Trends of Antibacterial Interactions in Multidrug – Resistant Isolates: Exploring Resistance Phenotypes in the Ndé Division, West-Cameroon
Background: Reliable pieces of information concerning bacterial-antibiotic interactions are key assets for therapeutic management of bacterial diseases. Objective: The present study aimed at detecting phenotypic characteristics of bacterial resistance in multidrug-resistant isolates recovered from c...
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| Veröffentlicht in: | Microbiology Research Journal International 2024-03, Vol.34 (2), p.9-22 |
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| container_title | Microbiology Research Journal International |
| container_volume | 34 |
| creator | Tangueu, Vanessa Ornella Alactio Youté, O’Neal Dorsel Kweyang, Blandine Pulchérie Tamatcho Nana, Vanessa Flora Yomi Kwetche, Pierre René Fotsing |
| description | Background: Reliable pieces of information concerning bacterial-antibiotic interactions are key assets for therapeutic management of bacterial diseases.
Objective: The present study aimed at detecting phenotypic characteristics of bacterial resistance in multidrug-resistant isolates recovered from clinical specimens at the “Université des Montagnes” Teaching Hospital.
Methods: The total of 226 isolates (142 Gram-negative rods and 84 Gram-positive cocci) were subjected to phenotypic screening of resistance mechanisms. All procedural steps were conducted according to standard protocols on bacterial susceptibility to antibiotics.
Results: Primary pieces of information revealed high rates of resistant isolates, especially with beta-lactams and Trimethoprim/Sulfamethoxazole while Nitrofurantoin and Imipenem were most effective. Amongst Gram-negative rods, 56% expressed one enzymatic resistance mechanism and 12% expressed two against beta-lactams. Also, with extended spectrum beta-lactamases, high level cephalosporinases and inducible cephalosporinases most commonly observed. About 62% and 14% of Gram-positive cocci expressed constitutive and Clindamycin-inducible resistance, respectively. Decreased susceptibility to Ceftriaxone and Penicillin G was also recorded in suspect mutant isolates selected by these antibiotics. Potential synergetic and other antagonistic interactions were evenly detected.
Conclusion: Overall, the data could represent reliable clue for advocacy about personalized combination therapy, then capacity building for routine affordable susceptibility tests in caretaking. |
| doi_str_mv | 10.9734/mrji/2024/v34i21427 |
| format | Article |
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Objective: The present study aimed at detecting phenotypic characteristics of bacterial resistance in multidrug-resistant isolates recovered from clinical specimens at the “Université des Montagnes” Teaching Hospital.
Methods: The total of 226 isolates (142 Gram-negative rods and 84 Gram-positive cocci) were subjected to phenotypic screening of resistance mechanisms. All procedural steps were conducted according to standard protocols on bacterial susceptibility to antibiotics.
Results: Primary pieces of information revealed high rates of resistant isolates, especially with beta-lactams and Trimethoprim/Sulfamethoxazole while Nitrofurantoin and Imipenem were most effective. Amongst Gram-negative rods, 56% expressed one enzymatic resistance mechanism and 12% expressed two against beta-lactams. Also, with extended spectrum beta-lactamases, high level cephalosporinases and inducible cephalosporinases most commonly observed. About 62% and 14% of Gram-positive cocci expressed constitutive and Clindamycin-inducible resistance, respectively. Decreased susceptibility to Ceftriaxone and Penicillin G was also recorded in suspect mutant isolates selected by these antibiotics. Potential synergetic and other antagonistic interactions were evenly detected.
Conclusion: Overall, the data could represent reliable clue for advocacy about personalized combination therapy, then capacity building for routine affordable susceptibility tests in caretaking.</description><identifier>ISSN: 2456-7043</identifier><identifier>EISSN: 2456-7043</identifier><identifier>DOI: 10.9734/mrji/2024/v34i21427</identifier><language>eng</language><ispartof>Microbiology Research Journal International, 2024-03, Vol.34 (2), p.9-22</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids></links><search><creatorcontrib>Tangueu, Vanessa Ornella Alactio</creatorcontrib><creatorcontrib>Youté, O’Neal Dorsel</creatorcontrib><creatorcontrib>Kweyang, Blandine Pulchérie Tamatcho</creatorcontrib><creatorcontrib>Nana, Vanessa Flora Yomi</creatorcontrib><creatorcontrib>Kwetche, Pierre René Fotsing</creatorcontrib><title>Trends of Antibacterial Interactions in Multidrug – Resistant Isolates: Exploring Resistance Phenotypes in the Ndé Division, West-Cameroon</title><title>Microbiology Research Journal International</title><description>Background: Reliable pieces of information concerning bacterial-antibiotic interactions are key assets for therapeutic management of bacterial diseases.
Objective: The present study aimed at detecting phenotypic characteristics of bacterial resistance in multidrug-resistant isolates recovered from clinical specimens at the “Université des Montagnes” Teaching Hospital.
Methods: The total of 226 isolates (142 Gram-negative rods and 84 Gram-positive cocci) were subjected to phenotypic screening of resistance mechanisms. All procedural steps were conducted according to standard protocols on bacterial susceptibility to antibiotics.
Results: Primary pieces of information revealed high rates of resistant isolates, especially with beta-lactams and Trimethoprim/Sulfamethoxazole while Nitrofurantoin and Imipenem were most effective. Amongst Gram-negative rods, 56% expressed one enzymatic resistance mechanism and 12% expressed two against beta-lactams. Also, with extended spectrum beta-lactamases, high level cephalosporinases and inducible cephalosporinases most commonly observed. About 62% and 14% of Gram-positive cocci expressed constitutive and Clindamycin-inducible resistance, respectively. Decreased susceptibility to Ceftriaxone and Penicillin G was also recorded in suspect mutant isolates selected by these antibiotics. Potential synergetic and other antagonistic interactions were evenly detected.
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Objective: The present study aimed at detecting phenotypic characteristics of bacterial resistance in multidrug-resistant isolates recovered from clinical specimens at the “Université des Montagnes” Teaching Hospital.
Methods: The total of 226 isolates (142 Gram-negative rods and 84 Gram-positive cocci) were subjected to phenotypic screening of resistance mechanisms. All procedural steps were conducted according to standard protocols on bacterial susceptibility to antibiotics.
Results: Primary pieces of information revealed high rates of resistant isolates, especially with beta-lactams and Trimethoprim/Sulfamethoxazole while Nitrofurantoin and Imipenem were most effective. Amongst Gram-negative rods, 56% expressed one enzymatic resistance mechanism and 12% expressed two against beta-lactams. Also, with extended spectrum beta-lactamases, high level cephalosporinases and inducible cephalosporinases most commonly observed. About 62% and 14% of Gram-positive cocci expressed constitutive and Clindamycin-inducible resistance, respectively. Decreased susceptibility to Ceftriaxone and Penicillin G was also recorded in suspect mutant isolates selected by these antibiotics. Potential synergetic and other antagonistic interactions were evenly detected.
Conclusion: Overall, the data could represent reliable clue for advocacy about personalized combination therapy, then capacity building for routine affordable susceptibility tests in caretaking.</abstract><doi>10.9734/mrji/2024/v34i21427</doi></addata></record> |
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| title | Trends of Antibacterial Interactions in Multidrug – Resistant Isolates: Exploring Resistance Phenotypes in the Ndé Division, West-Cameroon |
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