Human airway macrophages are metabolically reprogrammed by IFN-γ resulting in glycolysis-dependent functional plasticity

Airway macrophages (AM) are the predominant immune cell in the lung and play a crucial role in preventing infection, making them a target for host directed therapy. Macrophage effector functions are associated with cellular metabolism. A knowledge gap remains in understanding metabolic reprogramming...

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Veröffentlicht in:	eLife 2024-12, Vol.13
Hauptverfasser:	Cox, Donal J, Connolly, Sarah A, Ó Maoldomhnaigh, Cilian, Brugman, Aenea AI, Sandby Thomas, Olivia, Duffin, Emily, Gogan, Karl M, Ó Gallchobhair, Oisin, Murphy, Dearbhla M, O'Rourke, Sinead A, O'Connell, Finbarr, Nadarajan, Parthiban, Phelan, James J, Gleeson, Laura E, Basdeo, Sharee A, Keane, Joseph
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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