Deciphering predictive factors for choice of thrombopoietin receptor agonist, treatment free responses, and thrombotic events in immune thrombocytopenia

Malalties hematològiques; Trastorns immunològics Enfermedades hematológicas; Trastornos inmunológicos Haematological diseases; Immunological disorders Very few data exist on when a particular thrombopoietin-receptor agonist (TPO-RA) is favored in clinical practice for the treatment of patients with...

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Hauptverfasser: Lozano, Maria L, Mingot-Castellano, Maria E, Perera, María M, Jarque, Isidro, Campos-Alvarez, Rosa M, González-López, Tomás J, Valcarcel Ferreiras, David
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creator Lozano, Maria L
Mingot-Castellano, Maria E
Perera, María M
Jarque, Isidro
Campos-Alvarez, Rosa M
González-López, Tomás J
Valcarcel Ferreiras, David
description Malalties hematològiques; Trastorns immunològics Enfermedades hematológicas; Trastornos inmunológicos Haematological diseases; Immunological disorders Very few data exist on when a particular thrombopoietin-receptor agonist (TPO-RA) is favored in clinical practice for the treatment of patients with immune thrombocytopenia (ITP), about novel risk factors for vascular events (VE) with these drugs, nor about predictive factors for therapy free responses (TFR). We conducted an observational, retrospective, long-term follow-up multicenter study from November 2016 to January 2018 of 121 adult ITP patients initiating TPO-RA between January 2012 to December 2014. Data reflected that a platelet count ≤25 × 109/l at the time when the TPO-RA was initiated was associated with a 2.8 higher probability of receiving romiplostim vs. eltrombopag (P = 0.010). VE on TPO-RA was related to previous neoplasia in patients over 65 years (50% vs. 2.2%, P 
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source Recercat
subjects Blood Coagulation Disorders
DISEASES
drug therapy
ENFERMEDADES
enfermedades hematológicas
enfermedades hematológicas y linfáticas
farmacoterapia
Hematologic Diseases
Hemic and Lymphatic Diseases
Medicaments - Administració
Other subheadings
Otros calificadores
Purpura
Purpura, Thrombocytopenic
Purpura, Thrombocytopenic, Idiopathic
púrpura
púrpura trombocitopénica
púrpura trombocitopénica idiopática
trastornos de la coagulación sanguínea
Trombocitopènia
title Deciphering predictive factors for choice of thrombopoietin receptor agonist, treatment free responses, and thrombotic events in immune thrombocytopenia
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