Genetic code expansion, click chemistry, and light-activated PI3K reveal details of membrane protein trafficking downstream of receptor tyrosine kinases

Ligands such as insulin, epidermal growth factor, platelet-derived growth factor, and nerve growth factor (NGF) initiate signals at the cell membrane by binding to receptor tyrosine kinases (RTKs). Along with G-protein-coupled receptors, RTKs are the main platforms for transducing extracellular sign...

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Veröffentlicht in:	eLife 2024-08, Vol.12
Hauptverfasser:	Koh, Duk-Su, Stratiievska, Anastasiia, Jana, Subhashis, Otto, Shauna C, Swanson, Teresa M, Nhim, Anthony, Carlson, Sara, Raza, Marium, Naves, Ligia Araujo, Senning, Eric N, Mehl, Ryan A, Gordon, Sharona E
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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