A MODIFIED APPROACH TO THE ADOPTIVE IMMUNOTHERAPY OF WALKER-256 CARCINOSARCOMA WITH A COMBINATION OF ACTIVATED MACROPHAGES AND PHOTODYNAMIC THERAPY
Experiments were performed on five batches of Wistar inbred rats with Walker-256 carcinoma receiving sole (PDT, MAK) or combined therapy (PDT+MAK−A; PDT+MAK−B); the control batch (HBSS) consisted of animals with untreated tumors. The results were as follows: (a) the sole treatment (PDT, MAK) gave su...
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| Veröffentlicht in: | LASER THERAPY 2006, Vol.15(4), pp.151-160 |
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| creator | Dima, VF Vasiliu, V Laky, D Coman, N Ionescu, MD Dima, SV Nakaji, Shigeyuki |
| description | Experiments were performed on five batches of Wistar inbred rats with Walker-256 carcinoma receiving sole (PDT, MAK) or combined therapy (PDT+MAK−A; PDT+MAK−B); the control batch (HBSS) consisted of animals with untreated tumors. The results were as follows: (a) the sole treatment (PDT, MAK) gave survival rates between 37.7 and 47.5 %, the "combined" therapy in five doses increased significantly (70.8 %) the survival rate of tumor bearing rats as well as the rate of complete regression (82.1%). The cell-mediated immunity test and histopathological and as well as the electron microscopy observation were in full agreement with the results above. Summing up, this results demonstrate that "combined" photodynamic therapy with intra and peritumoral MAK infusion stimulated cell - mediated antitumoral activity, increased survival rates and reduces incidence of Walker-256 carcinoma in rat model. |
| doi_str_mv | 10.5978/islsm.15.151 |
| format | Article |
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The results were as follows: (a) the sole treatment (PDT, MAK) gave survival rates between 37.7 and 47.5 %, the "combined" therapy in five doses increased significantly (70.8 %) the survival rate of tumor bearing rats as well as the rate of complete regression (82.1%). The cell-mediated immunity test and histopathological and as well as the electron microscopy observation were in full agreement with the results above. Summing up, this results demonstrate that "combined" photodynamic therapy with intra and peritumoral MAK infusion stimulated cell - mediated antitumoral activity, increased survival rates and reduces incidence of Walker-256 carcinoma in rat model.</description><identifier>ISSN: 0898-5901</identifier><identifier>EISSN: 1884-7269</identifier><identifier>DOI: 10.5978/islsm.15.151</identifier><language>eng</language><publisher>International Phototherapy Association</publisher><subject>activated macrophages ; He-Ne laser ; multinucleated giant cells ; photodynamic therapy ; Photofrin II</subject><ispartof>LASER THERAPY, 2006, Vol.15(4), pp.151-160</ispartof><rights>2006 Japan Medical Laser Laboratory</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2691-f2aa4e241f79c02969a54001ec9cd73315dda75b3250ca70282e487ba2a656713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1878,4011,27905,27906,27907</link.rule.ids></links><search><creatorcontrib>Dima, VF</creatorcontrib><creatorcontrib>Vasiliu, V</creatorcontrib><creatorcontrib>Laky, D</creatorcontrib><creatorcontrib>Coman, N</creatorcontrib><creatorcontrib>Ionescu, MD</creatorcontrib><creatorcontrib>Dima, SV</creatorcontrib><creatorcontrib>Nakaji, Shigeyuki</creatorcontrib><title>A MODIFIED APPROACH TO THE ADOPTIVE IMMUNOTHERAPY OF WALKER-256 CARCINOSARCOMA WITH A COMBINATION OF ACTIVATED MACROPHAGES AND PHOTODYNAMIC THERAPY</title><title>LASER THERAPY</title><addtitle>LASER THERAPY</addtitle><description>Experiments were performed on five batches of Wistar inbred rats with Walker-256 carcinoma receiving sole (PDT, MAK) or combined therapy (PDT+MAK−A; PDT+MAK−B); the control batch (HBSS) consisted of animals with untreated tumors. 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Summing up, this results demonstrate that "combined" photodynamic therapy with intra and peritumoral MAK infusion stimulated cell - mediated antitumoral activity, increased survival rates and reduces incidence of Walker-256 carcinoma in rat model.</description><subject>activated macrophages</subject><subject>He-Ne laser</subject><subject>multinucleated giant cells</subject><subject>photodynamic therapy</subject><subject>Photofrin II</subject><issn>0898-5901</issn><issn>1884-7269</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNpFkFFPwjAQxxujiQR58wP0Azhsu3VdH89tsEa2LmNIeFrKGAoBNRsvfg6_sEUQL5f7X-5-ucsdQveUDLkUweOm23X7IeXW6RXq0SDwHMF8eY16JJCBwyWht2jQdVtizQ0k9VgPfQNOdaRGKo4w5HmhIUxwqXGZxBginZfqJcYqTWeZtqUC8gXWIzyHyXNcOIz7OIQiVJmeWtEp4LkqEwzY5k8qg1Lp7MhDaOdAaXekEBY6T2AcTzFkEc4TXepokUGqQnzecIdu1mbXNYOz9tFsFJdh4kz0WIUwcWp7FnXWzBivYR5dC1kTJn1puEcIbWpZr4TrUr5aGcGXLuOkNoKwgDVeIJaGGZ_7grp99HCaW7cfXdc26-qz3exN-1VRUh1_Wv3-tKLc-hGHE77tDua1ucCmPWzqXfMPe3-BXnr1m2mr5t39AXD8djQ</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Dima, VF</creator><creator>Vasiliu, V</creator><creator>Laky, D</creator><creator>Coman, N</creator><creator>Ionescu, MD</creator><creator>Dima, SV</creator><creator>Nakaji, Shigeyuki</creator><general>International Phototherapy Association</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2006</creationdate><title>A MODIFIED APPROACH TO THE ADOPTIVE IMMUNOTHERAPY OF WALKER-256 CARCINOSARCOMA WITH A COMBINATION OF ACTIVATED MACROPHAGES AND PHOTODYNAMIC THERAPY</title><author>Dima, VF ; Vasiliu, V ; Laky, D ; Coman, N ; Ionescu, MD ; Dima, SV ; Nakaji, Shigeyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2691-f2aa4e241f79c02969a54001ec9cd73315dda75b3250ca70282e487ba2a656713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>activated macrophages</topic><topic>He-Ne laser</topic><topic>multinucleated giant cells</topic><topic>photodynamic therapy</topic><topic>Photofrin II</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dima, VF</creatorcontrib><creatorcontrib>Vasiliu, V</creatorcontrib><creatorcontrib>Laky, D</creatorcontrib><creatorcontrib>Coman, N</creatorcontrib><creatorcontrib>Ionescu, MD</creatorcontrib><creatorcontrib>Dima, SV</creatorcontrib><creatorcontrib>Nakaji, Shigeyuki</creatorcontrib><collection>CrossRef</collection><jtitle>LASER THERAPY</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dima, VF</au><au>Vasiliu, V</au><au>Laky, D</au><au>Coman, N</au><au>Ionescu, MD</au><au>Dima, SV</au><au>Nakaji, Shigeyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A MODIFIED APPROACH TO THE ADOPTIVE IMMUNOTHERAPY OF WALKER-256 CARCINOSARCOMA WITH A COMBINATION OF ACTIVATED MACROPHAGES AND PHOTODYNAMIC THERAPY</atitle><jtitle>LASER THERAPY</jtitle><addtitle>LASER THERAPY</addtitle><date>2006</date><risdate>2006</risdate><volume>15</volume><issue>4</issue><spage>151</spage><epage>160</epage><pages>151-160</pages><issn>0898-5901</issn><eissn>1884-7269</eissn><abstract>Experiments were performed on five batches of Wistar inbred rats with Walker-256 carcinoma receiving sole (PDT, MAK) or combined therapy (PDT+MAK−A; PDT+MAK−B); the control batch (HBSS) consisted of animals with untreated tumors. 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| source | J-STAGE Free; EZB-FREE-00999 freely available EZB journals |
| subjects | activated macrophages He-Ne laser multinucleated giant cells photodynamic therapy Photofrin II |
| title | A MODIFIED APPROACH TO THE ADOPTIVE IMMUNOTHERAPY OF WALKER-256 CARCINOSARCOMA WITH A COMBINATION OF ACTIVATED MACROPHAGES AND PHOTODYNAMIC THERAPY |
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