Squamous Cell Carcinoma of the Oral Floor after Allogenic Bone Marrow Transplantation: Report of a Case

We report a case of squamous cell carcinoma originating in the oral floor of a 53-year-old female patient after allogeneic bone marrow transplantation for chronic myeloblastic leukemia. The patient had been treated with immunosuppressants for chronic graft-versus-host disease. A residual lichenoid lesion of oral floor had transformed to squamous cell carcinoma during 6 years. It is emphasized that chronic graft-versus-host disease after bone marrow transplantation is strongly linked with an excess risk of squamous cell carcinoma of the oral cavity. Careful long-term follow-up of oral lesions after bone marrow transplantation is essential in order to detect second tumors at early stage.