Musculoskeletal senescence: a moving target ready to be eliminated

•Cellular senescence drives age-related decline of the musculoskeletal system.•The Senescence Associated Secretory Phenotype (SASP) can chronically impair stem cell function.•The SASP can attenuate tissue regeneration in muscle, bone and cartilage during aging.•The SASP disturbs the balance between...

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Veröffentlicht in:	Current opinion in pharmacology 2018-06, Vol.40, p.147-155
Hauptverfasser:	Baar, Marjolein P, Perdiguero, Eusebio, Muñoz-Cánoves, Pura, de Keizer, Peter LJ
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Aparell locomotor Apoptosis - drug effects Bone and Bones - drug effects Bone and Bones - metabolism Bone and Bones - pathology Bone and Bones - physiopathology Bone Remodeling - drug effects Cartilage - drug effects Cartilage - metabolism Cartilage - pathology Cartilage - physiopathology Cellular Senescence - drug effects Chondrogenesis - drug effects Drug Design Envelliment Humans Molecular Targeted Therapy - methods Muscle Development - drug effects Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscle, Skeletal - physiopathology Musculoskeletal Diseases - drug therapy Musculoskeletal Diseases - metabolism Musculoskeletal Diseases - pathology Musculoskeletal Diseases - physiopathology Musculoskeletal System - drug effects Musculoskeletal System - metabolism Musculoskeletal System - pathology Musculoskeletal System - physiopathology Persones grans dependents Regeneration - drug effects Signal Transduction - drug effects
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