Divergent folding-mediated epistasis among unstable membrane protein variants

Many membrane proteins are prone to misfolding, which compromises their functional expression at the plasma membrane. This is particularly true for the mammalian gonadotropin-releasing hormone receptor GPCRs (GnRHR). We recently demonstrated that evolutionary GnRHR modifications appear to have coinc...

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Veröffentlicht in:	eLife 2024-07, Vol.12
Hauptverfasser:	Chamness, Laura M, Kuntz, Charles P, McKee, Andrew G, Penn, Wesley D, Hemmerich, Christopher M, Rusch, Douglas B, Woods, Hope, Dyotima, Meiler, Jens, Schlebach, Jonathan P
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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