Body Composition After Endogenous (Cushing's Syndrome) and Exogenous (Rheumatoid Arthritis) Exposure to Glucocorticoids
Abstract Exposure to chronic glucocorticoid (GC) excess determines changes in body composition. The aim of the study was to compare body composition in women exposed to endogenous hypercortisolism (Cushing's syndrome, CS), exogenous glucocorticoid treatment (rheumatoid arthritis, RA) and contro...
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| Veröffentlicht in: | Hormone and metabolic research 2010-07, Vol.42 (8), p.613-618 |
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| creator | Resmini, E. Farkas, C. Murillo, B. Barahona, M. J. Santos, A. Martínez-Momblán, M. A. Roig, O. Ybarra, J. Geli, C. Webb, S. M. |
| description | Abstract
Exposure to chronic glucocorticoid (GC) excess determines changes in body composition. The aim of the study was to compare body composition in women exposed to endogenous hypercortisolism (Cushing's syndrome, CS), exogenous glucocorticoid treatment (rheumatoid arthritis, RA) and controls. Fifty-one CS women, 26 RA women treated with low-dose prednisone (5 mg/day or 10 mg/2 days), and 78 female controls were included. Fourteen CS patients were hypercortisolemic, 37 in remission (10 required hydrocortisone substitution after surgery). Body composition parameters were measured by dual-energy X-ray absorptiometry scanning (DEXA). RA patients had a greater waist-hip ratio (WHR) (p |
| doi_str_mv | 10.1055/s-0030-1255032 |
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Exposure to chronic glucocorticoid (GC) excess determines changes in body composition. The aim of the study was to compare body composition in women exposed to endogenous hypercortisolism (Cushing's syndrome, CS), exogenous glucocorticoid treatment (rheumatoid arthritis, RA) and controls. Fifty-one CS women, 26 RA women treated with low-dose prednisone (5 mg/day or 10 mg/2 days), and 78 female controls were included. Fourteen CS patients were hypercortisolemic, 37 in remission (10 required hydrocortisone substitution after surgery). Body composition parameters were measured by dual-energy X-ray absorptiometry scanning (DEXA). RA patients had a greater waist-hip ratio (WHR) (p<0.01), less lean body mass (LBM) (p<0.01), and lumbar bone mineral density (BMD) (p<0.01) than controls. CS patients, globally and those with cured disease, had more total fat (both percentage and kg) and trunk fat percentage, and less whole body-BMD than RA patients (p<0.05, p<0.01, p<0.05, respectively). Active CS patients had less whole body-BMD and more LBM than RA patients (p<0.05, p=0.01, respectively). Cured CS patients not taking hydrocortisone had more total fat [both percentage (p<0.05) and kg (p<0.05)], trunk fat percentage (p<0.05), lumbar BMD (p<0.01) than RA patients. Cured CS patients requiring hydrocortisone only differed from RA patients by smaller WHR (p<0.01). All the differences in BMD disappeared when the data were reanalyzed including only the estrogen-deficient groups. Hypercortisoliof CS determines an irreversible increase in body fat, greater than in RA. Endogenous and exogenous exposure to GC negatively affects body composition by increasing the WHR. There appears to be no additional effect on BMD in estrogen-deficient women.]]></description><identifier>ISSN: 0018-5043</identifier><identifier>EISSN: 1439-4286</identifier><identifier>DOI: 10.1055/s-0030-1255032</identifier><identifier>PMID: 20514604</identifier><language>eng</language><publisher>Germany: Georg Thieme Verlag</publisher><subject>Arthritis, Rheumatoid - drug therapy ; Arthritis, Rheumatoid - physiopathology ; Artritis reumatoide ; Body composition ; Body Composition - physiology ; Case-Control Studies ; Composició corporal ; Cushing Syndrome - physiopathology ; Cushing's syndrome ; Estrogens - metabolism ; Female ; Glucocorticoides ; Glucocorticoids ; Glucocorticoids - therapeutic use ; Growth Hormone - deficiency ; Humans ; Humans, Clinical ; Middle Aged ; Rheumatoid arthritis ; Síndrome de Cushing</subject><ispartof>Hormone and metabolic research, 2010-07, Vol.42 (8), p.613-618</ispartof><rights>Georg Thieme Verlag KG Stuttgart · New York</rights><rights>(c) Georg Thieme Verlag KG Stuttgart . New York.</rights><rights>(c) Georg Thieme Verlag, 2010 info:eu-repo/semantics/openAccess</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-5fcf009cfa806af5d9065a72f3d34f8c3d3f4d7096ecadc1e1eacab00581086b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,780,885,26973</link.rule.ids><linktorsrc>$$Uhttps://recercat.cat/handle/2072/304252$$EView_record_in_Consorci_de_Serveis_Universitaris_de_Catalunya_(CSUC)$$FView_record_in_$$GConsorci_de_Serveis_Universitaris_de_Catalunya_(CSUC)$$Hfree_for_read</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20514604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Resmini, E.</creatorcontrib><creatorcontrib>Farkas, C.</creatorcontrib><creatorcontrib>Murillo, B.</creatorcontrib><creatorcontrib>Barahona, M. J.</creatorcontrib><creatorcontrib>Santos, A.</creatorcontrib><creatorcontrib>Martínez-Momblán, M. A.</creatorcontrib><creatorcontrib>Roig, O.</creatorcontrib><creatorcontrib>Ybarra, J.</creatorcontrib><creatorcontrib>Geli, C.</creatorcontrib><creatorcontrib>Webb, S. M.</creatorcontrib><title>Body Composition After Endogenous (Cushing's Syndrome) and Exogenous (Rheumatoid Arthritis) Exposure to Glucocorticoids</title><title>Hormone and metabolic research</title><addtitle>Horm Metab Res</addtitle><description><![CDATA[Abstract
Exposure to chronic glucocorticoid (GC) excess determines changes in body composition. The aim of the study was to compare body composition in women exposed to endogenous hypercortisolism (Cushing's syndrome, CS), exogenous glucocorticoid treatment (rheumatoid arthritis, RA) and controls. Fifty-one CS women, 26 RA women treated with low-dose prednisone (5 mg/day or 10 mg/2 days), and 78 female controls were included. Fourteen CS patients were hypercortisolemic, 37 in remission (10 required hydrocortisone substitution after surgery). Body composition parameters were measured by dual-energy X-ray absorptiometry scanning (DEXA). RA patients had a greater waist-hip ratio (WHR) (p<0.01), less lean body mass (LBM) (p<0.01), and lumbar bone mineral density (BMD) (p<0.01) than controls. CS patients, globally and those with cured disease, had more total fat (both percentage and kg) and trunk fat percentage, and less whole body-BMD than RA patients (p<0.05, p<0.01, p<0.05, respectively). Active CS patients had less whole body-BMD and more LBM than RA patients (p<0.05, p=0.01, respectively). Cured CS patients not taking hydrocortisone had more total fat [both percentage (p<0.05) and kg (p<0.05)], trunk fat percentage (p<0.05), lumbar BMD (p<0.01) than RA patients. Cured CS patients requiring hydrocortisone only differed from RA patients by smaller WHR (p<0.01). All the differences in BMD disappeared when the data were reanalyzed including only the estrogen-deficient groups. Hypercortisoliof CS determines an irreversible increase in body fat, greater than in RA. Endogenous and exogenous exposure to GC negatively affects body composition by increasing the WHR. There appears to be no additional effect on BMD in estrogen-deficient women.]]></description><subject>Arthritis, Rheumatoid - drug therapy</subject><subject>Arthritis, Rheumatoid - physiopathology</subject><subject>Artritis reumatoide</subject><subject>Body composition</subject><subject>Body Composition - physiology</subject><subject>Case-Control Studies</subject><subject>Composició corporal</subject><subject>Cushing Syndrome - physiopathology</subject><subject>Cushing's syndrome</subject><subject>Estrogens - metabolism</subject><subject>Female</subject><subject>Glucocorticoides</subject><subject>Glucocorticoids</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Growth Hormone - deficiency</subject><subject>Humans</subject><subject>Humans, Clinical</subject><subject>Middle Aged</subject><subject>Rheumatoid arthritis</subject><subject>Síndrome de Cushing</subject><issn>0018-5043</issn><issn>1439-4286</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>XX2</sourceid><recordid>eNp1kUtvUzEQRi0EoqGwZYm8K13cMn7dxzKNQkGqhMRjbTn2uHGVex1sX0H-PY4SyoqFNRrpfEfyfIS8ZXDDQKkPuQEQ0DCuFAj-jCyYFEMjed8-JwsA1jcKpLggr3J-rKscmHxJLjgoJluQC_LrNroDXcVxH3MoIU506Qsmup5cfMApzpm-X815G6aHq0y_HSaX4ojX1EyOrn8_IV-3OI-mxODoMpVtqqp8XYFqnRPSEundbrbRxlSCrVR-TV54s8v45jwvyY-P6--rT839l7vPq-V9YyWTpVHeeoDBetNDa7xyA7TKdNwLJ6TvbR1eug6GFq1xliFDY80GQPUM-nYjLgk7eW2erU5oMVlTdDTh33J8HDquBUiueM1cnTL7FH_OmIseQ7a425kJ6291J0TLW6a6St6c7SnmnNDrfQqjSQfNQB_70Vkf-9Hnfmrg3Vk9b0Z0T_jfQirQnICyDTiifoxzmuqB_if8A44Jmno</recordid><startdate>20100701</startdate><enddate>20100701</enddate><creator>Resmini, E.</creator><creator>Farkas, C.</creator><creator>Murillo, B.</creator><creator>Barahona, M. J.</creator><creator>Santos, A.</creator><creator>Martínez-Momblán, M. A.</creator><creator>Roig, O.</creator><creator>Ybarra, J.</creator><creator>Geli, C.</creator><creator>Webb, S. M.</creator><general>Georg Thieme Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>XX2</scope></search><sort><creationdate>20100701</creationdate><title>Body Composition After Endogenous (Cushing's Syndrome) and Exogenous (Rheumatoid Arthritis) Exposure to Glucocorticoids</title><author>Resmini, E. ; Farkas, C. ; Murillo, B. ; Barahona, M. J. ; Santos, A. ; Martínez-Momblán, M. A. ; Roig, O. ; Ybarra, J. ; Geli, C. ; Webb, S. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-5fcf009cfa806af5d9065a72f3d34f8c3d3f4d7096ecadc1e1eacab00581086b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Arthritis, Rheumatoid - drug therapy</topic><topic>Arthritis, Rheumatoid - physiopathology</topic><topic>Artritis reumatoide</topic><topic>Body composition</topic><topic>Body Composition - physiology</topic><topic>Case-Control Studies</topic><topic>Composició corporal</topic><topic>Cushing Syndrome - physiopathology</topic><topic>Cushing's syndrome</topic><topic>Estrogens - metabolism</topic><topic>Female</topic><topic>Glucocorticoides</topic><topic>Glucocorticoids</topic><topic>Glucocorticoids - therapeutic use</topic><topic>Growth Hormone - deficiency</topic><topic>Humans</topic><topic>Humans, Clinical</topic><topic>Middle Aged</topic><topic>Rheumatoid arthritis</topic><topic>Síndrome de Cushing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Resmini, E.</creatorcontrib><creatorcontrib>Farkas, C.</creatorcontrib><creatorcontrib>Murillo, B.</creatorcontrib><creatorcontrib>Barahona, M. J.</creatorcontrib><creatorcontrib>Santos, A.</creatorcontrib><creatorcontrib>Martínez-Momblán, M. A.</creatorcontrib><creatorcontrib>Roig, O.</creatorcontrib><creatorcontrib>Ybarra, J.</creatorcontrib><creatorcontrib>Geli, C.</creatorcontrib><creatorcontrib>Webb, S. M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Recercat</collection><jtitle>Hormone and metabolic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Resmini, E.</au><au>Farkas, C.</au><au>Murillo, B.</au><au>Barahona, M. J.</au><au>Santos, A.</au><au>Martínez-Momblán, M. A.</au><au>Roig, O.</au><au>Ybarra, J.</au><au>Geli, C.</au><au>Webb, S. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Body Composition After Endogenous (Cushing's Syndrome) and Exogenous (Rheumatoid Arthritis) Exposure to Glucocorticoids</atitle><jtitle>Hormone and metabolic research</jtitle><addtitle>Horm Metab Res</addtitle><date>2010-07-01</date><risdate>2010</risdate><volume>42</volume><issue>8</issue><spage>613</spage><epage>618</epage><pages>613-618</pages><issn>0018-5043</issn><eissn>1439-4286</eissn><abstract><![CDATA[Abstract
Exposure to chronic glucocorticoid (GC) excess determines changes in body composition. The aim of the study was to compare body composition in women exposed to endogenous hypercortisolism (Cushing's syndrome, CS), exogenous glucocorticoid treatment (rheumatoid arthritis, RA) and controls. Fifty-one CS women, 26 RA women treated with low-dose prednisone (5 mg/day or 10 mg/2 days), and 78 female controls were included. Fourteen CS patients were hypercortisolemic, 37 in remission (10 required hydrocortisone substitution after surgery). Body composition parameters were measured by dual-energy X-ray absorptiometry scanning (DEXA). RA patients had a greater waist-hip ratio (WHR) (p<0.01), less lean body mass (LBM) (p<0.01), and lumbar bone mineral density (BMD) (p<0.01) than controls. CS patients, globally and those with cured disease, had more total fat (both percentage and kg) and trunk fat percentage, and less whole body-BMD than RA patients (p<0.05, p<0.01, p<0.05, respectively). Active CS patients had less whole body-BMD and more LBM than RA patients (p<0.05, p=0.01, respectively). Cured CS patients not taking hydrocortisone had more total fat [both percentage (p<0.05) and kg (p<0.05)], trunk fat percentage (p<0.05), lumbar BMD (p<0.01) than RA patients. Cured CS patients requiring hydrocortisone only differed from RA patients by smaller WHR (p<0.01). All the differences in BMD disappeared when the data were reanalyzed including only the estrogen-deficient groups. Hypercortisoliof CS determines an irreversible increase in body fat, greater than in RA. Endogenous and exogenous exposure to GC negatively affects body composition by increasing the WHR. There appears to be no additional effect on BMD in estrogen-deficient women.]]></abstract><cop>Germany</cop><pub>Georg Thieme Verlag</pub><pmid>20514604</pmid><doi>10.1055/s-0030-1255032</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - physiopathology Artritis reumatoide Body composition Body Composition - physiology Case-Control Studies Composició corporal Cushing Syndrome - physiopathology Cushing's syndrome Estrogens - metabolism Female Glucocorticoides Glucocorticoids Glucocorticoids - therapeutic use Growth Hormone - deficiency Humans Humans, Clinical Middle Aged Rheumatoid arthritis Síndrome de Cushing |
| title | Body Composition After Endogenous (Cushing's Syndrome) and Exogenous (Rheumatoid Arthritis) Exposure to Glucocorticoids |
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