The effects of death and post-mortem cold ischemia on human tissue transcriptomes

Post-mortem tissues samples are a key resource for investigating patterns of gene expression. However, the processes triggered by death and the post-mortem interval (PMI) can significantly alter physiologically normal RNA levels. We investigate the impact of PMI on gene expression using data from mu...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature communications 2018
Hauptverfasser: Ferreira, Pedro G, Muñoz-Aguirre, Manuel, Reverter Comes, Ferran, Godinho, Caio P. Sá, Sousa, Abel, Amadoz, Alicia, Sodaei, Reza, Hidalgo, Marta R, Pervouchine, Dmitri D, Carbonell-Caballero, Jose, Nurtdinov, Ramil, Breschi, Alessandra, 1988, Amador, Raziel, Oliveira, Patrícia, Çubut, Cankut, Curado, Joao, Aguet, François, Oliveira, Carla, Dopazo, Joaquín, Sammeth, Michael, Ardlie, Kristin G, Guigó Serra, Roderic
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title Nature communications
container_volume
creator Ferreira, Pedro G
Muñoz-Aguirre, Manuel
Reverter Comes, Ferran
Godinho, Caio P. Sá
Sousa, Abel
Amadoz, Alicia
Sodaei, Reza
Hidalgo, Marta R
Pervouchine, Dmitri D
Carbonell-Caballero, Jose
Nurtdinov, Ramil
Breschi, Alessandra, 1988
Amador, Raziel
Oliveira, Patrícia
Çubut, Cankut
Curado, Joao
Aguet, François
Oliveira, Carla
Dopazo, Joaquín
Sammeth, Michael
Ardlie, Kristin G
Guigó Serra, Roderic
description Post-mortem tissues samples are a key resource for investigating patterns of gene expression. However, the processes triggered by death and the post-mortem interval (PMI) can significantly alter physiologically normal RNA levels. We investigate the impact of PMI on gene expression using data from multiple tissues of post-mortem donors obtained from the GTEx project. We find that many genes change expression over relatively short PMIs in a tissue-specific manner, but this potentially confounding effect in a biological analysis can be minimized by taking into account appropriate covariates. By comparing ante- and post-mortem blood samples, we identify the cascade of transcriptional events triggered by death of the organism. These events do not appear to simply reflect stochastic variation resulting from mRNA degradation, but active and ongoing regulation of transcription. Finally, we develop a model to predict the time since death from the analysis of the transcriptome of a few readily accessible tissues. This work was supported by the following grants and contracts: 1) From the US NIH: Contract HHSN261200800001E (Leidos Prime contract with NCI); Contracts 10XS170 (NDRI), 10XS171 (Roswell Park Cancer Institute), 10 × 172 (Science Care Inc.), and 12ST1039 (IDOX); Contract 10ST1035 (Van Andel Institute); Contract HHSN268201000029C (Broad Institute); R01 DA006227-17 (U Miami Brain Bank) 2) Ipatimup and i3s are partially funded by the Portuguese Foundation for Science and Technology (FCT); FEDER funds through the COMPETE 2020—Operacional Programme for Competitiveness and Internationalization (POCI), Portugal 2020, and by Portuguese funds through FCT/MCTES in the framework POCI-01-0145-FEDER-007274; 3) NORTE-01-0145-FEDER-000029, supported by NORTE 2020, under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF); 4) FCT Fellowships SFRH/BPD/89764/2012 to PO, PD/BD/128007/2016 to AS; Salary support to PGF by POPH—QREN Type 4.2, European Social Fund and MCTES, program Investigador FCT, IF/01127/2014. 5) BIO2014-57291-R from the Spanish Ministry of Economy and Competitiveness and “Plataforma de Recursos Biomoleculares y Bioinformáticos” PT13/0001/0007 from the ISCIII, and EU H2020-INFRADEV-1-2015-1 ELIXIR-EXCELERATE (ref. 6,676559) Spanish Ministry of Economy and Competitiveness, ‘Centro de Excelencia Severo Ochoa 2013-2017’ and CERCA Programme/Generalitat de Catalunya, 7) Ministerio de Educación, Cultura y Deporte, under th
doi_str_mv 10.1038/s41467-017-02772-x
format Article
fullrecord <record><control><sourceid>csuc</sourceid><recordid>TN_cdi_csuc_recercat_oai_recercat_cat_2072_314945</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>oai_recercat_cat_2072_314945</sourcerecordid><originalsourceid>FETCH-csuc_recercat_oai_recercat_cat_2072_3149453</originalsourceid><addsrcrecordid>eNqdi8GKAjEQRMOisKL-gKf-gWg6iUbPi7JXwfsQMj1MxEwknYH9_HVhQc8WPOrVoYRYoVqjMvsNW7Q7JxU-0M5p-fMhZlpZlOi0mbz4p1gyX9Uj5oB7a2fifOkJqOsoVIbcQUu-9uCHFu6Zq0y5VEoQ8q2FyKGnFD3kAfox-QFqZB4JavEDhxLvNSfihZh2_sa0_O-5wNPx8vUtA4-hKRSoBF-b7ONz_KGV041Be7Bb887nF-pJUZ4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The effects of death and post-mortem cold ischemia on human tissue transcriptomes</title><source>DOAJ Directory of Open Access Journals</source><source>Springer Nature OA Free Journals</source><source>Nature Free</source><source>Recercat</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Ferreira, Pedro G ; Muñoz-Aguirre, Manuel ; Reverter Comes, Ferran ; Godinho, Caio P. Sá ; Sousa, Abel ; Amadoz, Alicia ; Sodaei, Reza ; Hidalgo, Marta R ; Pervouchine, Dmitri D ; Carbonell-Caballero, Jose ; Nurtdinov, Ramil ; Breschi, Alessandra, 1988 ; Amador, Raziel ; Oliveira, Patrícia ; Çubut, Cankut ; Curado, Joao ; Aguet, François ; Oliveira, Carla ; Dopazo, Joaquín ; Sammeth, Michael ; Ardlie, Kristin G ; Guigó Serra, Roderic</creator><creatorcontrib>Ferreira, Pedro G ; Muñoz-Aguirre, Manuel ; Reverter Comes, Ferran ; Godinho, Caio P. Sá ; Sousa, Abel ; Amadoz, Alicia ; Sodaei, Reza ; Hidalgo, Marta R ; Pervouchine, Dmitri D ; Carbonell-Caballero, Jose ; Nurtdinov, Ramil ; Breschi, Alessandra, 1988 ; Amador, Raziel ; Oliveira, Patrícia ; Çubut, Cankut ; Curado, Joao ; Aguet, François ; Oliveira, Carla ; Dopazo, Joaquín ; Sammeth, Michael ; Ardlie, Kristin G ; Guigó Serra, Roderic</creatorcontrib><description>Post-mortem tissues samples are a key resource for investigating patterns of gene expression. However, the processes triggered by death and the post-mortem interval (PMI) can significantly alter physiologically normal RNA levels. We investigate the impact of PMI on gene expression using data from multiple tissues of post-mortem donors obtained from the GTEx project. We find that many genes change expression over relatively short PMIs in a tissue-specific manner, but this potentially confounding effect in a biological analysis can be minimized by taking into account appropriate covariates. By comparing ante- and post-mortem blood samples, we identify the cascade of transcriptional events triggered by death of the organism. These events do not appear to simply reflect stochastic variation resulting from mRNA degradation, but active and ongoing regulation of transcription. Finally, we develop a model to predict the time since death from the analysis of the transcriptome of a few readily accessible tissues. This work was supported by the following grants and contracts: 1) From the US NIH: Contract HHSN261200800001E (Leidos Prime contract with NCI); Contracts 10XS170 (NDRI), 10XS171 (Roswell Park Cancer Institute), 10 × 172 (Science Care Inc.), and 12ST1039 (IDOX); Contract 10ST1035 (Van Andel Institute); Contract HHSN268201000029C (Broad Institute); R01 DA006227-17 (U Miami Brain Bank) 2) Ipatimup and i3s are partially funded by the Portuguese Foundation for Science and Technology (FCT); FEDER funds through the COMPETE 2020—Operacional Programme for Competitiveness and Internationalization (POCI), Portugal 2020, and by Portuguese funds through FCT/MCTES in the framework POCI-01-0145-FEDER-007274; 3) NORTE-01-0145-FEDER-000029, supported by NORTE 2020, under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF); 4) FCT Fellowships SFRH/BPD/89764/2012 to PO, PD/BD/128007/2016 to AS; Salary support to PGF by POPH—QREN Type 4.2, European Social Fund and MCTES, program Investigador FCT, IF/01127/2014. 5) BIO2014-57291-R from the Spanish Ministry of Economy and Competitiveness and “Plataforma de Recursos Biomoleculares y Bioinformáticos” PT13/0001/0007 from the ISCIII, and EU H2020-INFRADEV-1-2015-1 ELIXIR-EXCELERATE (ref. 6,676559) Spanish Ministry of Economy and Competitiveness, ‘Centro de Excelencia Severo Ochoa 2013-2017’ and CERCA Programme/Generalitat de Catalunya, 7) Ministerio de Educación, Cultura y Deporte, under the FPU programme (Formación de Profesorado Universitario) with pre-doctoral fellowship FPU15/03635 to MMA. 8) Award Number 1R01MH101814 and 3R01MH101814-03S1 from the National Human Genome Research Institute. European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013) / ERC grant agreement RNA-MAPS_294653, Ministerio de Economía, Industria y Competitividad, referencia MEIC BIO2015-70777-P y los Fondos Estructurales de la Unión Europea (FEDER) and ISCIII del Ministerio de Economía y Competitividad, referencia PT13/0001/0021 cofinaciada por el Fondo Europeo de Desarrollo Regional (FEDER). 9) MS received funding from CNPq (grant 310132/2015-0 and 427541/2016-6), and from FAPERJ (grant E_06/2015).</description><identifier>ISSN: 2041-1723</identifier><identifier>EISSN: 2041-1723</identifier><identifier>DOI: 10.1038/s41467-017-02772-x</identifier><language>eng</language><publisher>Nature Publishing Group</publisher><subject>Aprenentatge automàtic ; Expressió gènica ; Genòmica ; Mineria de dades</subject><ispartof>Nature communications, 2018</ispartof><rights>info:eu-repo/semantics/openAccess © Nature Publishing Group. http://dx.doi.org/10.1038/s41467-017-02772-x. &lt;a href="http://creativecommons.org/licenses/by/4.0/"&gt;http://creativecommons.org/licenses/by/4.0/&lt;/a&gt; &lt;a href="http://creativecommons.org/licenses/by/4.0/"&gt;http://creativecommons.org/licenses/by/4.0/&lt;/a&gt;</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,864,885,4024,26974,27923,27924,27925</link.rule.ids></links><search><creatorcontrib>Ferreira, Pedro G</creatorcontrib><creatorcontrib>Muñoz-Aguirre, Manuel</creatorcontrib><creatorcontrib>Reverter Comes, Ferran</creatorcontrib><creatorcontrib>Godinho, Caio P. Sá</creatorcontrib><creatorcontrib>Sousa, Abel</creatorcontrib><creatorcontrib>Amadoz, Alicia</creatorcontrib><creatorcontrib>Sodaei, Reza</creatorcontrib><creatorcontrib>Hidalgo, Marta R</creatorcontrib><creatorcontrib>Pervouchine, Dmitri D</creatorcontrib><creatorcontrib>Carbonell-Caballero, Jose</creatorcontrib><creatorcontrib>Nurtdinov, Ramil</creatorcontrib><creatorcontrib>Breschi, Alessandra, 1988</creatorcontrib><creatorcontrib>Amador, Raziel</creatorcontrib><creatorcontrib>Oliveira, Patrícia</creatorcontrib><creatorcontrib>Çubut, Cankut</creatorcontrib><creatorcontrib>Curado, Joao</creatorcontrib><creatorcontrib>Aguet, François</creatorcontrib><creatorcontrib>Oliveira, Carla</creatorcontrib><creatorcontrib>Dopazo, Joaquín</creatorcontrib><creatorcontrib>Sammeth, Michael</creatorcontrib><creatorcontrib>Ardlie, Kristin G</creatorcontrib><creatorcontrib>Guigó Serra, Roderic</creatorcontrib><title>The effects of death and post-mortem cold ischemia on human tissue transcriptomes</title><title>Nature communications</title><description>Post-mortem tissues samples are a key resource for investigating patterns of gene expression. However, the processes triggered by death and the post-mortem interval (PMI) can significantly alter physiologically normal RNA levels. We investigate the impact of PMI on gene expression using data from multiple tissues of post-mortem donors obtained from the GTEx project. We find that many genes change expression over relatively short PMIs in a tissue-specific manner, but this potentially confounding effect in a biological analysis can be minimized by taking into account appropriate covariates. By comparing ante- and post-mortem blood samples, we identify the cascade of transcriptional events triggered by death of the organism. These events do not appear to simply reflect stochastic variation resulting from mRNA degradation, but active and ongoing regulation of transcription. Finally, we develop a model to predict the time since death from the analysis of the transcriptome of a few readily accessible tissues. This work was supported by the following grants and contracts: 1) From the US NIH: Contract HHSN261200800001E (Leidos Prime contract with NCI); Contracts 10XS170 (NDRI), 10XS171 (Roswell Park Cancer Institute), 10 × 172 (Science Care Inc.), and 12ST1039 (IDOX); Contract 10ST1035 (Van Andel Institute); Contract HHSN268201000029C (Broad Institute); R01 DA006227-17 (U Miami Brain Bank) 2) Ipatimup and i3s are partially funded by the Portuguese Foundation for Science and Technology (FCT); FEDER funds through the COMPETE 2020—Operacional Programme for Competitiveness and Internationalization (POCI), Portugal 2020, and by Portuguese funds through FCT/MCTES in the framework POCI-01-0145-FEDER-007274; 3) NORTE-01-0145-FEDER-000029, supported by NORTE 2020, under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF); 4) FCT Fellowships SFRH/BPD/89764/2012 to PO, PD/BD/128007/2016 to AS; Salary support to PGF by POPH—QREN Type 4.2, European Social Fund and MCTES, program Investigador FCT, IF/01127/2014. 5) BIO2014-57291-R from the Spanish Ministry of Economy and Competitiveness and “Plataforma de Recursos Biomoleculares y Bioinformáticos” PT13/0001/0007 from the ISCIII, and EU H2020-INFRADEV-1-2015-1 ELIXIR-EXCELERATE (ref. 6,676559) Spanish Ministry of Economy and Competitiveness, ‘Centro de Excelencia Severo Ochoa 2013-2017’ and CERCA Programme/Generalitat de Catalunya, 7) Ministerio de Educación, Cultura y Deporte, under the FPU programme (Formación de Profesorado Universitario) with pre-doctoral fellowship FPU15/03635 to MMA. 8) Award Number 1R01MH101814 and 3R01MH101814-03S1 from the National Human Genome Research Institute. European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013) / ERC grant agreement RNA-MAPS_294653, Ministerio de Economía, Industria y Competitividad, referencia MEIC BIO2015-70777-P y los Fondos Estructurales de la Unión Europea (FEDER) and ISCIII del Ministerio de Economía y Competitividad, referencia PT13/0001/0021 cofinaciada por el Fondo Europeo de Desarrollo Regional (FEDER). 9) MS received funding from CNPq (grant 310132/2015-0 and 427541/2016-6), and from FAPERJ (grant E_06/2015).</description><subject>Aprenentatge automàtic</subject><subject>Expressió gènica</subject><subject>Genòmica</subject><subject>Mineria de dades</subject><issn>2041-1723</issn><issn>2041-1723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>XX2</sourceid><recordid>eNqdi8GKAjEQRMOisKL-gKf-gWg6iUbPi7JXwfsQMj1MxEwknYH9_HVhQc8WPOrVoYRYoVqjMvsNW7Q7JxU-0M5p-fMhZlpZlOi0mbz4p1gyX9Uj5oB7a2fifOkJqOsoVIbcQUu-9uCHFu6Zq0y5VEoQ8q2FyKGnFD3kAfox-QFqZB4JavEDhxLvNSfihZh2_sa0_O-5wNPx8vUtA4-hKRSoBF-b7ONz_KGV041Be7Bb887nF-pJUZ4</recordid><startdate>2018</startdate><enddate>2018</enddate><creator>Ferreira, Pedro G</creator><creator>Muñoz-Aguirre, Manuel</creator><creator>Reverter Comes, Ferran</creator><creator>Godinho, Caio P. Sá</creator><creator>Sousa, Abel</creator><creator>Amadoz, Alicia</creator><creator>Sodaei, Reza</creator><creator>Hidalgo, Marta R</creator><creator>Pervouchine, Dmitri D</creator><creator>Carbonell-Caballero, Jose</creator><creator>Nurtdinov, Ramil</creator><creator>Breschi, Alessandra, 1988</creator><creator>Amador, Raziel</creator><creator>Oliveira, Patrícia</creator><creator>Çubut, Cankut</creator><creator>Curado, Joao</creator><creator>Aguet, François</creator><creator>Oliveira, Carla</creator><creator>Dopazo, Joaquín</creator><creator>Sammeth, Michael</creator><creator>Ardlie, Kristin G</creator><creator>Guigó Serra, Roderic</creator><general>Nature Publishing Group</general><scope>XX2</scope></search><sort><creationdate>2018</creationdate><title>The effects of death and post-mortem cold ischemia on human tissue transcriptomes</title><author>Ferreira, Pedro G ; Muñoz-Aguirre, Manuel ; Reverter Comes, Ferran ; Godinho, Caio P. Sá ; Sousa, Abel ; Amadoz, Alicia ; Sodaei, Reza ; Hidalgo, Marta R ; Pervouchine, Dmitri D ; Carbonell-Caballero, Jose ; Nurtdinov, Ramil ; Breschi, Alessandra, 1988 ; Amador, Raziel ; Oliveira, Patrícia ; Çubut, Cankut ; Curado, Joao ; Aguet, François ; Oliveira, Carla ; Dopazo, Joaquín ; Sammeth, Michael ; Ardlie, Kristin G ; Guigó Serra, Roderic</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-csuc_recercat_oai_recercat_cat_2072_3149453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aprenentatge automàtic</topic><topic>Expressió gènica</topic><topic>Genòmica</topic><topic>Mineria de dades</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferreira, Pedro G</creatorcontrib><creatorcontrib>Muñoz-Aguirre, Manuel</creatorcontrib><creatorcontrib>Reverter Comes, Ferran</creatorcontrib><creatorcontrib>Godinho, Caio P. Sá</creatorcontrib><creatorcontrib>Sousa, Abel</creatorcontrib><creatorcontrib>Amadoz, Alicia</creatorcontrib><creatorcontrib>Sodaei, Reza</creatorcontrib><creatorcontrib>Hidalgo, Marta R</creatorcontrib><creatorcontrib>Pervouchine, Dmitri D</creatorcontrib><creatorcontrib>Carbonell-Caballero, Jose</creatorcontrib><creatorcontrib>Nurtdinov, Ramil</creatorcontrib><creatorcontrib>Breschi, Alessandra, 1988</creatorcontrib><creatorcontrib>Amador, Raziel</creatorcontrib><creatorcontrib>Oliveira, Patrícia</creatorcontrib><creatorcontrib>Çubut, Cankut</creatorcontrib><creatorcontrib>Curado, Joao</creatorcontrib><creatorcontrib>Aguet, François</creatorcontrib><creatorcontrib>Oliveira, Carla</creatorcontrib><creatorcontrib>Dopazo, Joaquín</creatorcontrib><creatorcontrib>Sammeth, Michael</creatorcontrib><creatorcontrib>Ardlie, Kristin G</creatorcontrib><creatorcontrib>Guigó Serra, Roderic</creatorcontrib><collection>Recercat</collection><jtitle>Nature communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ferreira, Pedro G</au><au>Muñoz-Aguirre, Manuel</au><au>Reverter Comes, Ferran</au><au>Godinho, Caio P. Sá</au><au>Sousa, Abel</au><au>Amadoz, Alicia</au><au>Sodaei, Reza</au><au>Hidalgo, Marta R</au><au>Pervouchine, Dmitri D</au><au>Carbonell-Caballero, Jose</au><au>Nurtdinov, Ramil</au><au>Breschi, Alessandra, 1988</au><au>Amador, Raziel</au><au>Oliveira, Patrícia</au><au>Çubut, Cankut</au><au>Curado, Joao</au><au>Aguet, François</au><au>Oliveira, Carla</au><au>Dopazo, Joaquín</au><au>Sammeth, Michael</au><au>Ardlie, Kristin G</au><au>Guigó Serra, Roderic</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of death and post-mortem cold ischemia on human tissue transcriptomes</atitle><jtitle>Nature communications</jtitle><date>2018</date><risdate>2018</risdate><issn>2041-1723</issn><eissn>2041-1723</eissn><abstract>Post-mortem tissues samples are a key resource for investigating patterns of gene expression. However, the processes triggered by death and the post-mortem interval (PMI) can significantly alter physiologically normal RNA levels. We investigate the impact of PMI on gene expression using data from multiple tissues of post-mortem donors obtained from the GTEx project. We find that many genes change expression over relatively short PMIs in a tissue-specific manner, but this potentially confounding effect in a biological analysis can be minimized by taking into account appropriate covariates. By comparing ante- and post-mortem blood samples, we identify the cascade of transcriptional events triggered by death of the organism. These events do not appear to simply reflect stochastic variation resulting from mRNA degradation, but active and ongoing regulation of transcription. Finally, we develop a model to predict the time since death from the analysis of the transcriptome of a few readily accessible tissues. This work was supported by the following grants and contracts: 1) From the US NIH: Contract HHSN261200800001E (Leidos Prime contract with NCI); Contracts 10XS170 (NDRI), 10XS171 (Roswell Park Cancer Institute), 10 × 172 (Science Care Inc.), and 12ST1039 (IDOX); Contract 10ST1035 (Van Andel Institute); Contract HHSN268201000029C (Broad Institute); R01 DA006227-17 (U Miami Brain Bank) 2) Ipatimup and i3s are partially funded by the Portuguese Foundation for Science and Technology (FCT); FEDER funds through the COMPETE 2020—Operacional Programme for Competitiveness and Internationalization (POCI), Portugal 2020, and by Portuguese funds through FCT/MCTES in the framework POCI-01-0145-FEDER-007274; 3) NORTE-01-0145-FEDER-000029, supported by NORTE 2020, under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF); 4) FCT Fellowships SFRH/BPD/89764/2012 to PO, PD/BD/128007/2016 to AS; Salary support to PGF by POPH—QREN Type 4.2, European Social Fund and MCTES, program Investigador FCT, IF/01127/2014. 5) BIO2014-57291-R from the Spanish Ministry of Economy and Competitiveness and “Plataforma de Recursos Biomoleculares y Bioinformáticos” PT13/0001/0007 from the ISCIII, and EU H2020-INFRADEV-1-2015-1 ELIXIR-EXCELERATE (ref. 6,676559) Spanish Ministry of Economy and Competitiveness, ‘Centro de Excelencia Severo Ochoa 2013-2017’ and CERCA Programme/Generalitat de Catalunya, 7) Ministerio de Educación, Cultura y Deporte, under the FPU programme (Formación de Profesorado Universitario) with pre-doctoral fellowship FPU15/03635 to MMA. 8) Award Number 1R01MH101814 and 3R01MH101814-03S1 from the National Human Genome Research Institute. European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013) / ERC grant agreement RNA-MAPS_294653, Ministerio de Economía, Industria y Competitividad, referencia MEIC BIO2015-70777-P y los Fondos Estructurales de la Unión Europea (FEDER) and ISCIII del Ministerio de Economía y Competitividad, referencia PT13/0001/0021 cofinaciada por el Fondo Europeo de Desarrollo Regional (FEDER). 9) MS received funding from CNPq (grant 310132/2015-0 and 427541/2016-6), and from FAPERJ (grant E_06/2015).</abstract><pub>Nature Publishing Group</pub><doi>10.1038/s41467-017-02772-x</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2041-1723
ispartof Nature communications, 2018
issn 2041-1723
2041-1723
language eng
recordid cdi_csuc_recercat_oai_recercat_cat_2072_314945
source DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; Recercat; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection
subjects Aprenentatge automàtic
Expressió gènica
Genòmica
Mineria de dades
title The effects of death and post-mortem cold ischemia on human tissue transcriptomes
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T19%3A16%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-csuc&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20effects%20of%20death%20and%20post-mortem%20cold%20ischemia%20on%20human%20tissue%20transcriptomes&rft.jtitle=Nature%20communications&rft.au=Ferreira,%20Pedro%20G&rft.date=2018&rft.issn=2041-1723&rft.eissn=2041-1723&rft_id=info:doi/10.1038/s41467-017-02772-x&rft_dat=%3Ccsuc%3Eoai_recercat_cat_2072_314945%3C/csuc%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true