BDNF impairment in the hippocampus is related to enhanced despair behavior in CB₁ knockout mice

Stress can cause damage and atrophy of neurons in the hippocampus by deregulating the expression of neurotrophic factors that promote neuronal plasticity. The endocannabinoid system represents a physiological substrate involved in neuroprotection at both cellular and emotional levels. The lack of CB...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of neurochemistry 2008-04, Vol.105 (2), p.565-572
Hauptverfasser:	Aso, Ester, Ozaita, Andrés, Valdizán, Elsa M, Ledent, Catherine, Pazos, Ángel, Maldonado, Rafael, Valverde, Olga
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animal behavior Animals BDNF Behavior, Animal Biochemistry Biological and medical sciences brain derived neurotrophic factor Brain-Derived Neurotrophic Factor - administration & dosage Brain-Derived Neurotrophic Factor - metabolism Cannabinoides CB1 cannabinoid receptor CB₁ cannabinoid receptor Cellular biology Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Corticosterone Corticosterone - blood CREB CREB-Binding Protein - metabolism cyclic AMP responsive element binding Estrès Freezing Reaction, Cataleptic - physiology Fundamental and applied biological sciences. Psychology Hindlimb Suspension - methods Hippocampus - pathology Humans Medical sciences Mice Mice, Knockout Miscellaneous Neurology Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Radioimmunoassay - methods Receptor, Cannabinoid, CB1 - deficiency Receptor, trkB - metabolism Receptors Rodents Stress Stress, Physiological - drug therapy Stress, Physiological - genetics Stress, Physiological - pathology Stress, Physiological - physiopathology TrkB tyrosine kinase receptor Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!