ELEVATION OF GLUCOSAMINE 6-PHOSPHATE SYNTHETASE ACTIVITY IN BLEOMYCIN-INDUCED PULMONARY FIBROSIS IN HAMSTERS
The single intratracheal instillation of bleomycin sulfate (0.5mg (potency) per 100g body weight) in hamsters rapidly increased the activity of glucosamine 6-phosphate synthetase (EC 2.6.1.16) of the lung, a major regulatory enzyme for the synthesis of acidic glycosaminoglycan (AGAG). The activity i...
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Veröffentlicht in: | Journal of antibiotics 1982, Vol.35(7), pp.882-885 |
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container_title | Journal of antibiotics |
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creator | YOSHIDA, AKIRA HIRAMATSU, MASAHIKO HATAKEYAMA, KEIKO MINAMI, NAOMI |
description | The single intratracheal instillation of bleomycin sulfate (0.5mg (potency) per 100g body weight) in hamsters rapidly increased the activity of glucosamine 6-phosphate synthetase (EC 2.6.1.16) of the lung, a major regulatory enzyme for the synthesis of acidic glycosaminoglycan (AGAG). The activity increased as early as day 2, reached maximum level at day 10, then decreased and returned to the control level at day 45. The content of AGAG was also in creased by bleomycin treatment, but the increase of AGAG followed the elevation of the enzyme activity. These results suggest that the early elevation of glucosamine 6-phosphate synthetase activity is closely related to the accumulation of AGAG in the fibrosing lung caused by bleomycin. |
doi_str_mv | 10.7164/antibiotics.35.882 |
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The activity increased as early as day 2, reached maximum level at day 10, then decreased and returned to the control level at day 45. The content of AGAG was also in creased by bleomycin treatment, but the increase of AGAG followed the elevation of the enzyme activity. These results suggest that the early elevation of glucosamine 6-phosphate synthetase activity is closely related to the accumulation of AGAG in the fibrosing lung caused by bleomycin.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.35.882</identifier><identifier>PMID: 6184359</identifier><language>eng</language><publisher>Japan: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Aldose-Ketose Isomerases ; Animals ; Bleomycin - adverse effects ; Carbohydrate Epimerases - metabolism ; Cricetinae ; Glycosaminoglycans - metabolism ; Lung - enzymology ; Male ; Pulmonary Fibrosis - chemically induced ; Transaminases - metabolism</subject><ispartof>The Journal of Antibiotics, 1982, Vol.35(7), pp.882-885</ispartof><rights>Japan Antibiotics Research Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c602t-8d53b05243d942b4c030c6f1341a29fe98fd4ee2f00aec546d5f2cba4eb51823</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6184359$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YOSHIDA, AKIRA</creatorcontrib><creatorcontrib>HIRAMATSU, MASAHIKO</creatorcontrib><creatorcontrib>HATAKEYAMA, KEIKO</creatorcontrib><creatorcontrib>MINAMI, NAOMI</creatorcontrib><title>ELEVATION OF GLUCOSAMINE 6-PHOSPHATE SYNTHETASE ACTIVITY IN BLEOMYCIN-INDUCED PULMONARY FIBROSIS IN HAMSTERS</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>The single intratracheal instillation of bleomycin sulfate (0.5mg (potency) per 100g body weight) in hamsters rapidly increased the activity of glucosamine 6-phosphate synthetase (EC 2.6.1.16) of the lung, a major regulatory enzyme for the synthesis of acidic glycosaminoglycan (AGAG). The activity increased as early as day 2, reached maximum level at day 10, then decreased and returned to the control level at day 45. The content of AGAG was also in creased by bleomycin treatment, but the increase of AGAG followed the elevation of the enzyme activity. These results suggest that the early elevation of glucosamine 6-phosphate synthetase activity is closely related to the accumulation of AGAG in the fibrosing lung caused by bleomycin.</description><subject>Aldose-Ketose Isomerases</subject><subject>Animals</subject><subject>Bleomycin - adverse effects</subject><subject>Carbohydrate Epimerases - metabolism</subject><subject>Cricetinae</subject><subject>Glycosaminoglycans - metabolism</subject><subject>Lung - enzymology</subject><subject>Male</subject><subject>Pulmonary Fibrosis - chemically induced</subject><subject>Transaminases - metabolism</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMtugkAYhSdNG2ttX6BJk3kB7NyAYYl0lEkRjIwmrMgAQ6vxFrCLvn2xGuPmP8l_zvkWB4BXjIYudti73h1XxWp_XJXtkNpDzskd6GPOsYWZ492DPkIEW90bPYKntl0jRF3q8h7oOZgzant9sBGRWPpKJjFMxnASLYIk9acyFtCxZmGSzkJfCZhmsQqF8lMB_UDJpVQZlDEcRSKZZoGMLRl_LALxAWeLaJrE_jyDYzmaJ6lMT7nQn6ZKzNNn8FDrTWteLjoAaixUEFpRMpGBH1mlg8jR4pVNC2QTRiuPkYKViKLSqTFlWBOvNh6vK2YMqRHSprSZU9k1KQvNTGFjTugAkDO2bPZt25g6PzSrrW5-c4zy03D5zXA5tXP-X3o7lw4_xdZU18plqc7_PPvr9qi_zNXXTUfZmFsk9hx-wrrn09GvqfJbN7nZ0T-hzX_2</recordid><startdate>19820101</startdate><enddate>19820101</enddate><creator>YOSHIDA, AKIRA</creator><creator>HIRAMATSU, MASAHIKO</creator><creator>HATAKEYAMA, KEIKO</creator><creator>MINAMI, NAOMI</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19820101</creationdate><title>ELEVATION OF GLUCOSAMINE 6-PHOSPHATE SYNTHETASE ACTIVITY IN BLEOMYCIN-INDUCED PULMONARY FIBROSIS IN HAMSTERS</title><author>YOSHIDA, AKIRA ; HIRAMATSU, MASAHIKO ; HATAKEYAMA, KEIKO ; MINAMI, NAOMI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c602t-8d53b05243d942b4c030c6f1341a29fe98fd4ee2f00aec546d5f2cba4eb51823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Aldose-Ketose Isomerases</topic><topic>Animals</topic><topic>Bleomycin - adverse effects</topic><topic>Carbohydrate Epimerases - metabolism</topic><topic>Cricetinae</topic><topic>Glycosaminoglycans - metabolism</topic><topic>Lung - enzymology</topic><topic>Male</topic><topic>Pulmonary Fibrosis - chemically induced</topic><topic>Transaminases - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YOSHIDA, AKIRA</creatorcontrib><creatorcontrib>HIRAMATSU, MASAHIKO</creatorcontrib><creatorcontrib>HATAKEYAMA, KEIKO</creatorcontrib><creatorcontrib>MINAMI, NAOMI</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YOSHIDA, AKIRA</au><au>HIRAMATSU, MASAHIKO</au><au>HATAKEYAMA, KEIKO</au><au>MINAMI, NAOMI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ELEVATION OF GLUCOSAMINE 6-PHOSPHATE SYNTHETASE ACTIVITY IN BLEOMYCIN-INDUCED PULMONARY FIBROSIS IN HAMSTERS</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1982-01-01</date><risdate>1982</risdate><volume>35</volume><issue>7</issue><spage>882</spage><epage>885</epage><pages>882-885</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>The single intratracheal instillation of bleomycin sulfate (0.5mg (potency) per 100g body weight) in hamsters rapidly increased the activity of glucosamine 6-phosphate synthetase (EC 2.6.1.16) of the lung, a major regulatory enzyme for the synthesis of acidic glycosaminoglycan (AGAG). The activity increased as early as day 2, reached maximum level at day 10, then decreased and returned to the control level at day 45. The content of AGAG was also in creased by bleomycin treatment, but the increase of AGAG followed the elevation of the enzyme activity. These results suggest that the early elevation of glucosamine 6-phosphate synthetase activity is closely related to the accumulation of AGAG in the fibrosing lung caused by bleomycin.</abstract><cop>Japan</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>6184359</pmid><doi>10.7164/antibiotics.35.882</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
subjects | Aldose-Ketose Isomerases Animals Bleomycin - adverse effects Carbohydrate Epimerases - metabolism Cricetinae Glycosaminoglycans - metabolism Lung - enzymology Male Pulmonary Fibrosis - chemically induced Transaminases - metabolism |
title | ELEVATION OF GLUCOSAMINE 6-PHOSPHATE SYNTHETASE ACTIVITY IN BLEOMYCIN-INDUCED PULMONARY FIBROSIS IN HAMSTERS |
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