SYNDROME OF INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION AS A SIDE EFFECT OF CHEMOTHERAPY FOR URACHAL CARCINOMA: A CASE REPORT
A 54-year-old woman was admitted to our hospital complaining of gross hematuria and difficulty urinating. Cystoscopy revealed a tumor 4 cm in size with calcification on top of the bladder. After diagnosis of urachal carcinoma by transurethral resection of the bladder, partial cystectomy with en bloc...
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| Veröffentlicht in: | Nihon Hinyokika Gakkai zasshi. The japanese journal of urology 2021/04/20, Vol.112(2), pp.100-104 |
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| container_title | Nihon Hinyokika Gakkai zasshi. The japanese journal of urology |
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| creator | Maeda, Koki Mori, Yuri Nakamura, Masatoshi Harada, Yoshimasa Kodama, Kenichi |
| description | A 54-year-old woman was admitted to our hospital complaining of gross hematuria and difficulty urinating. Cystoscopy revealed a tumor 4 cm in size with calcification on top of the bladder. After diagnosis of urachal carcinoma by transurethral resection of the bladder, partial cystectomy with en bloc resection of the median umbilical ligament and pelvic lymphadenectomy was performed. Pathological diagnosis confirmed urachal carcinoma, pT3b, ly1, v0, pN1, RM0. TS-1 and cisplatin chemotherapy (TS-1 at 100 mg/day on days 1-21, CDDP at 60 mg/m2 on day 8) was administered. On day 13, the patient was admitted because of consciousness disorder (Glasgow Coma Scale E2V1M4). Hyponatremia (Na 109 mEq/l) and renal excretion of sodium were present and the patient was diagnosed with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) induced by chemotherapy. Serum sodium level and her consciousness level gradually improved after administration of 3% saline. SIADH caused by chemotherapy containing cisplatin is a relatively rare, but potentially serious adverse effect that requires close attention. |
| doi_str_mv | 10.5980/jpnjurol.112.100 |
| format | Article |
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Cystoscopy revealed a tumor 4 cm in size with calcification on top of the bladder. After diagnosis of urachal carcinoma by transurethral resection of the bladder, partial cystectomy with en bloc resection of the median umbilical ligament and pelvic lymphadenectomy was performed. Pathological diagnosis confirmed urachal carcinoma, pT3b, ly1, v0, pN1, RM0. TS-1 and cisplatin chemotherapy (TS-1 at 100 mg/day on days 1-21, CDDP at 60 mg/m2 on day 8) was administered. On day 13, the patient was admitted because of consciousness disorder (Glasgow Coma Scale E2V1M4). Hyponatremia (Na 109 mEq/l) and renal excretion of sodium were present and the patient was diagnosed with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) induced by chemotherapy. Serum sodium level and her consciousness level gradually improved after administration of 3% saline. SIADH caused by chemotherapy containing cisplatin is a relatively rare, but potentially serious adverse effect that requires close attention.</description><identifier>ISSN: 0021-5287</identifier><identifier>EISSN: 1884-7110</identifier><identifier>DOI: 10.5980/jpnjurol.112.100</identifier><identifier>PMID: 35444077</identifier><language>eng ; jpn</language><publisher>Japan: THE JAPANESE UROLOGICAL ASSOCIATION</publisher><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; chemotherapy ; Cisplatin - adverse effects ; Female ; Humans ; hyponatremia ; Inappropriate ADH Syndrome - chemically induced ; Inappropriate ADH Syndrome - diagnosis ; Middle Aged ; Research Report ; Sodium - adverse effects ; syndrome of inappropriate antidiuretic hormone secretion ; Urinary Bladder Neoplasms ; Vasopressins - adverse effects</subject><ispartof>The Japanese Journal of Urology, 2021/04/20, Vol.112(2), pp.100-104</ispartof><rights>2021 Japanese Urological Association</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2470-fccbe081a2671f98099315a9c214836fb4f4596f1742154a756c03f6b3b2626c3</citedby><cites>FETCH-LOGICAL-c2470-fccbe081a2671f98099315a9c214836fb4f4596f1742154a756c03f6b3b2626c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35444077$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maeda, Koki</creatorcontrib><creatorcontrib>Mori, Yuri</creatorcontrib><creatorcontrib>Nakamura, Masatoshi</creatorcontrib><creatorcontrib>Harada, Yoshimasa</creatorcontrib><creatorcontrib>Kodama, Kenichi</creatorcontrib><title>SYNDROME OF INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION AS A SIDE EFFECT OF CHEMOTHERAPY FOR URACHAL CARCINOMA: A CASE REPORT</title><title>Nihon Hinyokika Gakkai zasshi. The japanese journal of urology</title><addtitle>Jpn. j. urol</addtitle><description>A 54-year-old woman was admitted to our hospital complaining of gross hematuria and difficulty urinating. Cystoscopy revealed a tumor 4 cm in size with calcification on top of the bladder. After diagnosis of urachal carcinoma by transurethral resection of the bladder, partial cystectomy with en bloc resection of the median umbilical ligament and pelvic lymphadenectomy was performed. Pathological diagnosis confirmed urachal carcinoma, pT3b, ly1, v0, pN1, RM0. TS-1 and cisplatin chemotherapy (TS-1 at 100 mg/day on days 1-21, CDDP at 60 mg/m2 on day 8) was administered. On day 13, the patient was admitted because of consciousness disorder (Glasgow Coma Scale E2V1M4). Hyponatremia (Na 109 mEq/l) and renal excretion of sodium were present and the patient was diagnosed with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) induced by chemotherapy. Serum sodium level and her consciousness level gradually improved after administration of 3% saline. SIADH caused by chemotherapy containing cisplatin is a relatively rare, but potentially serious adverse effect that requires close attention.</description><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>chemotherapy</subject><subject>Cisplatin - adverse effects</subject><subject>Female</subject><subject>Humans</subject><subject>hyponatremia</subject><subject>Inappropriate ADH Syndrome - chemically induced</subject><subject>Inappropriate ADH Syndrome - diagnosis</subject><subject>Middle Aged</subject><subject>Research Report</subject><subject>Sodium - adverse effects</subject><subject>syndrome of inappropriate antidiuretic hormone secretion</subject><subject>Urinary Bladder Neoplasms</subject><subject>Vasopressins - adverse effects</subject><issn>0021-5287</issn><issn>1884-7110</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1vgkAURSdNm2qs-66a-QPY-YKB7ibjUEiUIQMuXBGYQqvxK6CLbvrbi7GadPWS9-49yTsAPGM0cQMfva4Pu_Wp3W8mGJMJRugODLHvM4djjO7BECGCHZf4fADGXbeqEMXcJz6lj2BAXcYY4nwIfrJlMjV6rqAOYZyINDU6NbHIFRRJHk_jhVF5LGGkzVwnCmZKnhc6gSKDAmbxVEEVhkrmZ4CM1FznkTIiXcJQG7gwQkZiBqUwMk70XLz1JSkyBY1KtcmfwENTbrp6_DdHYBGqXEbOTL_HUswcSxhHTmNtVSMfl8TjuOmfDwKK3TKwBDOfek3FGuYGXoM5I9hlJXc9i2jjVbQiHvEsHQF04dp233Vt3RSHdrUt2-8Co-Jss7jaLHqb_RL1lZdL5XCqtvXHrXB11weml8C6O5af9S1QtseV3dT_ieTKvZ3tV9kW9Y7-AoDpf88</recordid><startdate>20210420</startdate><enddate>20210420</enddate><creator>Maeda, Koki</creator><creator>Mori, Yuri</creator><creator>Nakamura, Masatoshi</creator><creator>Harada, Yoshimasa</creator><creator>Kodama, Kenichi</creator><general>THE JAPANESE UROLOGICAL ASSOCIATION</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20210420</creationdate><title>SYNDROME OF INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION AS A SIDE EFFECT OF CHEMOTHERAPY FOR URACHAL CARCINOMA: A CASE REPORT</title><author>Maeda, Koki ; Mori, Yuri ; Nakamura, Masatoshi ; Harada, Yoshimasa ; Kodama, Kenichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2470-fccbe081a2671f98099315a9c214836fb4f4596f1742154a756c03f6b3b2626c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; jpn</language><creationdate>2021</creationdate><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>chemotherapy</topic><topic>Cisplatin - adverse effects</topic><topic>Female</topic><topic>Humans</topic><topic>hyponatremia</topic><topic>Inappropriate ADH Syndrome - chemically induced</topic><topic>Inappropriate ADH Syndrome - diagnosis</topic><topic>Middle Aged</topic><topic>Research Report</topic><topic>Sodium - adverse effects</topic><topic>syndrome of inappropriate antidiuretic hormone secretion</topic><topic>Urinary Bladder Neoplasms</topic><topic>Vasopressins - adverse effects</topic><toplevel>online_resources</toplevel><creatorcontrib>Maeda, Koki</creatorcontrib><creatorcontrib>Mori, Yuri</creatorcontrib><creatorcontrib>Nakamura, Masatoshi</creatorcontrib><creatorcontrib>Harada, Yoshimasa</creatorcontrib><creatorcontrib>Kodama, Kenichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Nihon Hinyokika Gakkai zasshi. The japanese journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maeda, Koki</au><au>Mori, Yuri</au><au>Nakamura, Masatoshi</au><au>Harada, Yoshimasa</au><au>Kodama, Kenichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SYNDROME OF INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION AS A SIDE EFFECT OF CHEMOTHERAPY FOR URACHAL CARCINOMA: A CASE REPORT</atitle><jtitle>Nihon Hinyokika Gakkai zasshi. The japanese journal of urology</jtitle><addtitle>Jpn. j. urol</addtitle><date>2021-04-20</date><risdate>2021</risdate><volume>112</volume><issue>2</issue><spage>100</spage><epage>104</epage><pages>100-104</pages><issn>0021-5287</issn><eissn>1884-7110</eissn><abstract>A 54-year-old woman was admitted to our hospital complaining of gross hematuria and difficulty urinating. Cystoscopy revealed a tumor 4 cm in size with calcification on top of the bladder. After diagnosis of urachal carcinoma by transurethral resection of the bladder, partial cystectomy with en bloc resection of the median umbilical ligament and pelvic lymphadenectomy was performed. Pathological diagnosis confirmed urachal carcinoma, pT3b, ly1, v0, pN1, RM0. TS-1 and cisplatin chemotherapy (TS-1 at 100 mg/day on days 1-21, CDDP at 60 mg/m2 on day 8) was administered. On day 13, the patient was admitted because of consciousness disorder (Glasgow Coma Scale E2V1M4). Hyponatremia (Na 109 mEq/l) and renal excretion of sodium were present and the patient was diagnosed with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) induced by chemotherapy. Serum sodium level and her consciousness level gradually improved after administration of 3% saline. SIADH caused by chemotherapy containing cisplatin is a relatively rare, but potentially serious adverse effect that requires close attention.</abstract><cop>Japan</cop><pub>THE JAPANESE UROLOGICAL ASSOCIATION</pub><pmid>35444077</pmid><doi>10.5980/jpnjurol.112.100</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng ; jpn |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use chemotherapy Cisplatin - adverse effects Female Humans hyponatremia Inappropriate ADH Syndrome - chemically induced Inappropriate ADH Syndrome - diagnosis Middle Aged Research Report Sodium - adverse effects syndrome of inappropriate antidiuretic hormone secretion Urinary Bladder Neoplasms Vasopressins - adverse effects |
| title | SYNDROME OF INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION AS A SIDE EFFECT OF CHEMOTHERAPY FOR URACHAL CARCINOMA: A CASE REPORT |
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