Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

Partial reprogramming by cyclic short-term expression of Yamanaka factors holds promise for shifting cells to younger states and consequently delaying the onset of many diseases of aging. However, the delivery of transgenes and potential risk of teratoma formation present challenges for in vivo appl...

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Veröffentlicht in:	eLife 2024-03, Vol.12
Hauptverfasser:	Mitchell, Wayne, Goeminne, Ludger JE, Tyshkovskiy, Alexander, Zhang, Sirui, Chen, Julie Y, Paulo, Joao A, Pierce, Kerry A, Choy, Angelina H, Clish, Clary B, Gygi, Steven P, Gladyshev, Vadim N
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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