Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation

Van Gogh-like 2 (Vangl2), a core planar cell polarity component, plays an important role in polarized cellular and tissue morphology induction, growth development, and cancer. However, its role in regulating inflammatory responses remains elusive. Here, we report that Vangl2 is upregulated in patien...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	eLife 2024-09, Vol.12
Hauptverfasser:	Lu, Jiansen, Zhang, Jiahuan, Jiang, Huaji, Hu, Zhiqiang, Zhang, Yufen, He, Lian, Yang, Jianwu, Xie, Yingchao, Wu, Dan, Li, Hongyu, Zeng, Ke, Tan, Peng, Xiao, Qingyue, Song, Zijing, Pan, Chenglong, Bai, Xiaochun, Yu, Xiao
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!