IN VITRO EFFECT OF ISOSCHAFTOSIDE ISOLATED FROM Syngonium podophyllum ON PIG KIDNEY Na + , K + -ATPASE

IN VITRO EFFECT OF ISOSCHAFTOSIDE ISOLATED FROM Syngonium podophyllum ON PIG KIDNEY Na + , K + -ATPASE

The present study aimed to investigate the in vitro effects of isoschaftoside isolated from Syngonium podophyllum on pig kidney Na+,K+-ATPase. The Na+, K+-ATPase activity was determined by colorimetric measurement of inorganic phosphate (Pi), resulting from ATP hydrolysis. Isoschaftoside significant...

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Veröffentlicht in:Química Nova 2014, Vol.37 (10), p.1606-1609
Hauptverfasser: Gomes, Anne Caroline Candido, Sampaio, Luzia da Silva, Silva, Paulo André da, Lamas, Marcelo Einicker, Sakuragui, Cassia Mônica, Barreto Junior, Cleber Bomfim, Simas, Naomi Kato, Kuster, Ricardo Machado
Format: Artikel
Sprache:eng
Schlagworte:
Araceae
CHEMISTRY, MULTIDISCIPLINARY
enzyme inhibition
Isoschaftoside
renal Na+, K+-ATPase
Syngonium podophyllum
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Zusammenfassung:The present study aimed to investigate the in vitro effects of isoschaftoside isolated from Syngonium podophyllum on pig kidney Na+,K+-ATPase. The Na+, K+-ATPase activity was determined by colorimetric measurement of inorganic phosphate (Pi), resulting from ATP hydrolysis. Isoschaftoside significantly decreased the renal Na+, K+-ATPase activity at the highest concentration as well as at a lower concentration. Our work suggests that isoschaftoside is a promising compound for the treatment of hypertension.
ISSN:0100-4042
1678-7064
DOI:10.5935/0100-4042.20140257