PREPARATION OF NEW 7-HYDROXYGUANINE DERIVATIVES AND THEIR BIOLOGICAL ACTIVITIES

We prepared new 7-hydroxyguanine derivatives, 7-hydroxyguanosine 5'-monophosphate and N2-tetrahydropyranyl-7-hydroxyguanine, and compared biological activities of 7-hydroxyguanine derivatives including nucleosides acquired previously. 7-Hydroxyguanine and its nucleotide inhibited the focus form...

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Veröffentlicht in:	Journal of antibiotics 1990/04/25, Vol.43(4), pp.352-356
Hauptverfasser:	KITAHARA, MIKIO, SHINJYO, KATSUHIRO, FUKAE, MASAFUMI, HOSOE, KAZUNORI, SHIRAISHI, TADAYOSHI, ISHII, KIYOTO, WATANABE, KIYOSHI, KAWAHARADA, HAJIME
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Avian Sarcoma Viruses - drug effects Biological and medical sciences Cell Division - drug effects General aspects Guanine - analogs & derivatives Guanine - chemical synthesis Guanine - pharmacology Guanine - toxicity Guanine Nucleotides - chemical synthesis Guanosine Monophosphate - analogs & derivatives Guanosine Monophosphate - chemical synthesis Guanosine Monophosphate - pharmacology Guanosine Monophosphate - toxicity Humans Leukemia L1210 - drug therapy Male Medical sciences Mice Mice, Inbred ICR Molecular Structure Pharmacology. Drug treatments Pyrans - chemical synthesis Pyrans - pharmacology Pyrans - toxicity Tumor Cells, Cultured - drug effects
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Zusammenfassung:	We prepared new 7-hydroxyguanine derivatives, 7-hydroxyguanosine 5'-monophosphate and N2-tetrahydropyranyl-7-hydroxyguanine, and compared biological activities of 7-hydroxyguanine derivatives including nucleosides acquired previously. 7-Hydroxyguanine and its nucleotide inhibited the focus formation of Rous sarcoma virus. Antitumor activities of these derivatives against mouse leukemia L1210 were not so different from one another. Anti-proliferative activities of the derivatives on various human cell lines were significantly different from one another.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.43.352