Dendritic Spine Abnormalities in Hippocampal CA1 Pyramidal Neurons Underlying Memory Deficits in the SAMP8 Mouse Model of Alzheimer's Disease

SAMP8 is a strain of mice with accelerated senescence. These mice have recently been the focus of attention as they show several alterations that have also been described in Alzheimer's disease (AD) patients. The number of dendritic spines, spine plasticity, and morphology are basic to memory f...

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Veröffentlicht in:	Journal of Alzheimer's disease 2012-01, Vol.32 (1), p.233-240
Hauptverfasser:	del Valle, Jaume, Bayod, Sergi, Camins, Antoni, Beas-Zárate, Carlos, Velázquez-Zamora, Dulce A., González-Burgos, Ignacio, Pallàs, Merce
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - psychology Alzheimer Disease - pathology Alzheimer Disease - psychology Alzheimer's disease Animal models Animals Attention Blotting, Western Brain - pathology CA1 Region, Hippocampal - pathology Cèl·lules dendrítiques Dendritic cells Dendritic spines Dendritic Spines - pathology Envelliment Hipocamp (Cervell) Hippocampus Hippocampus (Brain) Malaltia d'Alzheimer Malalties neurodegeneratives Male Memory Memory Disorders - pathology Memory Disorders - psychology Mice Mice, Transgenic Neurodegenerative diseases Neurones Neurons Neurotransmission Pattern recognition Plasticity (dendritic) Psychomotor Performance - physiology Pyramidal cells Pyramidal Cells - pathology Recognition (Psychology) - physiology Senescence Synaptophysin Synaptophysin - metabolism
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