Low-autofluorescence fluoropolymer membrane filters for cell filtration

A fluoropolymer membrane filter with through-holes was fabricated by photolithographic patterning and the dry etching method. 380,000 highly packed through-holes, each with a diameter of 7 µm were able to cover a whole area with a diameter of 13 mm. Ethylene tetrafluoroethylene (ETFE) was used as th...

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Veröffentlicht in:Japanese Journal of Applied Physics 2018-06, Vol.57 (6S2), p.6
Hauptverfasser: Kihara, Naoto, Kuboyama, Daiki, Onoshima, Daisuke, Ishikawa, Kenji, Tanaka, Hiromasa, Ozawa, Naoya, Hase, Tetsunari, Koguchi, Ryohei, Yukawa, Hiroshi, Odaka, Hidefumi, Hasegawa, Yoshinori, Baba, Yoshinobu, Hori, Masaru
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container_issue 6S2
container_start_page 6
container_title Japanese Journal of Applied Physics
container_volume 57
creator Kihara, Naoto
Kuboyama, Daiki
Onoshima, Daisuke
Ishikawa, Kenji
Tanaka, Hiromasa
Ozawa, Naoya
Hase, Tetsunari
Koguchi, Ryohei
Yukawa, Hiroshi
Odaka, Hidefumi
Hasegawa, Yoshinori
Baba, Yoshinobu
Hori, Masaru
description A fluoropolymer membrane filter with through-holes was fabricated by photolithographic patterning and the dry etching method. 380,000 highly packed through-holes, each with a diameter of 7 µm were able to cover a whole area with a diameter of 13 mm. Ethylene tetrafluoroethylene (ETFE) was used as the membrane, which was suitable for the fluorescence detection of rare cells such as circulating tumor cells (CTCs) in human blood. The device fabrication for the size based capture of rare cells in blood such as CTCs is realized in this study.
doi_str_mv 10.7567/JJAP.57.06JF03
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source IOP Publishing Journals; Institute of Physics (IOP) Journals - HEAL-Link
subjects Blood circulation
Ethylene tetrafluoroethylenes
Fluorescence
Fluoropolymers
Photolithography
title Low-autofluorescence fluoropolymer membrane filters for cell filtration
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