Antimicrobial and antibiofilm activities of aqueous extracts of Cucurbita pepo L
Introduction: Cucurbita pepo L. is an herbaceous plant belonging to the family Cucurbitaceae. The species is popularly used in different countries for the treatment of diabetes and parasitic diseases. Objective: This study evaluated the antimicrobial and antibiofilm potential of aqueous extracts of...
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| Veröffentlicht in: | Revista ciências médicas e biológicas 2020-09, Vol.19 (2), p.270 |
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| creator | Silva, Ivanise Brito da Sá, Rafaela Damasceno Moura, Maiara Celine de Coelho, Luana Cassandra Breitenbach Barroso Randau, Karina Perrelli |
| description | Introduction: Cucurbita pepo L. is an herbaceous plant belonging to the family Cucurbitaceae. The species is popularly used in different
countries for the treatment of diabetes and parasitic diseases. Objective: This study evaluated the antimicrobial and antibiofilm
potential of aqueous extracts of leaves and seeds of C. pepo. Methodology: the extracts were tested in vitro against strains of
Streptococcus pyogenes, Candida albicans and Candida krusei. The antimicrobial activity was performed by the microtiter method and
the antibiofilm activity by the violet crystal method. Results: the results demonstrated that the extracts tested showed antibacterial
and antibiofilm actions against S. pyogenes, but it was not possible to determine the minimum inhibitory concentration (MIC). The
extracts inhibited the growth of C. albicans and C. krusei with MIC of 0.03 mg/mL. The antibiofilm activity of these species did not
present either a dose dependence relationship or a synergistic effect when associated with the antifungal Fluconazole®. Conclusion:
although there are indications of antimicrobial and inhibitory action in the formation of biofilm, additional studies are necessary to
characterize the possible pharmacological effects of the analyzed specie |
| doi_str_mv | 10.9771/cmbio.v19i2.32895 |
| format | Article |
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countries for the treatment of diabetes and parasitic diseases. Objective: This study evaluated the antimicrobial and antibiofilm
potential of aqueous extracts of leaves and seeds of C. pepo. Methodology: the extracts were tested in vitro against strains of
Streptococcus pyogenes, Candida albicans and Candida krusei. The antimicrobial activity was performed by the microtiter method and
the antibiofilm activity by the violet crystal method. Results: the results demonstrated that the extracts tested showed antibacterial
and antibiofilm actions against S. pyogenes, but it was not possible to determine the minimum inhibitory concentration (MIC). The
extracts inhibited the growth of C. albicans and C. krusei with MIC of 0.03 mg/mL. The antibiofilm activity of these species did not
present either a dose dependence relationship or a synergistic effect when associated with the antifungal Fluconazole®. Conclusion:
although there are indications of antimicrobial and inhibitory action in the formation of biofilm, additional studies are necessary to
characterize the possible pharmacological effects of the analyzed specie</description><identifier>ISSN: 1677-5090</identifier><identifier>EISSN: 2236-5222</identifier><identifier>DOI: 10.9771/cmbio.v19i2.32895</identifier><language>eng</language><ispartof>Revista ciências médicas e biológicas, 2020-09, Vol.19 (2), p.270</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27915,27916</link.rule.ids></links><search><creatorcontrib>Silva, Ivanise Brito da</creatorcontrib><creatorcontrib>Sá, Rafaela Damasceno</creatorcontrib><creatorcontrib>Moura, Maiara Celine de</creatorcontrib><creatorcontrib>Coelho, Luana Cassandra Breitenbach Barroso</creatorcontrib><creatorcontrib>Randau, Karina Perrelli</creatorcontrib><title>Antimicrobial and antibiofilm activities of aqueous extracts of Cucurbita pepo L</title><title>Revista ciências médicas e biológicas</title><description>Introduction: Cucurbita pepo L. is an herbaceous plant belonging to the family Cucurbitaceae. The species is popularly used in different
countries for the treatment of diabetes and parasitic diseases. Objective: This study evaluated the antimicrobial and antibiofilm
potential of aqueous extracts of leaves and seeds of C. pepo. Methodology: the extracts were tested in vitro against strains of
Streptococcus pyogenes, Candida albicans and Candida krusei. The antimicrobial activity was performed by the microtiter method and
the antibiofilm activity by the violet crystal method. Results: the results demonstrated that the extracts tested showed antibacterial
and antibiofilm actions against S. pyogenes, but it was not possible to determine the minimum inhibitory concentration (MIC). The
extracts inhibited the growth of C. albicans and C. krusei with MIC of 0.03 mg/mL. The antibiofilm activity of these species did not
present either a dose dependence relationship or a synergistic effect when associated with the antifungal Fluconazole®. Conclusion:
although there are indications of antimicrobial and inhibitory action in the formation of biofilm, additional studies are necessary to
characterize the possible pharmacological effects of the analyzed specie</description><issn>1677-5090</issn><issn>2236-5222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqdjkEKwjAQRYMoWLQHcJcLtCYpbexSRHHhwoX7kMYURtqmJmnR2xuLJ3BgGPif-f8htKEkLTmnW9VWYNKRlsDSjO3KfIYixrIiyRljcxTRgvMkJyVZoti5BwmTFxkreISu-85DC8qaCmSDZXcP6yHk1dC0WCoPI3jQDpsay-egzeCwfnkbnEk7DGqwFXiJe90bfFmjRS0bp-PfXSF6Ot4O5yRUOGd1LXoLrbRvQYn40ouJXkz0YqLP_vn5AJjiUVY</recordid><startdate>20200924</startdate><enddate>20200924</enddate><creator>Silva, Ivanise Brito da</creator><creator>Sá, Rafaela Damasceno</creator><creator>Moura, Maiara Celine de</creator><creator>Coelho, Luana Cassandra Breitenbach Barroso</creator><creator>Randau, Karina Perrelli</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20200924</creationdate><title>Antimicrobial and antibiofilm activities of aqueous extracts of Cucurbita pepo L</title><author>Silva, Ivanise Brito da ; Sá, Rafaela Damasceno ; Moura, Maiara Celine de ; Coelho, Luana Cassandra Breitenbach Barroso ; Randau, Karina Perrelli</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-crossref_primary_10_9771_cmbio_v19i2_328953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Silva, Ivanise Brito da</creatorcontrib><creatorcontrib>Sá, Rafaela Damasceno</creatorcontrib><creatorcontrib>Moura, Maiara Celine de</creatorcontrib><creatorcontrib>Coelho, Luana Cassandra Breitenbach Barroso</creatorcontrib><creatorcontrib>Randau, Karina Perrelli</creatorcontrib><collection>CrossRef</collection><jtitle>Revista ciências médicas e biológicas</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silva, Ivanise Brito da</au><au>Sá, Rafaela Damasceno</au><au>Moura, Maiara Celine de</au><au>Coelho, Luana Cassandra Breitenbach Barroso</au><au>Randau, Karina Perrelli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimicrobial and antibiofilm activities of aqueous extracts of Cucurbita pepo L</atitle><jtitle>Revista ciências médicas e biológicas</jtitle><date>2020-09-24</date><risdate>2020</risdate><volume>19</volume><issue>2</issue><spage>270</spage><pages>270-</pages><issn>1677-5090</issn><eissn>2236-5222</eissn><abstract>Introduction: Cucurbita pepo L. is an herbaceous plant belonging to the family Cucurbitaceae. The species is popularly used in different
countries for the treatment of diabetes and parasitic diseases. Objective: This study evaluated the antimicrobial and antibiofilm
potential of aqueous extracts of leaves and seeds of C. pepo. Methodology: the extracts were tested in vitro against strains of
Streptococcus pyogenes, Candida albicans and Candida krusei. The antimicrobial activity was performed by the microtiter method and
the antibiofilm activity by the violet crystal method. Results: the results demonstrated that the extracts tested showed antibacterial
and antibiofilm actions against S. pyogenes, but it was not possible to determine the minimum inhibitory concentration (MIC). The
extracts inhibited the growth of C. albicans and C. krusei with MIC of 0.03 mg/mL. The antibiofilm activity of these species did not
present either a dose dependence relationship or a synergistic effect when associated with the antifungal Fluconazole®. Conclusion:
although there are indications of antimicrobial and inhibitory action in the formation of biofilm, additional studies are necessary to
characterize the possible pharmacological effects of the analyzed specie</abstract><doi>10.9771/cmbio.v19i2.32895</doi></addata></record> |
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| language | eng |
| recordid | cdi_crossref_primary_10_9771_cmbio_v19i2_32895 |
| source | Alma/SFX Local Collection |
| title | Antimicrobial and antibiofilm activities of aqueous extracts of Cucurbita pepo L |
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