New strategies in the modulation of fatty acid oxidation as a treatment for obesity
Strategies that enhance fat degradation or reduce caloricfood intake could be considered therapeutic interventions to reduce notonly obesity, but also its associated disorders. The enzyme carnitinepalmitoyltransferase 1 (CPT1) is the critical rate-determining regulatorof fatty acid oxidation (FAO) a...
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| creator | Herrero Rodríguez, Laura Mera Nanín, Paula Orellana Gavaldà, Josep Maria Gurunathan, Chandrashekaran Malandrino, Maria Ida Mir, Joan Francesc Makowski, Kamil Pozo, Macarena Arasa, Maria del Mar Ariza Piquer, Xavier Asins Muñoz, Guillermina García Gómez, Jordi García Hegardt, Fausto Serra i Cucurull, Dolors |
| description | Strategies that enhance fat degradation or reduce caloricfood intake could be considered therapeutic interventions to reduce notonly obesity, but also its associated disorders. The enzyme carnitinepalmitoyltransferase 1 (CPT1) is the critical rate-determining regulatorof fatty acid oxidation (FAO) and might play a key role in increasingenergy expenditure and controlling food intake. Our group has shownthat mice overexpressing CPT1 in liver are protected from weight gain,the development of obesity and insulin resistance. Regarding foodintake control, we observed that the pharmacological inhibition ofCPT1 in rat hypothalamus decreased food intake and body weight.This suggests that modulation of CPT1 activity and the oxidation offatty acids in various tissues can be crucial for the potential treatmentof obesity and associated pathologies.
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/46988 |
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| subjects | Investigació farmacèutica Obesitat Obesity Pharmaceutical research |
| title | New strategies in the modulation of fatty acid oxidation as a treatment for obesity |
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