Biosynthesis of Hibarimicins: III. Structures of New Hibarimicin-related Metabolites Produced by Blocked Mutants

Structures of metabolites produced by blocked mutants of Microbispora rosea subsp. hibaria TP-A0121, hibarimicin-producer, were determined by spectroscopic analysis. HMP-Y6 is the dimer of the west half of hibarimicin B, the aglycon of which is the genuine biosynthetic intermediate. HMP-P1 is the sh...

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Veröffentlicht in:	Journal of antibiotics 2002/01/25, Vol.55(1), pp.61-70
Hauptverfasser:	IGARASHI, YASUHIRO, KAJIURA, TAKAYUKI, FURUMAI, TAMOTSU, HORI, HIROSHI, HIGASHI, KAZUAKI, ISHIYAMA, TADAYUKI, URAMOTO, MASAKAZU, UEHARA, YOSHIMASA, OKI, TOSHIKAZU
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antineoplastic agents Applied microbiology Biological and medical sciences Chemotherapic agents Fermentation Fundamental and applied biological sciences. Psychology General aspects Magnetic Resonance Spectroscopy Medical sciences Microbiology Mutagenesis Pharmacology. Drug treatments Structure-Activity Relationship
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