Immunization with the Gly 1127 -Cys 1140 amino acid sequence of the LRP1 receptor reduces atherosclerosis in rabbits. Molecular, immunohistochemical and nuclear imaging studies

: The LRP1 (CR9) domain and, in particular, the sequence Gly -Cys (P3) plays a critical role in the binding and internalization of aggregated LDL (agLDL). We aimed to evaluate whether immunization with P3 reduces high-fat diet (HFD)-induced atherosclerosis. : Female New Zealand White (NZW) rabbits w...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Theranostics 2020, Vol.10 (7), p.3263-3280
Hauptverfasser:	Bornachea, Olga, Benitez-Amaro, Aleyda, Vea, Angela, Nasarre, Laura, de Gonzalo-Calvo, David, Escola-Gil, Juan Carlos, Cedo, Lidia, Iborra, Antoni, Martínez-Martínez, Laura, Juarez, Candido, Camara, Juan Antonio, Espinet, Carina, Borrell-Pages, Maria, Badimon, Lina, Castell, Joan, Llorente-Cortés, Vicenta
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibody Specificity Aorta - cytology Aorta - diagnostic imaging Atherosclerosis - blood Atherosclerosis - diagnostic imaging Atherosclerosis - immunology Atherosclerosis - prevention & control Cells, Cultured Cholesterol Esters - metabolism Coronary Vessels - cytology Diet, High-Fat Female Humans Immunization Lipids - blood Lipoproteins - blood Low Density Lipoprotein Receptor-Related Protein-1 - chemistry Low Density Lipoprotein Receptor-Related Protein-1 - immunology Macrophages - drug effects Myocytes, Smooth Muscle - drug effects Peptide Fragments - immunology Positron Emission Tomography Computed Tomography Protein Domains Rabbits Random Allocation Ultrasonography, Doppler Vascular Resistance
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!