Human Papillomavirus Infection in HIV-1 Infected Women in Catalonia (Spain): Implications for Prevention of Cervical Cancer
Background High-risk human Papillomavirus infection is a necessary factor for cervical squamous intraepithelial lesions and invasive cervical cancer. In HIV-1-infected women, HPV infection is more prevalent and a higher risk of cervical cancer has been identified. We aimed to calculate the prevalenc...
Gespeichert in:
| Veröffentlicht in: | PloS one 2012-10 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | PloS one |
| container_volume | |
| creator | Stuardo, Valeria Agustí, Cristina Godínez, José M Montoliu, Alexandra Torné Bladé, Aureli Tarrats, Antoni Alcalde, Carme Martín, Dolores Fernández-Montoli, Eulalia Vanrell, Cristina Solé, Josefa Canet, Yolanda Marqueta, José M Mohamed, Jadiyettu Cuenca, Isabel Lonca, Montserrat Sirera, Guillem Ferrer, Elena Domingo, Pere Lloveras Rubio, Belén Miró Meda, José M Sanjosé Llongueras, Silvia de Casabona, Jordi |
| description | Background High-risk human Papillomavirus infection is a necessary factor for cervical squamous intraepithelial lesions and invasive cervical cancer. In HIV-1-infected women, HPV infection is more prevalent and a higher risk of cervical cancer has been identified. We aimed to calculate the prevalence of infection by HR-HPV, determine the factors associated with this infection and abnormal cytology findings and to describe the history of cervical cancer screening in HIV-1-infected women. Methods We enrolled 479 HIV-1-infected women from the PISCIS cohort. Each patient underwent a gynecological check-up, PAP smear, HPV AND Hybrid capture, HPV genotyping, and colposcopy and biopsy, if necessary. We applied questionnaires to obtain information on sociodemographic, behavioral, clinical, and cervical screening variables. We present a cross-sectional analysis. Results Median age was 42 years. The prevalence of HR-HPV infection was 33.2% and that of high-grade squamous intraepithelial lesions (HSIL) was 3.8%. The most common genotypes were 16(23%), 53(20.3%), and 52(16.2%). The factor associated with HR-HPV infection was age 10,000copies/mL versus |
| format | Article |
| fullrecord | <record><control><sourceid>csuc</sourceid><recordid>TN_cdi_csuc_recercat_oai_recercat_cat_2072_332792</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>oai_recercat_cat_2072_332792</sourcerecordid><originalsourceid>FETCH-csuc_recercat_oai_recercat_cat_2072_3327923</originalsourceid><addsrcrecordid>eNqdjEsLwjAQhIMoWB__YY96KLQJ1se1KO1NUPRYlriFSJqUpO3FP28VQc8elt2dmW8GLIi3gocJj8Tw5x6ziff3KFqJTZIE7JG1FRo4Yq20thV2yrUeclOSbJQ1oAxk-SWMPxLd4GoreuspNqitUQiLU43KLHeQV7VWEl-kh9I6ODrqyLybbAkpua63dY8aSW7GRiVqT_PPnrL4sD-nWSh9KwtHfaTvKiyq7_MaHq15IQRfb7n4h3kCVCtZQg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Human Papillomavirus Infection in HIV-1 Infected Women in Catalonia (Spain): Implications for Prevention of Cervical Cancer</title><source>DOAJ Directory of Open Access Journals</source><source>Recercat</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Stuardo, Valeria ; Agustí, Cristina ; Godínez, José M ; Montoliu, Alexandra ; Torné Bladé, Aureli ; Tarrats, Antoni ; Alcalde, Carme ; Martín, Dolores ; Fernández-Montoli, Eulalia ; Vanrell, Cristina ; Solé, Josefa ; Canet, Yolanda ; Marqueta, José M ; Mohamed, Jadiyettu ; Cuenca, Isabel ; Lonca, Montserrat ; Sirera, Guillem ; Ferrer, Elena ; Domingo, Pere ; Lloveras Rubio, Belén ; Miró Meda, José M ; Sanjosé Llongueras, Silvia de ; Casabona, Jordi</creator><creatorcontrib>Stuardo, Valeria ; Agustí, Cristina ; Godínez, José M ; Montoliu, Alexandra ; Torné Bladé, Aureli ; Tarrats, Antoni ; Alcalde, Carme ; Martín, Dolores ; Fernández-Montoli, Eulalia ; Vanrell, Cristina ; Solé, Josefa ; Canet, Yolanda ; Marqueta, José M ; Mohamed, Jadiyettu ; Cuenca, Isabel ; Lonca, Montserrat ; Sirera, Guillem ; Ferrer, Elena ; Domingo, Pere ; Lloveras Rubio, Belén ; Miró Meda, José M ; Sanjosé Llongueras, Silvia de ; Casabona, Jordi</creatorcontrib><description>Background High-risk human Papillomavirus infection is a necessary factor for cervical squamous intraepithelial lesions and invasive cervical cancer. In HIV-1-infected women, HPV infection is more prevalent and a higher risk of cervical cancer has been identified. We aimed to calculate the prevalence of infection by HR-HPV, determine the factors associated with this infection and abnormal cytology findings and to describe the history of cervical cancer screening in HIV-1-infected women. Methods We enrolled 479 HIV-1-infected women from the PISCIS cohort. Each patient underwent a gynecological check-up, PAP smear, HPV AND Hybrid capture, HPV genotyping, and colposcopy and biopsy, if necessary. We applied questionnaires to obtain information on sociodemographic, behavioral, clinical, and cervical screening variables. We present a cross-sectional analysis. Results Median age was 42 years. The prevalence of HR-HPV infection was 33.2% and that of high-grade squamous intraepithelial lesions (HSIL) was 3.8%. The most common genotypes were 16(23%), 53(20.3%), and 52(16.2%). The factor associated with HR-HPV infection was age <30 years (odds ratio[OR],2.5; 95%confidence interval[CI],1.1-5.6). The factors associated with the presence of HSIL or low-grade squamous intraepithelial lesions (LSIL) were CD4T-lymphocyte count <200cells/mm3 versus >500cells/mm3 (OR,8.4; 95%CI,3.7-19.2), HIV-1 viral load >10,000copies/mL versus <400copies/mL (OR,2.1; 95%CI,1.0-4.4), and use of oral contraceptives (OR,2.0; 95%CI,1.0-3.9). Sixty percent of HIV-1-infected women had had one Pap smear within the last 2 years. Conclusions The high prevalence of HPV infection and cervical lesions in the HIV-1-infected population in Catalonia, as well as the low coverage and frequency of screening in this group, means that better preventive efforts are necessary and should include vaccination against HPV, better accessibility to screening programs, training of health care professionals, and specific health education for HIV-1-infected women.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><language>eng</language><publisher>Public Library of Science (PLoS)</publisher><subject>Catalonia ; Catalunya ; Cervix cancer ; Càncer de coll uterí ; Dones ; HIV (Viruses) ; Medicina preventiva ; Papillomaviruses ; Papil·lomavirus ; Preventive medicine ; VIH (Virus) ; Women</subject><ispartof>PloS one, 2012-10</ispartof><rights>cc-by (c) Stuardo, Valeria et al., 2012 info:eu-repo/semantics/openAccess <a href="http://creativecommons.org/licenses/by/3.0/es">http://creativecommons.org/licenses/by/3.0/es</a></rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,26951</link.rule.ids></links><search><creatorcontrib>Stuardo, Valeria</creatorcontrib><creatorcontrib>Agustí, Cristina</creatorcontrib><creatorcontrib>Godínez, José M</creatorcontrib><creatorcontrib>Montoliu, Alexandra</creatorcontrib><creatorcontrib>Torné Bladé, Aureli</creatorcontrib><creatorcontrib>Tarrats, Antoni</creatorcontrib><creatorcontrib>Alcalde, Carme</creatorcontrib><creatorcontrib>Martín, Dolores</creatorcontrib><creatorcontrib>Fernández-Montoli, Eulalia</creatorcontrib><creatorcontrib>Vanrell, Cristina</creatorcontrib><creatorcontrib>Solé, Josefa</creatorcontrib><creatorcontrib>Canet, Yolanda</creatorcontrib><creatorcontrib>Marqueta, José M</creatorcontrib><creatorcontrib>Mohamed, Jadiyettu</creatorcontrib><creatorcontrib>Cuenca, Isabel</creatorcontrib><creatorcontrib>Lonca, Montserrat</creatorcontrib><creatorcontrib>Sirera, Guillem</creatorcontrib><creatorcontrib>Ferrer, Elena</creatorcontrib><creatorcontrib>Domingo, Pere</creatorcontrib><creatorcontrib>Lloveras Rubio, Belén</creatorcontrib><creatorcontrib>Miró Meda, José M</creatorcontrib><creatorcontrib>Sanjosé Llongueras, Silvia de</creatorcontrib><creatorcontrib>Casabona, Jordi</creatorcontrib><title>Human Papillomavirus Infection in HIV-1 Infected Women in Catalonia (Spain): Implications for Prevention of Cervical Cancer</title><title>PloS one</title><description>Background High-risk human Papillomavirus infection is a necessary factor for cervical squamous intraepithelial lesions and invasive cervical cancer. In HIV-1-infected women, HPV infection is more prevalent and a higher risk of cervical cancer has been identified. We aimed to calculate the prevalence of infection by HR-HPV, determine the factors associated with this infection and abnormal cytology findings and to describe the history of cervical cancer screening in HIV-1-infected women. Methods We enrolled 479 HIV-1-infected women from the PISCIS cohort. Each patient underwent a gynecological check-up, PAP smear, HPV AND Hybrid capture, HPV genotyping, and colposcopy and biopsy, if necessary. We applied questionnaires to obtain information on sociodemographic, behavioral, clinical, and cervical screening variables. We present a cross-sectional analysis. Results Median age was 42 years. The prevalence of HR-HPV infection was 33.2% and that of high-grade squamous intraepithelial lesions (HSIL) was 3.8%. The most common genotypes were 16(23%), 53(20.3%), and 52(16.2%). The factor associated with HR-HPV infection was age <30 years (odds ratio[OR],2.5; 95%confidence interval[CI],1.1-5.6). The factors associated with the presence of HSIL or low-grade squamous intraepithelial lesions (LSIL) were CD4T-lymphocyte count <200cells/mm3 versus >500cells/mm3 (OR,8.4; 95%CI,3.7-19.2), HIV-1 viral load >10,000copies/mL versus <400copies/mL (OR,2.1; 95%CI,1.0-4.4), and use of oral contraceptives (OR,2.0; 95%CI,1.0-3.9). Sixty percent of HIV-1-infected women had had one Pap smear within the last 2 years. Conclusions The high prevalence of HPV infection and cervical lesions in the HIV-1-infected population in Catalonia, as well as the low coverage and frequency of screening in this group, means that better preventive efforts are necessary and should include vaccination against HPV, better accessibility to screening programs, training of health care professionals, and specific health education for HIV-1-infected women.</description><subject>Catalonia</subject><subject>Catalunya</subject><subject>Cervix cancer</subject><subject>Càncer de coll uterí</subject><subject>Dones</subject><subject>HIV (Viruses)</subject><subject>Medicina preventiva</subject><subject>Papillomaviruses</subject><subject>Papil·lomavirus</subject><subject>Preventive medicine</subject><subject>VIH (Virus)</subject><subject>Women</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>XX2</sourceid><recordid>eNqdjEsLwjAQhIMoWB__YY96KLQJ1se1KO1NUPRYlriFSJqUpO3FP28VQc8elt2dmW8GLIi3gocJj8Tw5x6ziff3KFqJTZIE7JG1FRo4Yq20thV2yrUeclOSbJQ1oAxk-SWMPxLd4GoreuspNqitUQiLU43KLHeQV7VWEl-kh9I6ODrqyLybbAkpua63dY8aSW7GRiVqT_PPnrL4sD-nWSh9KwtHfaTvKiyq7_MaHq15IQRfb7n4h3kCVCtZQg</recordid><startdate>20121030</startdate><enddate>20121030</enddate><creator>Stuardo, Valeria</creator><creator>Agustí, Cristina</creator><creator>Godínez, José M</creator><creator>Montoliu, Alexandra</creator><creator>Torné Bladé, Aureli</creator><creator>Tarrats, Antoni</creator><creator>Alcalde, Carme</creator><creator>Martín, Dolores</creator><creator>Fernández-Montoli, Eulalia</creator><creator>Vanrell, Cristina</creator><creator>Solé, Josefa</creator><creator>Canet, Yolanda</creator><creator>Marqueta, José M</creator><creator>Mohamed, Jadiyettu</creator><creator>Cuenca, Isabel</creator><creator>Lonca, Montserrat</creator><creator>Sirera, Guillem</creator><creator>Ferrer, Elena</creator><creator>Domingo, Pere</creator><creator>Lloveras Rubio, Belén</creator><creator>Miró Meda, José M</creator><creator>Sanjosé Llongueras, Silvia de</creator><creator>Casabona, Jordi</creator><general>Public Library of Science (PLoS)</general><scope>XX2</scope></search><sort><creationdate>20121030</creationdate><title>Human Papillomavirus Infection in HIV-1 Infected Women in Catalonia (Spain): Implications for Prevention of Cervical Cancer</title><author>Stuardo, Valeria ; Agustí, Cristina ; Godínez, José M ; Montoliu, Alexandra ; Torné Bladé, Aureli ; Tarrats, Antoni ; Alcalde, Carme ; Martín, Dolores ; Fernández-Montoli, Eulalia ; Vanrell, Cristina ; Solé, Josefa ; Canet, Yolanda ; Marqueta, José M ; Mohamed, Jadiyettu ; Cuenca, Isabel ; Lonca, Montserrat ; Sirera, Guillem ; Ferrer, Elena ; Domingo, Pere ; Lloveras Rubio, Belén ; Miró Meda, José M ; Sanjosé Llongueras, Silvia de ; Casabona, Jordi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-csuc_recercat_oai_recercat_cat_2072_3327923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Catalonia</topic><topic>Catalunya</topic><topic>Cervix cancer</topic><topic>Càncer de coll uterí</topic><topic>Dones</topic><topic>HIV (Viruses)</topic><topic>Medicina preventiva</topic><topic>Papillomaviruses</topic><topic>Papil·lomavirus</topic><topic>Preventive medicine</topic><topic>VIH (Virus)</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stuardo, Valeria</creatorcontrib><creatorcontrib>Agustí, Cristina</creatorcontrib><creatorcontrib>Godínez, José M</creatorcontrib><creatorcontrib>Montoliu, Alexandra</creatorcontrib><creatorcontrib>Torné Bladé, Aureli</creatorcontrib><creatorcontrib>Tarrats, Antoni</creatorcontrib><creatorcontrib>Alcalde, Carme</creatorcontrib><creatorcontrib>Martín, Dolores</creatorcontrib><creatorcontrib>Fernández-Montoli, Eulalia</creatorcontrib><creatorcontrib>Vanrell, Cristina</creatorcontrib><creatorcontrib>Solé, Josefa</creatorcontrib><creatorcontrib>Canet, Yolanda</creatorcontrib><creatorcontrib>Marqueta, José M</creatorcontrib><creatorcontrib>Mohamed, Jadiyettu</creatorcontrib><creatorcontrib>Cuenca, Isabel</creatorcontrib><creatorcontrib>Lonca, Montserrat</creatorcontrib><creatorcontrib>Sirera, Guillem</creatorcontrib><creatorcontrib>Ferrer, Elena</creatorcontrib><creatorcontrib>Domingo, Pere</creatorcontrib><creatorcontrib>Lloveras Rubio, Belén</creatorcontrib><creatorcontrib>Miró Meda, José M</creatorcontrib><creatorcontrib>Sanjosé Llongueras, Silvia de</creatorcontrib><creatorcontrib>Casabona, Jordi</creatorcontrib><collection>Recercat</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stuardo, Valeria</au><au>Agustí, Cristina</au><au>Godínez, José M</au><au>Montoliu, Alexandra</au><au>Torné Bladé, Aureli</au><au>Tarrats, Antoni</au><au>Alcalde, Carme</au><au>Martín, Dolores</au><au>Fernández-Montoli, Eulalia</au><au>Vanrell, Cristina</au><au>Solé, Josefa</au><au>Canet, Yolanda</au><au>Marqueta, José M</au><au>Mohamed, Jadiyettu</au><au>Cuenca, Isabel</au><au>Lonca, Montserrat</au><au>Sirera, Guillem</au><au>Ferrer, Elena</au><au>Domingo, Pere</au><au>Lloveras Rubio, Belén</au><au>Miró Meda, José M</au><au>Sanjosé Llongueras, Silvia de</au><au>Casabona, Jordi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human Papillomavirus Infection in HIV-1 Infected Women in Catalonia (Spain): Implications for Prevention of Cervical Cancer</atitle><jtitle>PloS one</jtitle><date>2012-10-30</date><risdate>2012</risdate><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Background High-risk human Papillomavirus infection is a necessary factor for cervical squamous intraepithelial lesions and invasive cervical cancer. In HIV-1-infected women, HPV infection is more prevalent and a higher risk of cervical cancer has been identified. We aimed to calculate the prevalence of infection by HR-HPV, determine the factors associated with this infection and abnormal cytology findings and to describe the history of cervical cancer screening in HIV-1-infected women. Methods We enrolled 479 HIV-1-infected women from the PISCIS cohort. Each patient underwent a gynecological check-up, PAP smear, HPV AND Hybrid capture, HPV genotyping, and colposcopy and biopsy, if necessary. We applied questionnaires to obtain information on sociodemographic, behavioral, clinical, and cervical screening variables. We present a cross-sectional analysis. Results Median age was 42 years. The prevalence of HR-HPV infection was 33.2% and that of high-grade squamous intraepithelial lesions (HSIL) was 3.8%. The most common genotypes were 16(23%), 53(20.3%), and 52(16.2%). The factor associated with HR-HPV infection was age <30 years (odds ratio[OR],2.5; 95%confidence interval[CI],1.1-5.6). The factors associated with the presence of HSIL or low-grade squamous intraepithelial lesions (LSIL) were CD4T-lymphocyte count <200cells/mm3 versus >500cells/mm3 (OR,8.4; 95%CI,3.7-19.2), HIV-1 viral load >10,000copies/mL versus <400copies/mL (OR,2.1; 95%CI,1.0-4.4), and use of oral contraceptives (OR,2.0; 95%CI,1.0-3.9). Sixty percent of HIV-1-infected women had had one Pap smear within the last 2 years. Conclusions The high prevalence of HPV infection and cervical lesions in the HIV-1-infected population in Catalonia, as well as the low coverage and frequency of screening in this group, means that better preventive efforts are necessary and should include vaccination against HPV, better accessibility to screening programs, training of health care professionals, and specific health education for HIV-1-infected women.</abstract><pub>Public Library of Science (PLoS)</pub><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-10 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_csuc_recercat_oai_recercat_cat_2072_332792 |
| source | DOAJ Directory of Open Access Journals; Recercat; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Catalonia Catalunya Cervix cancer Càncer de coll uterí Dones HIV (Viruses) Medicina preventiva Papillomaviruses Papil·lomavirus Preventive medicine VIH (Virus) Women |
| title | Human Papillomavirus Infection in HIV-1 Infected Women in Catalonia (Spain): Implications for Prevention of Cervical Cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T19%3A14%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-csuc&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Human%20Papillomavirus%20Infection%20in%20HIV-1%20Infected%20Women%20in%20Catalonia%20(Spain):%20Implications%20for%20Prevention%20of%20Cervical%20Cancer&rft.jtitle=PloS%20one&rft.au=Stuardo,%20Valeria&rft.date=2012-10-30&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/&rft_dat=%3Ccsuc%3Eoai_recercat_cat_2072_332792%3C/csuc%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |