SEB-induced IL-13 production in CLA+ memory T cells defines Th2 high and Th2 low responders in atopic dermatitis
Atopic dermatitis; Cutaneous lymphocyte antigen; Skin infections Dermatitis atópica; Antígeno cutáneo de linfocitos; Infecciones de la piel Dermatitis atòpica; Antigen limfòcit cutani; Infeccions de la pell Staphylococcus aureus, memory skin-homing cutaneous lymphocyte-associated antigen (CLA)+ T ce...
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| creator | Sans De San Nicolàs, Lídia Figueras, Ignasi Bonfill Ortí, Montserrat Jesús Gil, Carmen de García-Jiménez, Irene Guilabert, Antonio |
| description | Atopic dermatitis; Cutaneous lymphocyte antigen; Skin infections
Dermatitis atópica; Antígeno cutáneo de linfocitos; Infecciones de la piel
Dermatitis atòpica; Antigen limfòcit cutani; Infeccions de la pell
Staphylococcus aureus, memory skin-homing cutaneous lymphocyte-associated antigen (CLA)+ T cells and IL-13 constitute relevant play-ers in atopic dermatitis (AD) pathogenesis.1 Since circulating CLA+ T cells reflect cutaneous abnormalities present in human inflammatory skin diseases,2 an ex vivo coculture model made of purified circu-lating CLA+/− effector and central memory T cells and autologous lesional epidermal cells was established. We show a CLA-dependent production of IL-13 upon activation with staphylococcal enterotoxin B (SEB) that allows the differentiation of the Th2 high and Th2 low groups, with distinct clinical correlations between both groups, within a clinically homogeneous population of adult non-treated moderate-to- severe AD patients. |
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Dermatitis atópica; Antígeno cutáneo de linfocitos; Infecciones de la piel
Dermatitis atòpica; Antigen limfòcit cutani; Infeccions de la pell
Staphylococcus aureus, memory skin-homing cutaneous lymphocyte-associated antigen (CLA)+ T cells and IL-13 constitute relevant play-ers in atopic dermatitis (AD) pathogenesis.1 Since circulating CLA+ T cells reflect cutaneous abnormalities present in human inflammatory skin diseases,2 an ex vivo coculture model made of purified circu-lating CLA+/− effector and central memory T cells and autologous lesional epidermal cells was established. We show a CLA-dependent production of IL-13 upon activation with staphylococcal enterotoxin B (SEB) that allows the differentiation of the Th2 high and Th2 low groups, with distinct clinical correlations between both groups, within a clinically homogeneous population of adult non-treated moderate-to- severe AD patients.</description><language>eng</language><publisher>Wiley</publisher><subject>ANATOMY ; ANATOMÍA ; Bacillales ; Bacteria ; Blood Cells ; Cells ; células ; células sanguíneas ; Dermatitis ; Dermatitis atòpica ; Dermatitis, Atopic ; dermatitis atópica ; DISEASES ; ENFERMEDADES ; enfermedades de la piel ; enfermedades de la piel y tejido conjuntivo ; Estafilococs daurats ; Firmicutes ; leucocitos ; leucocitos mononucleares ; Leukocytes ; Leukocytes, Mononuclear ; linfocitos ; linfocitos T ; Lymphocytes ; ORGANISMOS ; ORGANISMS ; Pell - Infeccions ; Skin and Connective Tissue Diseases ; Skin Diseases ; Staphylococcaceae ; Staphylococcus ; Staphylococcus aureus ; T-Lymphocytes</subject><creationdate>2022-06</creationdate><rights>Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,776,881,26951</link.rule.ids><linktorsrc>$$Uhttps://recercat.cat/handle/11351/8173$$EView_record_in_Consorci_de_Serveis_Universitaris_de_Catalunya_(CSUC)$$FView_record_in_$$GConsorci_de_Serveis_Universitaris_de_Catalunya_(CSUC)$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Sans De San Nicolàs, Lídia</creatorcontrib><creatorcontrib>Figueras, Ignasi</creatorcontrib><creatorcontrib>Bonfill Ortí, Montserrat</creatorcontrib><creatorcontrib>Jesús Gil, Carmen de</creatorcontrib><creatorcontrib>García-Jiménez, Irene</creatorcontrib><creatorcontrib>Guilabert, Antonio</creatorcontrib><title>SEB-induced IL-13 production in CLA+ memory T cells defines Th2 high and Th2 low responders in atopic dermatitis</title><description>Atopic dermatitis; Cutaneous lymphocyte antigen; Skin infections
Dermatitis atópica; Antígeno cutáneo de linfocitos; Infecciones de la piel
Dermatitis atòpica; Antigen limfòcit cutani; Infeccions de la pell
Staphylococcus aureus, memory skin-homing cutaneous lymphocyte-associated antigen (CLA)+ T cells and IL-13 constitute relevant play-ers in atopic dermatitis (AD) pathogenesis.1 Since circulating CLA+ T cells reflect cutaneous abnormalities present in human inflammatory skin diseases,2 an ex vivo coculture model made of purified circu-lating CLA+/− effector and central memory T cells and autologous lesional epidermal cells was established. We show a CLA-dependent production of IL-13 upon activation with staphylococcal enterotoxin B (SEB) that allows the differentiation of the Th2 high and Th2 low groups, with distinct clinical correlations between both groups, within a clinically homogeneous population of adult non-treated moderate-to- severe AD patients.</description><subject>ANATOMY</subject><subject>ANATOMÍA</subject><subject>Bacillales</subject><subject>Bacteria</subject><subject>Blood Cells</subject><subject>Cells</subject><subject>células</subject><subject>células sanguíneas</subject><subject>Dermatitis</subject><subject>Dermatitis atòpica</subject><subject>Dermatitis, Atopic</subject><subject>dermatitis atópica</subject><subject>DISEASES</subject><subject>ENFERMEDADES</subject><subject>enfermedades de la piel</subject><subject>enfermedades de la piel y tejido conjuntivo</subject><subject>Estafilococs daurats</subject><subject>Firmicutes</subject><subject>leucocitos</subject><subject>leucocitos mononucleares</subject><subject>Leukocytes</subject><subject>Leukocytes, Mononuclear</subject><subject>linfocitos</subject><subject>linfocitos T</subject><subject>Lymphocytes</subject><subject>ORGANISMOS</subject><subject>ORGANISMS</subject><subject>Pell - Infeccions</subject><subject>Skin and Connective Tissue Diseases</subject><subject>Skin Diseases</subject><subject>Staphylococcaceae</subject><subject>Staphylococcus</subject><subject>Staphylococcus aureus</subject><subject>T-Lymphocytes</subject><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>XX2</sourceid><recordid>eNqdy7EKwjAUheEuDqK-w92lYAyiq5aKQje7l5DcthfS3JCkiG9vK4K7w-HwD98y84_ykpMzo0YD9yoXEnzgKROxA3JQVOctDDhweEENGq2NYLAlhxHqfg89dT0oZz5h-QkBo2dnMMSZq8Se9CTCoBIliuts0SobcfP9Vba7lnVxy3UcdRNQY9AqNazoF_OEkAfRnMRRyj_IGz0dTSI</recordid><startdate>20220630</startdate><enddate>20220630</enddate><creator>Sans De San Nicolàs, Lídia</creator><creator>Figueras, Ignasi</creator><creator>Bonfill Ortí, Montserrat</creator><creator>Jesús Gil, Carmen de</creator><creator>García-Jiménez, Irene</creator><creator>Guilabert, Antonio</creator><general>Wiley</general><scope>XX2</scope></search><sort><creationdate>20220630</creationdate><title>SEB-induced IL-13 production in CLA+ memory T cells defines Th2 high and Th2 low responders in atopic dermatitis</title><author>Sans De San Nicolàs, Lídia ; Figueras, Ignasi ; Bonfill Ortí, Montserrat ; Jesús Gil, Carmen de ; García-Jiménez, Irene ; Guilabert, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-csuc_recercat_oai_recercat_cat_11351_81733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>ANATOMY</topic><topic>ANATOMÍA</topic><topic>Bacillales</topic><topic>Bacteria</topic><topic>Blood Cells</topic><topic>Cells</topic><topic>células</topic><topic>células sanguíneas</topic><topic>Dermatitis</topic><topic>Dermatitis atòpica</topic><topic>Dermatitis, Atopic</topic><topic>dermatitis atópica</topic><topic>DISEASES</topic><topic>ENFERMEDADES</topic><topic>enfermedades de la piel</topic><topic>enfermedades de la piel y tejido conjuntivo</topic><topic>Estafilococs daurats</topic><topic>Firmicutes</topic><topic>leucocitos</topic><topic>leucocitos mononucleares</topic><topic>Leukocytes</topic><topic>Leukocytes, Mononuclear</topic><topic>linfocitos</topic><topic>linfocitos T</topic><topic>Lymphocytes</topic><topic>ORGANISMOS</topic><topic>ORGANISMS</topic><topic>Pell - Infeccions</topic><topic>Skin and Connective Tissue Diseases</topic><topic>Skin Diseases</topic><topic>Staphylococcaceae</topic><topic>Staphylococcus</topic><topic>Staphylococcus aureus</topic><topic>T-Lymphocytes</topic><toplevel>online_resources</toplevel><creatorcontrib>Sans De San Nicolàs, Lídia</creatorcontrib><creatorcontrib>Figueras, Ignasi</creatorcontrib><creatorcontrib>Bonfill Ortí, Montserrat</creatorcontrib><creatorcontrib>Jesús Gil, Carmen de</creatorcontrib><creatorcontrib>García-Jiménez, Irene</creatorcontrib><creatorcontrib>Guilabert, Antonio</creatorcontrib><collection>Recercat</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Sans De San Nicolàs, Lídia</au><au>Figueras, Ignasi</au><au>Bonfill Ortí, Montserrat</au><au>Jesús Gil, Carmen de</au><au>García-Jiménez, Irene</au><au>Guilabert, Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SEB-induced IL-13 production in CLA+ memory T cells defines Th2 high and Th2 low responders in atopic dermatitis</atitle><date>2022-06-30</date><risdate>2022</risdate><abstract>Atopic dermatitis; Cutaneous lymphocyte antigen; Skin infections
Dermatitis atópica; Antígeno cutáneo de linfocitos; Infecciones de la piel
Dermatitis atòpica; Antigen limfòcit cutani; Infeccions de la pell
Staphylococcus aureus, memory skin-homing cutaneous lymphocyte-associated antigen (CLA)+ T cells and IL-13 constitute relevant play-ers in atopic dermatitis (AD) pathogenesis.1 Since circulating CLA+ T cells reflect cutaneous abnormalities present in human inflammatory skin diseases,2 an ex vivo coculture model made of purified circu-lating CLA+/− effector and central memory T cells and autologous lesional epidermal cells was established. We show a CLA-dependent production of IL-13 upon activation with staphylococcal enterotoxin B (SEB) that allows the differentiation of the Th2 high and Th2 low groups, with distinct clinical correlations between both groups, within a clinically homogeneous population of adult non-treated moderate-to- severe AD patients.</abstract><pub>Wiley</pub><oa>free_for_read</oa></addata></record> |
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| source | Recercat |
| subjects | ANATOMY ANATOMÍA Bacillales Bacteria Blood Cells Cells células células sanguíneas Dermatitis Dermatitis atòpica Dermatitis, Atopic dermatitis atópica DISEASES ENFERMEDADES enfermedades de la piel enfermedades de la piel y tejido conjuntivo Estafilococs daurats Firmicutes leucocitos leucocitos mononucleares Leukocytes Leukocytes, Mononuclear linfocitos linfocitos T Lymphocytes ORGANISMOS ORGANISMS Pell - Infeccions Skin and Connective Tissue Diseases Skin Diseases Staphylococcaceae Staphylococcus Staphylococcus aureus T-Lymphocytes |
| title | SEB-induced IL-13 production in CLA+ memory T cells defines Th2 high and Th2 low responders in atopic dermatitis |
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