NF00659A1, A2, A3, B1 and B2, Novel Antitumor Antibiotics Produced by Aspergillus sp. NF 00659: I. Taxonomy, Fermentation, Isolation and Biological Activities

Five novel cytotoxic antibiotics, NF00659A1 (1), A2(2), A3(3), B1(4) and B2(5) were discovered. They were isolated from a culture mycelium of Aspergillus sp. These compounds were proved to have 4, 5-seco-tricyclic diterpene α-pyrone structure by spectroscopic analyses. They showed potent antitumor a...

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Veröffentlicht in:	Journal of antibiotics 1997/04/25, Vol.50(4), pp.314-317
Hauptverfasser:	SUZUKI, KATSUHIRO, KUWAHARA, ATSUSHI, YOSHIDA, HIROSHI, FUJITA, SHINJI, NISHIKIORI, TAKAAKI, NAKAGAWA, TAIZO
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Animals Antibiotics, Antineoplastic - isolation & purification Antibiotics, Antineoplastic - therapeutic use Antibiotics, Antineoplastic - toxicity Colorectal Neoplasms - drug therapy Culex - drug effects Diterpenes - isolation & purification Diterpenes - therapeutic use Diterpenes - toxicity Female Fermentation Humans Insecticides - isolation & purification Insecticides - pharmacology Insecticides - toxicity Mice Microbial Sensitivity Tests Moths - drug effects Ovarian Neoplasms - drug therapy Pyrones - isolation & purification Pyrones - therapeutic use Pyrones - toxicity Tumor Cells, Cultured - drug effects
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