SORBISTIN, A NEW AMINOGLYCOSIDE ANTIBIOTIC COMPLEX OF BACTERIAL ORIGIN: I. PRODUCTION, ISOLATION AND PROPERTIES
A strain of a new Pseudomonas species produced the aminoglycoside antibiotic complex, sorbistin, which was separated by ion-exchange chromatography into three bio-active components A1, A2 and B, and two bio-inactive components C and D. Sorbistins A1, A2 and B showed moderate intrinsic activity again...
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| Veröffentlicht in: | Journal of antibiotics 1976, Vol.29(11), pp.1137-1146 |
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| container_end_page | 1146 |
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| container_issue | 11 |
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| container_title | Journal of antibiotics |
| container_volume | 29 |
| creator | TSUKIURA, HIROSHI HANADA, MINORU SAITO, KYOICHIRO FUJISAWA, KEI-ICHI MIYAKI, TAKEO KOSHIYAMA, HIDEO KAWAGUCHI, HIROSHI |
| description | A strain of a new Pseudomonas species produced the aminoglycoside antibiotic complex, sorbistin, which was separated by ion-exchange chromatography into three bio-active components A1, A2 and B, and two bio-inactive components C and D. Sorbistins A1, A2 and B showed moderate intrinsic activity against a wide range of bacterial species and inhibited most of the aminoglycoside-resistant organisms. Sorbistin A1 exhibited the highest activity among the three bio-active components. Sorbistins showed low order of acute toxicity in mice. |
| doi_str_mv | 10.7164/antibiotics.29.1137 |
| format | Article |
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Sorbistins showed low order of acute toxicity in mice.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.29.1137</identifier><identifier>PMID: 993100</identifier><language>eng</language><publisher>Japan: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Aminoglycosides - analysis ; Aminoglycosides - biosynthesis ; Aminoglycosides - pharmacology ; Animals ; Anti-Bacterial Agents - analysis ; Anti-Bacterial Agents - biosynthesis ; Anti-Bacterial Agents - pharmacology ; Bacteria - drug effects ; Bacterial Infections - drug therapy ; Chemical Phenomena ; Chemistry ; Fermentation ; Lethal Dose 50 ; Mice ; Pseudomonas - metabolism</subject><ispartof>The Journal of Antibiotics, 1976, Vol.29(11), pp.1137-1146</ispartof><rights>Japan Antibiotics Research Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3967-18eefb9f0da2bc5ced27be1b8029d9b8c2f26041db50a9dff2c78bfde3243f6a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,4025,27928,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/993100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TSUKIURA, HIROSHI</creatorcontrib><creatorcontrib>HANADA, MINORU</creatorcontrib><creatorcontrib>SAITO, KYOICHIRO</creatorcontrib><creatorcontrib>FUJISAWA, KEI-ICHI</creatorcontrib><creatorcontrib>MIYAKI, TAKEO</creatorcontrib><creatorcontrib>KOSHIYAMA, HIDEO</creatorcontrib><creatorcontrib>KAWAGUCHI, HIROSHI</creatorcontrib><title>SORBISTIN, A NEW AMINOGLYCOSIDE ANTIBIOTIC COMPLEX OF BACTERIAL ORIGIN: I. PRODUCTION, ISOLATION AND PROPERTIES</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>A strain of a new Pseudomonas species produced the aminoglycoside antibiotic complex, sorbistin, which was separated by ion-exchange chromatography into three bio-active components A1, A2 and B, and two bio-inactive components C and D. Sorbistins A1, A2 and B showed moderate intrinsic activity against a wide range of bacterial species and inhibited most of the aminoglycoside-resistant organisms. Sorbistin A1 exhibited the highest activity among the three bio-active components. Sorbistins showed low order of acute toxicity in mice.</description><subject>Aminoglycosides - analysis</subject><subject>Aminoglycosides - biosynthesis</subject><subject>Aminoglycosides - pharmacology</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - analysis</subject><subject>Anti-Bacterial Agents - biosynthesis</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacteria - drug effects</subject><subject>Bacterial Infections - drug therapy</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>Fermentation</subject><subject>Lethal Dose 50</subject><subject>Mice</subject><subject>Pseudomonas - metabolism</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMtSwjAYhTOON0SfQBd5AIu5lDZZllowM6VxoI666iRpomUQmAYXvr0wZRg2_78453yLD4B7jAYxjsIntdo2ullvG-MHhA8wpvEZ6GHGcIDDiJ-DHkIEB4wRdA1uvF8gRGMasytwyTnFCPXAeC5nIzEvRfEIE1hk7zCZikJO8s9UzsVzBpOiFCMhS5HCVE5f8-wDyjEcJWmZzUSSQzkTE1Hcggunlt7eHX4fvI2zMn0JcjkRaZIHhvIoDjCz1mnuUK2INkNjaxJrizVDhNdcM0MciVCIaz1EitfOERMz7WpLSUhdpGgf0I5r2rX3rXXVpm1-VPtXYVTtnVQnTirCq72T3eqhW21-9Y-tj5tOwi4uunjht-rLHmPV7ihLe4rEPGId9nD3_GPRfKu2siv6D63xdsU</recordid><startdate>1976</startdate><enddate>1976</enddate><creator>TSUKIURA, HIROSHI</creator><creator>HANADA, MINORU</creator><creator>SAITO, KYOICHIRO</creator><creator>FUJISAWA, KEI-ICHI</creator><creator>MIYAKI, TAKEO</creator><creator>KOSHIYAMA, HIDEO</creator><creator>KAWAGUCHI, HIROSHI</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1976</creationdate><title>SORBISTIN, A NEW AMINOGLYCOSIDE ANTIBIOTIC COMPLEX OF BACTERIAL ORIGIN</title><author>TSUKIURA, HIROSHI ; HANADA, MINORU ; SAITO, KYOICHIRO ; FUJISAWA, KEI-ICHI ; MIYAKI, TAKEO ; KOSHIYAMA, HIDEO ; KAWAGUCHI, HIROSHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3967-18eefb9f0da2bc5ced27be1b8029d9b8c2f26041db50a9dff2c78bfde3243f6a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Aminoglycosides - analysis</topic><topic>Aminoglycosides - biosynthesis</topic><topic>Aminoglycosides - pharmacology</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - analysis</topic><topic>Anti-Bacterial Agents - biosynthesis</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Bacteria - drug effects</topic><topic>Bacterial Infections - drug therapy</topic><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>Fermentation</topic><topic>Lethal Dose 50</topic><topic>Mice</topic><topic>Pseudomonas - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TSUKIURA, HIROSHI</creatorcontrib><creatorcontrib>HANADA, MINORU</creatorcontrib><creatorcontrib>SAITO, KYOICHIRO</creatorcontrib><creatorcontrib>FUJISAWA, KEI-ICHI</creatorcontrib><creatorcontrib>MIYAKI, TAKEO</creatorcontrib><creatorcontrib>KOSHIYAMA, HIDEO</creatorcontrib><creatorcontrib>KAWAGUCHI, HIROSHI</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TSUKIURA, HIROSHI</au><au>HANADA, MINORU</au><au>SAITO, KYOICHIRO</au><au>FUJISAWA, KEI-ICHI</au><au>MIYAKI, TAKEO</au><au>KOSHIYAMA, HIDEO</au><au>KAWAGUCHI, HIROSHI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SORBISTIN, A NEW AMINOGLYCOSIDE ANTIBIOTIC COMPLEX OF BACTERIAL ORIGIN: I. PRODUCTION, ISOLATION AND PROPERTIES</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1976</date><risdate>1976</risdate><volume>29</volume><issue>11</issue><spage>1137</spage><epage>1146</epage><pages>1137-1146</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>A strain of a new Pseudomonas species produced the aminoglycoside antibiotic complex, sorbistin, which was separated by ion-exchange chromatography into three bio-active components A1, A2 and B, and two bio-inactive components C and D. Sorbistins A1, A2 and B showed moderate intrinsic activity against a wide range of bacterial species and inhibited most of the aminoglycoside-resistant organisms. Sorbistin A1 exhibited the highest activity among the three bio-active components. Sorbistins showed low order of acute toxicity in mice.</abstract><cop>Japan</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>993100</pmid><doi>10.7164/antibiotics.29.1137</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1976, Vol.29(11), pp.1137-1146 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_crossref_primary_10_7164_antibiotics_29_1137 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Aminoglycosides - analysis Aminoglycosides - biosynthesis Aminoglycosides - pharmacology Animals Anti-Bacterial Agents - analysis Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - pharmacology Bacteria - drug effects Bacterial Infections - drug therapy Chemical Phenomena Chemistry Fermentation Lethal Dose 50 Mice Pseudomonas - metabolism |
| title | SORBISTIN, A NEW AMINOGLYCOSIDE ANTIBIOTIC COMPLEX OF BACTERIAL ORIGIN: I. PRODUCTION, ISOLATION AND PROPERTIES |
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