Potent Suppressive Activity of Chlorophyll a and b from Green Tea (Camellia sinensis) against Tumor Promotion in Mouse Skin
Potent antigenotoxic and anti-tumor promoting activities of chlorophyll a from green tea (camellia sinensis) have been shown using in vitro cell culture experiments (Okai Y. et al. (1996) Mutation Res., 370, 11-17). In the present study, the authors analyzed in vivo effects of chlorophyll a and b fr...
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| Veröffentlicht in: | Journal of UOEH 1998/09/01, Vol.20(3), pp.181-188 |
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| creator | HIGASHI-OKAI, Kiyoka OKAI, Yasuji |
| description | Potent antigenotoxic and anti-tumor promoting activities of chlorophyll a from green tea (camellia sinensis) have been shown using in vitro cell culture experiments (Okai Y. et al. (1996) Mutation Res., 370, 11-17). In the present study, the authors analyzed in vivo effects of chlorophyll a and b from green tea on tumor promotion in mouse skin in the following ways. 1. When chlorophyll a and b from green tea were applied before each treatment by a tumor promoter, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on BALB/c mouse skin initiated by 7, 12-dimethylbenz [a] an-thracene (DMBA), they caused significant suppression in a dose-dependent manner against BALB/c mouse skin tumorigenesis. 2. Chlorophyll a and b showed significant suppressive effects against TPA-induced inflammatory reaction such as edema formation in BALB/c mouse ear skin in a dose-dependent fashion. These results suggest that chlorophyll a and b possess potent suppressive activities against tumor promotion in mouse skin. |
| doi_str_mv | 10.7888/juoeh.20.181 |
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(1996) Mutation Res., 370, 11-17). In the present study, the authors analyzed in vivo effects of chlorophyll a and b from green tea on tumor promotion in mouse skin in the following ways. 1. When chlorophyll a and b from green tea were applied before each treatment by a tumor promoter, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on BALB/c mouse skin initiated by 7, 12-dimethylbenz [a] an-thracene (DMBA), they caused significant suppression in a dose-dependent manner against BALB/c mouse skin tumorigenesis. 2. Chlorophyll a and b showed significant suppressive effects against TPA-induced inflammatory reaction such as edema formation in BALB/c mouse ear skin in a dose-dependent fashion. These results suggest that chlorophyll a and b possess potent suppressive activities against tumor promotion in mouse skin.</description><identifier>ISSN: 0387-821X</identifier><identifier>EISSN: 2187-2864</identifier><identifier>DOI: 10.7888/juoeh.20.181</identifier><identifier>PMID: 9760704</identifier><language>eng</language><publisher>Japan: The University of Occupational and Environmental Health, Japan</publisher><subject><![CDATA[9,10-Dimethyl-1,2-benzanthracene ; Animals ; Carcinogens - antagonists & inhibitors ; chlorophyll ; Chlorophyll - isolation & purification ; Chlorophyll - pharmacology ; Edema - prevention & control ; green tea ; Mice ; Mice, Inbred BALB C ; mouse skin ; Pigments, Biological - isolation & purification ; Pigments, Biological - pharmacology ; Skin Neoplasms - prevention & control ; suppression of tumor promotion ; Tea - chemistry ; Tetradecanoylphorbol Acetate - antagonists & inhibitors ; TPA]]></subject><ispartof>Journal of UOEH, 1998/09/01, Vol.20(3), pp.181-188</ispartof><rights>1998 The University of Occupational and Environmental Health, Japan</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3681-bc39c42acd26f1a13c47b096232a847f9488d6d86a63b0530fe39e3fdd5a3b0d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9760704$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HIGASHI-OKAI, Kiyoka</creatorcontrib><creatorcontrib>OKAI, Yasuji</creatorcontrib><creatorcontrib>Osaka Kun-Ei Women's College</creatorcontrib><creatorcontrib>Department of Human Life Science</creatorcontrib><title>Potent Suppressive Activity of Chlorophyll a and b from Green Tea (Camellia sinensis) against Tumor Promotion in Mouse Skin</title><title>Journal of UOEH</title><addtitle>J UOEH</addtitle><description>Potent antigenotoxic and anti-tumor promoting activities of chlorophyll a from green tea (camellia sinensis) have been shown using in vitro cell culture experiments (Okai Y. et al. (1996) Mutation Res., 370, 11-17). In the present study, the authors analyzed in vivo effects of chlorophyll a and b from green tea on tumor promotion in mouse skin in the following ways. 1. When chlorophyll a and b from green tea were applied before each treatment by a tumor promoter, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on BALB/c mouse skin initiated by 7, 12-dimethylbenz [a] an-thracene (DMBA), they caused significant suppression in a dose-dependent manner against BALB/c mouse skin tumorigenesis. 2. Chlorophyll a and b showed significant suppressive effects against TPA-induced inflammatory reaction such as edema formation in BALB/c mouse ear skin in a dose-dependent fashion. These results suggest that chlorophyll a and b possess potent suppressive activities against tumor promotion in mouse skin.</description><subject>9,10-Dimethyl-1,2-benzanthracene</subject><subject>Animals</subject><subject>Carcinogens - antagonists & inhibitors</subject><subject>chlorophyll</subject><subject>Chlorophyll - isolation & purification</subject><subject>Chlorophyll - pharmacology</subject><subject>Edema - prevention & control</subject><subject>green tea</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>mouse skin</subject><subject>Pigments, Biological - isolation & purification</subject><subject>Pigments, Biological - pharmacology</subject><subject>Skin Neoplasms - prevention & control</subject><subject>suppression of tumor promotion</subject><subject>Tea - chemistry</subject><subject>Tetradecanoylphorbol Acetate - antagonists & inhibitors</subject><subject>TPA</subject><issn>0387-821X</issn><issn>2187-2864</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFv2yAUxtG0qcu63XadxHGTmvQBNsbHKlq7dq1WqZm0G8KAGzIbLLArRf3nR-oq4_Ae4vv4wfsQ-kxgVQkhzndTsNsVhRUR5A1aUCKqJRW8eIsWwPJeUPLnPfqQ0g6gFAUpT9BJXXGooFig5_swWj_ih2kYok3JPVl8oUf35MY9Di1eb7sQw7Dddx1WWHmDG9zG0OOraK3HG6vw17Xqbdc5hZPz1ieXvmH1qJxPI95MfYj4Pl8IowseO4_vwpQsfvjr_Ef0rlVdsp9e-yn6ffl9s_6xvP11db2-uF1qxgVZNprVuqBKG8pbogjTRdVAzSmjShRVWxdCGG4EV5w1UDJoLasta40pVT4w7BSdzVwdQ0rRtnKIrldxLwnIQ4TyJUJJQeYIs_3LbB-mprfmaH7NLOuXs55Fp1UXfJfnlrswRZ_HkEaXM4_UtZAAFIDlRiRk-qGIqiSZlEHXM2iXRvVojw-pODrd2f-_Yofy8wbyIrwUQOnRo7cqSuvZP8EJni0</recordid><startdate>19980901</startdate><enddate>19980901</enddate><creator>HIGASHI-OKAI, Kiyoka</creator><creator>OKAI, Yasuji</creator><general>The University of Occupational and Environmental Health, Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19980901</creationdate><title>Potent Suppressive Activity of Chlorophyll a and b from Green Tea (Camellia sinensis) against Tumor Promotion in Mouse Skin</title><author>HIGASHI-OKAI, Kiyoka ; OKAI, Yasuji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3681-bc39c42acd26f1a13c47b096232a847f9488d6d86a63b0530fe39e3fdd5a3b0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>9,10-Dimethyl-1,2-benzanthracene</topic><topic>Animals</topic><topic>Carcinogens - antagonists & inhibitors</topic><topic>chlorophyll</topic><topic>Chlorophyll - isolation & purification</topic><topic>Chlorophyll - pharmacology</topic><topic>Edema - prevention & control</topic><topic>green tea</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>mouse skin</topic><topic>Pigments, Biological - isolation & purification</topic><topic>Pigments, Biological - pharmacology</topic><topic>Skin Neoplasms - prevention & control</topic><topic>suppression of tumor promotion</topic><topic>Tea - chemistry</topic><topic>Tetradecanoylphorbol Acetate - antagonists & inhibitors</topic><topic>TPA</topic><toplevel>online_resources</toplevel><creatorcontrib>HIGASHI-OKAI, Kiyoka</creatorcontrib><creatorcontrib>OKAI, Yasuji</creatorcontrib><creatorcontrib>Osaka Kun-Ei Women's College</creatorcontrib><creatorcontrib>Department of Human Life Science</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of UOEH</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HIGASHI-OKAI, Kiyoka</au><au>OKAI, Yasuji</au><aucorp>Osaka Kun-Ei Women's College</aucorp><aucorp>Department of Human Life Science</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potent Suppressive Activity of Chlorophyll a and b from Green Tea (Camellia sinensis) against Tumor Promotion in Mouse Skin</atitle><jtitle>Journal of UOEH</jtitle><addtitle>J UOEH</addtitle><date>1998-09-01</date><risdate>1998</risdate><volume>20</volume><issue>3</issue><spage>181</spage><epage>188</epage><pages>181-188</pages><issn>0387-821X</issn><eissn>2187-2864</eissn><abstract>Potent antigenotoxic and anti-tumor promoting activities of chlorophyll a from green tea (camellia sinensis) have been shown using in vitro cell culture experiments (Okai Y. et al. (1996) Mutation Res., 370, 11-17). In the present study, the authors analyzed in vivo effects of chlorophyll a and b from green tea on tumor promotion in mouse skin in the following ways. 1. When chlorophyll a and b from green tea were applied before each treatment by a tumor promoter, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on BALB/c mouse skin initiated by 7, 12-dimethylbenz [a] an-thracene (DMBA), they caused significant suppression in a dose-dependent manner against BALB/c mouse skin tumorigenesis. 2. Chlorophyll a and b showed significant suppressive effects against TPA-induced inflammatory reaction such as edema formation in BALB/c mouse ear skin in a dose-dependent fashion. These results suggest that chlorophyll a and b possess potent suppressive activities against tumor promotion in mouse skin.</abstract><cop>Japan</cop><pub>The University of Occupational and Environmental Health, Japan</pub><pmid>9760704</pmid><doi>10.7888/juoeh.20.181</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | 9,10-Dimethyl-1,2-benzanthracene Animals Carcinogens - antagonists & inhibitors chlorophyll Chlorophyll - isolation & purification Chlorophyll - pharmacology Edema - prevention & control green tea Mice Mice, Inbred BALB C mouse skin Pigments, Biological - isolation & purification Pigments, Biological - pharmacology Skin Neoplasms - prevention & control suppression of tumor promotion Tea - chemistry Tetradecanoylphorbol Acetate - antagonists & inhibitors TPA |
| title | Potent Suppressive Activity of Chlorophyll a and b from Green Tea (Camellia sinensis) against Tumor Promotion in Mouse Skin |
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