Neurons enhance blood–brain barrier function via upregulating claudin-5 and VE-cadherin expression due to glial cell line-derived neurotrophic factor secretion

Blood–brain barrier (BBB) prevents neurotoxins from entering central nervous system. We aimed to establish and characterize an in vitro triple co-culture BBB model consisting of brain endothelial cells hCMEC/D3, astrocytoma U251 cells, and neuroblastoma SH-SY5Y cells. Co-culture of SH-SY5Y and U251...

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Veröffentlicht in:	eLife 2024-10, Vol.13
Hauptverfasser:	Yang, Lu, Lin, Zijin, Mu, Ruijing, Wu, Wenhan, Zhi, Hao, Liu, Xiaodong, Yang, Hanyu, Liu, Li
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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