Long-term graft function in a randomized clinical trial comparing laparoscopic versus open donor nephrectomy
To evaluate and compare the long-term graft and survival rates in kidney transplant recipients who had undergone laparoscopic donor nephrectomy versus those who underwent open donor nephrectomy. Our study was done with 100 cases of laparoscopic donor nephrectomy and 100 cases of open donor nephrecto...
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| Veröffentlicht in: | Experimental and clinical transplantation 2012-10, Vol.10 (5), p.428-432 |
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| container_title | Experimental and clinical transplantation |
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| creator | Simforoosh, Nasser Basiri, Abbas Shakhssalim, Nasser Gooran, Shahram Tabibi, Ali Khoshdel, Ali Ziaee, Seyed Amir Mohsen |
| description | To evaluate and compare the long-term graft and survival rates in kidney transplant recipients who had undergone laparoscopic donor nephrectomy versus those who underwent open donor nephrectomy.
Our study was done with 100 cases of laparoscopic donor nephrectomy and 100 cases of open donor nephrectomy, performed between July 2001 and September 2003. Mean follow-up of recipients in this study was 6.6 ± 2.4 years (range, 1-9.3 y). This study has a longer follow-up than previous randomized clinical trials. We compared patient and graft survival in recipients of laparoscopic donor nephrectomy versus those who had open donor nephrectomy.
Mean duration of kidney warm ischemia time was 8.7 ± 2.7 minutes for laparoscopic donor nephrectomy and 1.8 ± 0.92 minutes for open donor nephrectomy. There were no significant differences in 5-year graft survival between the laparoscopic donor nephrectomy and open donor nephrectomy groups (89.5% vs 84.3%; P = .96). There were no differences in delayed graft function between the laparoscopic donor nephrectomy and open donor nephrectomy groups (8 and 11 patients; P = .135). There was a significant difference in 5-year graft survival between recipients with a history of delayed graft function and those without delayed graft function (63.2% vs 89.7%; P = .04). Despite a longer warm ischemia time in laparoscopic donor nephrectomy group (8.69 vs 1.87 min; P = .0001), warm ischemia time had no effect on graft outcome in long-term follow-up.
Although earlier experiences with laparoscopic donor nephrectomies were associated with concerns about long-term effects of laparoscopic donation on the graft function in the recipient, our long-term results confirm that laparoscopic donor nephrectomy provides similar graft outcome to open donor nephrectomy. |
| doi_str_mv | 10.6002/ect.2012.0010 |
| format | Article |
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Our study was done with 100 cases of laparoscopic donor nephrectomy and 100 cases of open donor nephrectomy, performed between July 2001 and September 2003. Mean follow-up of recipients in this study was 6.6 ± 2.4 years (range, 1-9.3 y). This study has a longer follow-up than previous randomized clinical trials. We compared patient and graft survival in recipients of laparoscopic donor nephrectomy versus those who had open donor nephrectomy.
Mean duration of kidney warm ischemia time was 8.7 ± 2.7 minutes for laparoscopic donor nephrectomy and 1.8 ± 0.92 minutes for open donor nephrectomy. There were no significant differences in 5-year graft survival between the laparoscopic donor nephrectomy and open donor nephrectomy groups (89.5% vs 84.3%; P = .96). There were no differences in delayed graft function between the laparoscopic donor nephrectomy and open donor nephrectomy groups (8 and 11 patients; P = .135). There was a significant difference in 5-year graft survival between recipients with a history of delayed graft function and those without delayed graft function (63.2% vs 89.7%; P = .04). Despite a longer warm ischemia time in laparoscopic donor nephrectomy group (8.69 vs 1.87 min; P = .0001), warm ischemia time had no effect on graft outcome in long-term follow-up.
Although earlier experiences with laparoscopic donor nephrectomies were associated with concerns about long-term effects of laparoscopic donation on the graft function in the recipient, our long-term results confirm that laparoscopic donor nephrectomy provides similar graft outcome to open donor nephrectomy.</description><identifier>ISSN: 1304-0855</identifier><identifier>EISSN: 2146-8427</identifier><identifier>DOI: 10.6002/ect.2012.0010</identifier><identifier>PMID: 23031082</identifier><language>eng</language><publisher>Turkey</publisher><subject>Adult ; Delayed Graft Function - mortality ; Female ; Follow-Up Studies ; Graft Survival ; Humans ; Kidney - physiology ; Kidney Transplantation - methods ; Kidney Transplantation - mortality ; Laparoscopy - methods ; Laparoscopy - mortality ; Male ; Middle Aged ; Nephrectomy - methods ; Nephrectomy - mortality ; Primary Graft Dysfunction - mortality ; Prospective Studies ; Treatment Outcome ; Young Adult</subject><ispartof>Experimental and clinical transplantation, 2012-10, Vol.10 (5), p.428-432</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-37e8f82592cad9f3ab6036fb4d2755d5e5787f458171827ca7ae37e45d5d58003</citedby><cites>FETCH-LOGICAL-c359t-37e8f82592cad9f3ab6036fb4d2755d5e5787f458171827ca7ae37e45d5d58003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23031082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Simforoosh, Nasser</creatorcontrib><creatorcontrib>Basiri, Abbas</creatorcontrib><creatorcontrib>Shakhssalim, Nasser</creatorcontrib><creatorcontrib>Gooran, Shahram</creatorcontrib><creatorcontrib>Tabibi, Ali</creatorcontrib><creatorcontrib>Khoshdel, Ali</creatorcontrib><creatorcontrib>Ziaee, Seyed Amir Mohsen</creatorcontrib><title>Long-term graft function in a randomized clinical trial comparing laparoscopic versus open donor nephrectomy</title><title>Experimental and clinical transplantation</title><addtitle>Exp Clin Transplant</addtitle><description>To evaluate and compare the long-term graft and survival rates in kidney transplant recipients who had undergone laparoscopic donor nephrectomy versus those who underwent open donor nephrectomy.
Our study was done with 100 cases of laparoscopic donor nephrectomy and 100 cases of open donor nephrectomy, performed between July 2001 and September 2003. Mean follow-up of recipients in this study was 6.6 ± 2.4 years (range, 1-9.3 y). This study has a longer follow-up than previous randomized clinical trials. We compared patient and graft survival in recipients of laparoscopic donor nephrectomy versus those who had open donor nephrectomy.
Mean duration of kidney warm ischemia time was 8.7 ± 2.7 minutes for laparoscopic donor nephrectomy and 1.8 ± 0.92 minutes for open donor nephrectomy. There were no significant differences in 5-year graft survival between the laparoscopic donor nephrectomy and open donor nephrectomy groups (89.5% vs 84.3%; P = .96). There were no differences in delayed graft function between the laparoscopic donor nephrectomy and open donor nephrectomy groups (8 and 11 patients; P = .135). There was a significant difference in 5-year graft survival between recipients with a history of delayed graft function and those without delayed graft function (63.2% vs 89.7%; P = .04). Despite a longer warm ischemia time in laparoscopic donor nephrectomy group (8.69 vs 1.87 min; P = .0001), warm ischemia time had no effect on graft outcome in long-term follow-up.
Although earlier experiences with laparoscopic donor nephrectomies were associated with concerns about long-term effects of laparoscopic donation on the graft function in the recipient, our long-term results confirm that laparoscopic donor nephrectomy provides similar graft outcome to open donor nephrectomy.</description><subject>Adult</subject><subject>Delayed Graft Function - mortality</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Graft Survival</subject><subject>Humans</subject><subject>Kidney - physiology</subject><subject>Kidney Transplantation - methods</subject><subject>Kidney Transplantation - mortality</subject><subject>Laparoscopy - methods</subject><subject>Laparoscopy - mortality</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nephrectomy - methods</subject><subject>Nephrectomy - mortality</subject><subject>Primary Graft Dysfunction - mortality</subject><subject>Prospective Studies</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>1304-0855</issn><issn>2146-8427</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LAzEQhoMottQevUr-wNbJ1yY9SvELFrzoecnmowZ2kyW7FeqvN6XqZWZgnhleHoRuCWxqAHrvzLyhQOgGgMAFWlLC60pxKi_RkjDgFSghFmg9TaEDzqWkvFbXaEEZMAKKLlHfpLivZpcHvM_az9gfoplDijhErHHW0aYhfDuLTR9iMLrHcw6lmjSMOoe4x70uQ5pMGoPBXy5Phwmn0UVsU0wZRzd-5hI0DccbdOV1P7n1b1-hj6fH991L1bw9v-4emsowsZ0rJp3yiootNdpuPdNdDaz2HbdUCmGFE1JJz4UikigqjZbalRteVlYoALZC1fmvKbmm7Hw75jDofGwJtCdxbcnTnsS1J3GFvzvz46EbnP2n_zSxH-YMavI</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Simforoosh, Nasser</creator><creator>Basiri, Abbas</creator><creator>Shakhssalim, Nasser</creator><creator>Gooran, Shahram</creator><creator>Tabibi, Ali</creator><creator>Khoshdel, Ali</creator><creator>Ziaee, Seyed Amir Mohsen</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20121001</creationdate><title>Long-term graft function in a randomized clinical trial comparing laparoscopic versus open donor nephrectomy</title><author>Simforoosh, Nasser ; Basiri, Abbas ; Shakhssalim, Nasser ; Gooran, Shahram ; Tabibi, Ali ; Khoshdel, Ali ; Ziaee, Seyed Amir Mohsen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-37e8f82592cad9f3ab6036fb4d2755d5e5787f458171827ca7ae37e45d5d58003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Delayed Graft Function - mortality</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Graft Survival</topic><topic>Humans</topic><topic>Kidney - physiology</topic><topic>Kidney Transplantation - methods</topic><topic>Kidney Transplantation - mortality</topic><topic>Laparoscopy - methods</topic><topic>Laparoscopy - mortality</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nephrectomy - methods</topic><topic>Nephrectomy - mortality</topic><topic>Primary Graft Dysfunction - mortality</topic><topic>Prospective Studies</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Simforoosh, Nasser</creatorcontrib><creatorcontrib>Basiri, Abbas</creatorcontrib><creatorcontrib>Shakhssalim, Nasser</creatorcontrib><creatorcontrib>Gooran, Shahram</creatorcontrib><creatorcontrib>Tabibi, Ali</creatorcontrib><creatorcontrib>Khoshdel, Ali</creatorcontrib><creatorcontrib>Ziaee, Seyed Amir Mohsen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Experimental and clinical transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Simforoosh, Nasser</au><au>Basiri, Abbas</au><au>Shakhssalim, Nasser</au><au>Gooran, Shahram</au><au>Tabibi, Ali</au><au>Khoshdel, Ali</au><au>Ziaee, Seyed Amir Mohsen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term graft function in a randomized clinical trial comparing laparoscopic versus open donor nephrectomy</atitle><jtitle>Experimental and clinical transplantation</jtitle><addtitle>Exp Clin Transplant</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>10</volume><issue>5</issue><spage>428</spage><epage>432</epage><pages>428-432</pages><issn>1304-0855</issn><eissn>2146-8427</eissn><abstract>To evaluate and compare the long-term graft and survival rates in kidney transplant recipients who had undergone laparoscopic donor nephrectomy versus those who underwent open donor nephrectomy.
Our study was done with 100 cases of laparoscopic donor nephrectomy and 100 cases of open donor nephrectomy, performed between July 2001 and September 2003. Mean follow-up of recipients in this study was 6.6 ± 2.4 years (range, 1-9.3 y). This study has a longer follow-up than previous randomized clinical trials. We compared patient and graft survival in recipients of laparoscopic donor nephrectomy versus those who had open donor nephrectomy.
Mean duration of kidney warm ischemia time was 8.7 ± 2.7 minutes for laparoscopic donor nephrectomy and 1.8 ± 0.92 minutes for open donor nephrectomy. There were no significant differences in 5-year graft survival between the laparoscopic donor nephrectomy and open donor nephrectomy groups (89.5% vs 84.3%; P = .96). There were no differences in delayed graft function between the laparoscopic donor nephrectomy and open donor nephrectomy groups (8 and 11 patients; P = .135). There was a significant difference in 5-year graft survival between recipients with a history of delayed graft function and those without delayed graft function (63.2% vs 89.7%; P = .04). Despite a longer warm ischemia time in laparoscopic donor nephrectomy group (8.69 vs 1.87 min; P = .0001), warm ischemia time had no effect on graft outcome in long-term follow-up.
Although earlier experiences with laparoscopic donor nephrectomies were associated with concerns about long-term effects of laparoscopic donation on the graft function in the recipient, our long-term results confirm that laparoscopic donor nephrectomy provides similar graft outcome to open donor nephrectomy.</abstract><cop>Turkey</cop><pmid>23031082</pmid><doi>10.6002/ect.2012.0010</doi><tpages>5</tpages></addata></record> |
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| ispartof | Experimental and clinical transplantation, 2012-10, Vol.10 (5), p.428-432 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Delayed Graft Function - mortality Female Follow-Up Studies Graft Survival Humans Kidney - physiology Kidney Transplantation - methods Kidney Transplantation - mortality Laparoscopy - methods Laparoscopy - mortality Male Middle Aged Nephrectomy - methods Nephrectomy - mortality Primary Graft Dysfunction - mortality Prospective Studies Treatment Outcome Young Adult |
| title | Long-term graft function in a randomized clinical trial comparing laparoscopic versus open donor nephrectomy |
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