Evaluation of human thyroid receptor-agonist activity in 796 chemical compounds using a yeast two-hybrid assay with Saccharomyces cerevisiae Y190

The human thyroid receptor (hTR)-agonist activities of 796 compounds were evaluated using a yeast two-hybrid assay in this study. A total of 17 compounds exhibited agonist activity at tenfold the effective concentration (EC×10) [0.0083–7,500 nM]. Additionally, TRIAC, TETRAC, and GC-1, which exhibite...

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Veröffentlicht in:	Environmental Monitoring and Contaminants Research 2022, Vol.2, pp.54-59
Hauptverfasser:	OMAGARI, Ryo, YAGISHITA, Mayuko, YAMASAKI, Miho, KAMATA, Ryo, TERASAKI, Masanori, SHIRAISHI, Fujio, KUBO, Takuya, NAKAJIMA, Daisuke
Format:	Artikel
Sprache:	eng
Schlagworte:	agonist activity EDSP21 human thyroid receptor thyroid hormones yeast two-hybrid assay
Online-Zugang:	Volltext
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