ELEVATION OF GLUCOSAMINE 6-PHOSPHATE SYNTHETASE ACTIVITY IN BLEOMYCIN-INDUCED PULMONARY FIBROSIS IN HAMSTERS

The single intratracheal instillation of bleomycin sulfate (0.5mg (potency) per 100g body weight) in hamsters rapidly increased the activity of glucosamine 6-phosphate synthetase (EC 2.6.1.16) of the lung, a major regulatory enzyme for the synthesis of acidic glycosaminoglycan (AGAG). The activity i...

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Veröffentlicht in:Journal of antibiotics 1982, Vol.35(7), pp.882-885
Hauptverfasser: YOSHIDA, AKIRA, HIRAMATSU, MASAHIKO, HATAKEYAMA, KEIKO, MINAMI, NAOMI
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container_end_page 885
container_issue 7
container_start_page 882
container_title Journal of antibiotics
container_volume 35
creator YOSHIDA, AKIRA
HIRAMATSU, MASAHIKO
HATAKEYAMA, KEIKO
MINAMI, NAOMI
description The single intratracheal instillation of bleomycin sulfate (0.5mg (potency) per 100g body weight) in hamsters rapidly increased the activity of glucosamine 6-phosphate synthetase (EC 2.6.1.16) of the lung, a major regulatory enzyme for the synthesis of acidic glycosaminoglycan (AGAG). The activity increased as early as day 2, reached maximum level at day 10, then decreased and returned to the control level at day 45. The content of AGAG was also in creased by bleomycin treatment, but the increase of AGAG followed the elevation of the enzyme activity. These results suggest that the early elevation of glucosamine 6-phosphate synthetase activity is closely related to the accumulation of AGAG in the fibrosing lung caused by bleomycin.
doi_str_mv 10.7164/antibiotics.35.882
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The activity increased as early as day 2, reached maximum level at day 10, then decreased and returned to the control level at day 45. The content of AGAG was also in creased by bleomycin treatment, but the increase of AGAG followed the elevation of the enzyme activity. 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Antibiot.</addtitle><date>1982-01-01</date><risdate>1982</risdate><volume>35</volume><issue>7</issue><spage>882</spage><epage>885</epage><pages>882-885</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>The single intratracheal instillation of bleomycin sulfate (0.5mg (potency) per 100g body weight) in hamsters rapidly increased the activity of glucosamine 6-phosphate synthetase (EC 2.6.1.16) of the lung, a major regulatory enzyme for the synthesis of acidic glycosaminoglycan (AGAG). The activity increased as early as day 2, reached maximum level at day 10, then decreased and returned to the control level at day 45. The content of AGAG was also in creased by bleomycin treatment, but the increase of AGAG followed the elevation of the enzyme activity. 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subjects Aldose-Ketose Isomerases
Animals
Bleomycin - adverse effects
Carbohydrate Epimerases - metabolism
Cricetinae
Glycosaminoglycans - metabolism
Lung - enzymology
Male
Pulmonary Fibrosis - chemically induced
Transaminases - metabolism
title ELEVATION OF GLUCOSAMINE 6-PHOSPHATE SYNTHETASE ACTIVITY IN BLEOMYCIN-INDUCED PULMONARY FIBROSIS IN HAMSTERS
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