NF00659A1, A2, A3, B1 and B2, Novel Antitumor Antibiotics Produced by Aspergillus sp. NF 00659: I. Taxonomy, Fermentation, Isolation and Biological Activities
Five novel cytotoxic antibiotics, NF00659A1 (1), A2(2), A3(3), B1(4) and B2(5) were discovered. They were isolated from a culture mycelium of Aspergillus sp. These compounds were proved to have 4, 5-seco-tricyclic diterpene α-pyrone structure by spectroscopic analyses. They showed potent antitumor a...
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| Veröffentlicht in: | Journal of antibiotics 1997/04/25, Vol.50(4), pp.314-317 |
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| container_issue | 4 |
| container_start_page | 314 |
| container_title | Journal of antibiotics |
| container_volume | 50 |
| creator | SUZUKI, KATSUHIRO KUWAHARA, ATSUSHI YOSHIDA, HIROSHI FUJITA, SHINJI NISHIKIORI, TAKAAKI NAKAGAWA, TAIZO |
| description | Five novel cytotoxic antibiotics, NF00659A1 (1), A2(2), A3(3), B1(4) and B2(5) were discovered. They were isolated from a culture mycelium of Aspergillus sp. These compounds were proved to have 4, 5-seco-tricyclic diterpene α-pyrone structure by spectroscopic analyses. They showed potent antitumor activities against human ovarian carcinoma A2780 and human colorectal adenocarcinoma SW480 cells, but did not show any antimicrobial activities at 1, 000μg/ml against Gram-positive and Gram-negative bacteria, yeasts and fungi. |
| doi_str_mv | 10.7164/antibiotics.50.314 |
| format | Article |
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NF 00659: I. Taxonomy, Fermentation, Isolation and Biological Activities</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>Five novel cytotoxic antibiotics, NF00659A1 (1), A2(2), A3(3), B1(4) and B2(5) were discovered. They were isolated from a culture mycelium of Aspergillus sp. These compounds were proved to have 4, 5-seco-tricyclic diterpene α-pyrone structure by spectroscopic analyses. 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NF 00659</title><author>SUZUKI, KATSUHIRO ; KUWAHARA, ATSUSHI ; YOSHIDA, HIROSHI ; FUJITA, SHINJI ; NISHIKIORI, TAKAAKI ; NAKAGAWA, TAIZO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3914-60ef3f7d9b314147707ada7fb50460a5f3b40f499850b53b44b16189563c56683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adenocarcinoma - drug therapy</topic><topic>Animals</topic><topic>Antibiotics, Antineoplastic - isolation & purification</topic><topic>Antibiotics, Antineoplastic - therapeutic use</topic><topic>Antibiotics, Antineoplastic - toxicity</topic><topic>Colorectal Neoplasms - drug therapy</topic><topic>Culex - drug effects</topic><topic>Diterpenes - isolation & purification</topic><topic>Diterpenes - therapeutic use</topic><topic>Diterpenes - toxicity</topic><topic>Female</topic><topic>Fermentation</topic><topic>Humans</topic><topic>Insecticides - isolation & purification</topic><topic>Insecticides - pharmacology</topic><topic>Insecticides - toxicity</topic><topic>Mice</topic><topic>Microbial Sensitivity Tests</topic><topic>Moths - drug effects</topic><topic>Ovarian Neoplasms - drug therapy</topic><topic>Pyrones - isolation & purification</topic><topic>Pyrones - therapeutic use</topic><topic>Pyrones - toxicity</topic><topic>Tumor Cells, Cultured - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SUZUKI, KATSUHIRO</creatorcontrib><creatorcontrib>KUWAHARA, ATSUSHI</creatorcontrib><creatorcontrib>YOSHIDA, HIROSHI</creatorcontrib><creatorcontrib>FUJITA, SHINJI</creatorcontrib><creatorcontrib>NISHIKIORI, TAKAAKI</creatorcontrib><creatorcontrib>NAKAGAWA, TAIZO</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SUZUKI, KATSUHIRO</au><au>KUWAHARA, ATSUSHI</au><au>YOSHIDA, HIROSHI</au><au>FUJITA, SHINJI</au><au>NISHIKIORI, TAKAAKI</au><au>NAKAGAWA, TAIZO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NF00659A1, A2, A3, B1 and B2, Novel Antitumor Antibiotics Produced by Aspergillus sp. 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| ispartof | The Journal of Antibiotics, 1997/04/25, Vol.50(4), pp.314-317 |
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| language | eng |
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| source | J-STAGE Free; MEDLINE |
| subjects | Adenocarcinoma - drug therapy Animals Antibiotics, Antineoplastic - isolation & purification Antibiotics, Antineoplastic - therapeutic use Antibiotics, Antineoplastic - toxicity Colorectal Neoplasms - drug therapy Culex - drug effects Diterpenes - isolation & purification Diterpenes - therapeutic use Diterpenes - toxicity Female Fermentation Humans Insecticides - isolation & purification Insecticides - pharmacology Insecticides - toxicity Mice Microbial Sensitivity Tests Moths - drug effects Ovarian Neoplasms - drug therapy Pyrones - isolation & purification Pyrones - therapeutic use Pyrones - toxicity Tumor Cells, Cultured - drug effects |
| title | NF00659A1, A2, A3, B1 and B2, Novel Antitumor Antibiotics Produced by Aspergillus sp. NF 00659: I. Taxonomy, Fermentation, Isolation and Biological Activities |
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