SORBISTIN, A NEW AMINOGLYCOSIDE ANTIBIOTIC COMPLEX OF BACTERIAL ORIGIN: I. PRODUCTION, ISOLATION AND PROPERTIES

SORBISTIN, A NEW AMINOGLYCOSIDE ANTIBIOTIC COMPLEX OF BACTERIAL ORIGIN: I. PRODUCTION, ISOLATION AND PROPERTIES

A strain of a new Pseudomonas species produced the aminoglycoside antibiotic complex, sorbistin, which was separated by ion-exchange chromatography into three bio-active components A1, A2 and B, and two bio-inactive components C and D. Sorbistins A1, A2 and B showed moderate intrinsic activity again...

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Veröffentlicht in:Journal of antibiotics 1976, Vol.29(11), pp.1137-1146
Hauptverfasser: TSUKIURA, HIROSHI, HANADA, MINORU, SAITO, KYOICHIRO, FUJISAWA, KEI-ICHI, MIYAKI, TAKEO, KOSHIYAMA, HIDEO, KAWAGUCHI, HIROSHI
Format: Artikel
Sprache:eng
Schlagworte:
Aminoglycosides - analysis
Aminoglycosides - biosynthesis
Aminoglycosides - pharmacology
Animals
Anti-Bacterial Agents - analysis
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - pharmacology
Bacteria - drug effects
Bacterial Infections - drug therapy
Chemical Phenomena
Chemistry
Fermentation
Lethal Dose 50
Mice
Pseudomonas - metabolism
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Zusammenfassung:A strain of a new Pseudomonas species produced the aminoglycoside antibiotic complex, sorbistin, which was separated by ion-exchange chromatography into three bio-active components A1, A2 and B, and two bio-inactive components C and D. Sorbistins A1, A2 and B showed moderate intrinsic activity against a wide range of bacterial species and inhibited most of the aminoglycoside-resistant organisms. Sorbistin A1 exhibited the highest activity among the three bio-active components. Sorbistins showed low order of acute toxicity in mice.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.29.1137