeiss Meditec, Dublin, California, USA) were included. Clinical data recorded included phakic status, previous vitreoretinal surgery, and anterior chamber (AC) cells and flare. SD OCT images were analyzed using custom software that provided absolute measurements of vitreous (VIT) and retinal pigment epithelium (RPE) signal intensities, which were compared to generate a relative optical density ratio with arbitrary units (VIT/RPE-relative intensity) and compared to VHS. Results VIT/RPE-relative intensity showed a significant positive correlation with vitreous haze score ( r = 0.535, P < .001) that remained significant after adjusting for factors governing media clarity, such as AC cells, AC flare, and phakic status (R2 -adjusted = 0.424, P < .001). Significant differences were also observed between the different vitreous haze score groups ( P < .001). Preliminary observation did not observe differences in VIT/RPE-relative intensity values between phakic and pseudophakic eyes (0.3522 vs 0.3577, P = .48) and between nonvitrectomized and vitrectomized eyes (0.3540 vs 0.3580, P = .52), overall and respectively for each vitreous haze score subgroup. Conclusions VIT/RPE-relative intensity values provide objective measurements of vitreous inflammation employing an SD OCT device. Phakic status and previous vitrectomy surgery do not appear to influence these values, although these preliminary findings need validation in future studies. |
| doi_str_mv | 10.1016/j.ajo.2015.10.009 |
| format | Article |
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Design Retrospective, observational cohort study. Methods One hundred five uveitis eyes (105 patients) with different vitreous haze score grades according to standardized protocols and corresponding SD OCT images (Cirrus HD-OCT; Carl Zeiss Meditec, Dublin, California, USA) were included. Clinical data recorded included phakic status, previous vitreoretinal surgery, and anterior chamber (AC) cells and flare. SD OCT images were analyzed using custom software that provided absolute measurements of vitreous (VIT) and retinal pigment epithelium (RPE) signal intensities, which were compared to generate a relative optical density ratio with arbitrary units (VIT/RPE-relative intensity) and compared to VHS. Results VIT/RPE-relative intensity showed a significant positive correlation with vitreous haze score ( r = 0.535, P < .001) that remained significant after adjusting for factors governing media clarity, such as AC cells, AC flare, and phakic status (R2 -adjusted = 0.424, P < .001). Significant differences were also observed between the different vitreous haze score groups ( P < .001). Preliminary observation did not observe differences in VIT/RPE-relative intensity values between phakic and pseudophakic eyes (0.3522 vs 0.3577, P = .48) and between nonvitrectomized and vitrectomized eyes (0.3540 vs 0.3580, P = .52), overall and respectively for each vitreous haze score subgroup. Conclusions VIT/RPE-relative intensity values provide objective measurements of vitreous inflammation employing an SD OCT device. Phakic status and previous vitrectomy surgery do not appear to influence these values, although these preliminary findings need validation in future studies.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/j.ajo.2015.10.009</identifier><identifier>PMID: 26476212</identifier><identifier>CODEN: AJOPAA</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Anterior Chamber - pathology ; Cirurgia ocular ; Eye Diseases - classification ; Eye Diseases - diagnosis ; Eye surgery ; FDA approval ; Female ; Humans ; Inflammation ; Inflammation - classification ; Inflammation - diagnosis ; Lens, Crystalline - physiopathology ; Macular degeneration ; Male ; Middle Aged ; Oftalmopaties ; Ophthalmology ; Ophthalmopathies ; Patients ; Pseudophakia - physiopathology ; Quantitative analysis ; Retinal Pigment Epithelium - pathology ; Retrospective Studies ; Surgery ; Tomography, Optical Coherence - methods ; Uveitis - complications ; Visual Acuity ; Vitrectomy ; Vitreous Body - pathology</subject><ispartof>American journal of ophthalmology, 2016-01, Vol.161, p.172-180.e4</ispartof><rights>Elsevier Inc.</rights><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Jan 2016</rights><rights>cc-by-nc-nd (c) Elsevier B.V., 2016 info:eu-repo/semantics/openAccess <a href="http://creativecommons.org/licenses/by-nc-nd/3.0/es">http://creativecommons.org/licenses/by-nc-nd/3.0/es</a></rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c591t-bd8479f0041797cdb2a8eaa230946a7c293b1e16bb38e2db3370ad96273e00793</citedby><cites>FETCH-LOGICAL-c591t-bd8479f0041797cdb2a8eaa230946a7c293b1e16bb38e2db3370ad96273e00793</cites><orcidid>0000-0003-2338-8143</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajo.2015.10.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,26974,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26476212$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zarranz-Ventura, Javier</creatorcontrib><creatorcontrib>Keane, Pearse A</creatorcontrib><creatorcontrib>Sim, Dawn A</creatorcontrib><creatorcontrib>Llorens, Victor</creatorcontrib><creatorcontrib>Tufail, Adnan</creatorcontrib><creatorcontrib>Sadda, Srinivas R</creatorcontrib><creatorcontrib>Dick, Andrew D</creatorcontrib><creatorcontrib>Lee, Richard W</creatorcontrib><creatorcontrib>Pavesio, Carlos</creatorcontrib><creatorcontrib>Denniston, Alastair K</creatorcontrib><creatorcontrib>Adan, Alfredo</creatorcontrib><creatorcontrib>EQUATOR Study Group</creatorcontrib><title>Evaluation of Objective Vitritis Grading Method Using Optical Coherence Tomography: Influence of Phakic Status and Previous Vitrectomy</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>Purpose To evaluate a proposed method for objective measurement of vitreous inflammation using a spectral-domain optical coherence tomography (SD OCT) device in a large cohort of uveitis eyes, including pseudophakic eyes and vitrectomized eyes. Design Retrospective, observational cohort study. Methods One hundred five uveitis eyes (105 patients) with different vitreous haze score grades according to standardized protocols and corresponding SD OCT images (Cirrus HD-OCT; Carl Zeiss Meditec, Dublin, California, USA) were included. Clinical data recorded included phakic status, previous vitreoretinal surgery, and anterior chamber (AC) cells and flare. SD OCT images were analyzed using custom software that provided absolute measurements of vitreous (VIT) and retinal pigment epithelium (RPE) signal intensities, which were compared to generate a relative optical density ratio with arbitrary units (VIT/RPE-relative intensity) and compared to VHS. Results VIT/RPE-relative intensity showed a significant positive correlation with vitreous haze score ( r = 0.535, P < .001) that remained significant after adjusting for factors governing media clarity, such as AC cells, AC flare, and phakic status (R2 -adjusted = 0.424, P < .001). Significant differences were also observed between the different vitreous haze score groups ( P < .001). Preliminary observation did not observe differences in VIT/RPE-relative intensity values between phakic and pseudophakic eyes (0.3522 vs 0.3577, P = .48) and between nonvitrectomized and vitrectomized eyes (0.3540 vs 0.3580, P = .52), overall and respectively for each vitreous haze score subgroup. Conclusions VIT/RPE-relative intensity values provide objective measurements of vitreous inflammation employing an SD OCT device. Phakic status and previous vitrectomy surgery do not appear to influence these values, although these preliminary findings need validation in future studies.</description><subject>Adult</subject><subject>Anterior Chamber - pathology</subject><subject>Cirurgia ocular</subject><subject>Eye Diseases - classification</subject><subject>Eye Diseases - diagnosis</subject><subject>Eye surgery</subject><subject>FDA approval</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - classification</subject><subject>Inflammation - diagnosis</subject><subject>Lens, Crystalline - physiopathology</subject><subject>Macular degeneration</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oftalmopaties</subject><subject>Ophthalmology</subject><subject>Ophthalmopathies</subject><subject>Patients</subject><subject>Pseudophakia - physiopathology</subject><subject>Quantitative analysis</subject><subject>Retinal Pigment Epithelium - pathology</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Uveitis - complications</subject><subject>Visual Acuity</subject><subject>Vitrectomy</subject><subject>Vitreous Body - pathology</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>XX2</sourceid><recordid>eNp9Uk1v1DAUjBCILoUfwAVZ4sIliz-SOAYJCa3aUqloK7XlajnOS9dpEi-2s9L-AX53bbZQ1AMHy5qnmfc8npdlbwleEkyqj_1S9XZJMSkjXmIsnmULUnORk1qQ59kCY0xzwURxlL3yvo-w4gV_mR3RquAVJXSR_TrZqWFWwdgJ2Q6tmx50MDtAP0xwJhiPzpxqzXSLvkPY2Bbd-ATW22C0GtDKbsDBpAFd29HeOrXd7D-h86kb5t_V2PJyo-6MRldBhdkjNbXo0sHO2AjSjDjOjvvX2YtODR7ePNzH2c3pyfXqW36xPjtffb3IdSlIyJu2LrjoMC4IF1y3DVU1KEUZFkWluKaCNQRI1TSsBto2jHGsWlFRzgBjLthxRg59tZ-1jMPBaRWkVeYRpEMxp5IVouJ11Hw4aLbO_pzBBzkar2EY1ATRhSS8JEKUVNBIff-E2tvZTdFRYjFalbxi_zzCWe8ddHLrzKjcXhIsU7CylzFYmYJNpRhs1Lx76Dw3I7R_FX-SjITPBwLE79sZcNJrkzJoTfpj2Vrz3_Zfnqj1YKYU8R3swT-6kJ5KLK_SZqXFImXcKRZN3QMo2chn</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Zarranz-Ventura, Javier</creator><creator>Keane, Pearse A</creator><creator>Sim, Dawn A</creator><creator>Llorens, Victor</creator><creator>Tufail, Adnan</creator><creator>Sadda, Srinivas R</creator><creator>Dick, Andrew D</creator><creator>Lee, Richard W</creator><creator>Pavesio, Carlos</creator><creator>Denniston, Alastair K</creator><creator>Adan, Alfredo</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>XX2</scope><orcidid>https://orcid.org/0000-0003-2338-8143</orcidid></search><sort><creationdate>20160101</creationdate><title>Evaluation of Objective Vitritis Grading Method Using Optical Coherence Tomography: Influence of Phakic Status and Previous Vitrectomy</title><author>Zarranz-Ventura, Javier ; Keane, Pearse A ; Sim, Dawn A ; Llorens, Victor ; Tufail, Adnan ; Sadda, Srinivas R ; Dick, Andrew D ; Lee, Richard W ; Pavesio, Carlos ; Denniston, Alastair K ; Adan, Alfredo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c591t-bd8479f0041797cdb2a8eaa230946a7c293b1e16bb38e2db3370ad96273e00793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Anterior Chamber - pathology</topic><topic>Cirurgia ocular</topic><topic>Eye Diseases - classification</topic><topic>Eye Diseases - diagnosis</topic><topic>Eye surgery</topic><topic>FDA approval</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - classification</topic><topic>Inflammation - diagnosis</topic><topic>Lens, Crystalline - physiopathology</topic><topic>Macular degeneration</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oftalmopaties</topic><topic>Ophthalmology</topic><topic>Ophthalmopathies</topic><topic>Patients</topic><topic>Pseudophakia - physiopathology</topic><topic>Quantitative analysis</topic><topic>Retinal Pigment Epithelium - pathology</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Tomography, Optical Coherence - methods</topic><topic>Uveitis - complications</topic><topic>Visual Acuity</topic><topic>Vitrectomy</topic><topic>Vitreous Body - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zarranz-Ventura, Javier</creatorcontrib><creatorcontrib>Keane, Pearse A</creatorcontrib><creatorcontrib>Sim, Dawn A</creatorcontrib><creatorcontrib>Llorens, Victor</creatorcontrib><creatorcontrib>Tufail, Adnan</creatorcontrib><creatorcontrib>Sadda, Srinivas R</creatorcontrib><creatorcontrib>Dick, Andrew D</creatorcontrib><creatorcontrib>Lee, Richard W</creatorcontrib><creatorcontrib>Pavesio, Carlos</creatorcontrib><creatorcontrib>Denniston, Alastair K</creatorcontrib><creatorcontrib>Adan, Alfredo</creatorcontrib><creatorcontrib>EQUATOR Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Recercat</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zarranz-Ventura, Javier</au><au>Keane, Pearse A</au><au>Sim, Dawn A</au><au>Llorens, Victor</au><au>Tufail, Adnan</au><au>Sadda, Srinivas R</au><au>Dick, Andrew D</au><au>Lee, Richard W</au><au>Pavesio, Carlos</au><au>Denniston, Alastair K</au><au>Adan, Alfredo</au><aucorp>EQUATOR Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Objective Vitritis Grading Method Using Optical Coherence Tomography: Influence of Phakic Status and Previous Vitrectomy</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>161</volume><spage>172</spage><epage>180.e4</epage><pages>172-180.e4</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><coden>AJOPAA</coden><abstract>Purpose To evaluate a proposed method for objective measurement of vitreous inflammation using a spectral-domain optical coherence tomography (SD OCT) device in a large cohort of uveitis eyes, including pseudophakic eyes and vitrectomized eyes. Design Retrospective, observational cohort study. Methods One hundred five uveitis eyes (105 patients) with different vitreous haze score grades according to standardized protocols and corresponding SD OCT images (Cirrus HD-OCT; Carl Zeiss Meditec, Dublin, California, USA) were included. Clinical data recorded included phakic status, previous vitreoretinal surgery, and anterior chamber (AC) cells and flare. SD OCT images were analyzed using custom software that provided absolute measurements of vitreous (VIT) and retinal pigment epithelium (RPE) signal intensities, which were compared to generate a relative optical density ratio with arbitrary units (VIT/RPE-relative intensity) and compared to VHS. Results VIT/RPE-relative intensity showed a significant positive correlation with vitreous haze score ( r = 0.535, P < .001) that remained significant after adjusting for factors governing media clarity, such as AC cells, AC flare, and phakic status (R2 -adjusted = 0.424, P < .001). Significant differences were also observed between the different vitreous haze score groups ( P < .001). Preliminary observation did not observe differences in VIT/RPE-relative intensity values between phakic and pseudophakic eyes (0.3522 vs 0.3577, P = .48) and between nonvitrectomized and vitrectomized eyes (0.3540 vs 0.3580, P = .52), overall and respectively for each vitreous haze score subgroup. Conclusions VIT/RPE-relative intensity values provide objective measurements of vitreous inflammation employing an SD OCT device. Phakic status and previous vitrectomy surgery do not appear to influence these values, although these preliminary findings need validation in future studies.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26476212</pmid><doi>10.1016/j.ajo.2015.10.009</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2338-8143</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Anterior Chamber - pathology Cirurgia ocular Eye Diseases - classification Eye Diseases - diagnosis Eye surgery FDA approval Female Humans Inflammation Inflammation - classification Inflammation - diagnosis Lens, Crystalline - physiopathology Macular degeneration Male Middle Aged Oftalmopaties Ophthalmology Ophthalmopathies Patients Pseudophakia - physiopathology Quantitative analysis Retinal Pigment Epithelium - pathology Retrospective Studies Surgery Tomography, Optical Coherence - methods Uveitis - complications Visual Acuity Vitrectomy Vitreous Body - pathology |
| title | Evaluation of Objective Vitritis Grading Method Using Optical Coherence Tomography: Influence of Phakic Status and Previous Vitrectomy |
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