Predictors of Mortality in Pulmonary Embolism: A Real-Life Study

Predictors of Mortality in Pulmonary Embolism: A Real-Life Study

Objective: The primary aim of this study was to investigate the mortality and associated factors in patients with pulmonary embolism. Methods: A retrospective analysis was performed on adult patients with pulmonary embolism who applied to X University Hospital between January 1, 2017, and January 1,...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:European journal of therapeutics 2023-09, Vol.29 (3), p.588-596
Hauptverfasser: Fakılı, Füsun, Taylan, Mahşuk, Bilgiç, İrem Zehra, Düzen, İrfan Veysel
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 596
container_issue 3
container_start_page 588
container_title European journal of therapeutics
container_volume 29
creator Fakılı, Füsun
Taylan, Mahşuk
Bilgiç, İrem Zehra
Düzen, İrfan Veysel
description Objective: The primary aim of this study was to investigate the mortality and associated factors in patients with pulmonary embolism. Methods: A retrospective analysis was performed on adult patients with pulmonary embolism who applied to X University Hospital between January 1, 2017, and January 1, 2023. All-cause mortality and related factors in pulmonary embolism patients were determined. Results: This study included 152 patients with a median age of 59 years and 81 (53.3%) women. The all-cause mortality rate was 25.7%, and pulmonary embolism-related deaths were 1.3%. Age (p
doi_str_mv 10.58600/eurjther1818
format Article
fullrecord <record><control><sourceid>crossref</sourceid><recordid>TN_cdi_crossref_primary_10_58600_eurjther1818</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_58600_eurjther1818</sourcerecordid><originalsourceid>FETCH-LOGICAL-c167t-4dc3df5f946e30124ce42392308721671c3a6433494a05ad5f274f94e7d494033</originalsourceid><addsrcrecordid>eNpNkEtLxDAcxIMouKx79J4vEM3jn6T15LKsrlBx8XEu2Tww0m4kaQ_99hYf4GmG4ccwDEKXjF7JSlF67cf8Mbz7zCpWnaAFlwqIpkBP_7yu4BytSokHCqCFkrpeoNt99i7aIeWCU8CPKQ-mi8OE4xHvx65PR5MnvO0PqYulv8Fr_OxNR5oYPH4ZRjddoLNguuJXv7pEb3fb182ONE_3D5t1QyxTeiDgrHBBhhqUF5RxsB64qLmgleYzwawwCoSAGgyVxsnANcy0126OqBBLRH56bU6lZB_azxz7eVzLaPv9QPv_AfEFKq1O9g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Predictors of Mortality in Pulmonary Embolism: A Real-Life Study</title><source>Alma/SFX Local Collection</source><creator>Fakılı, Füsun ; Taylan, Mahşuk ; Bilgiç, İrem Zehra ; Düzen, İrfan Veysel</creator><creatorcontrib>Fakılı, Füsun ; Taylan, Mahşuk ; Bilgiç, İrem Zehra ; Düzen, İrfan Veysel</creatorcontrib><description>Objective: The primary aim of this study was to investigate the mortality and associated factors in patients with pulmonary embolism. Methods: A retrospective analysis was performed on adult patients with pulmonary embolism who applied to X University Hospital between January 1, 2017, and January 1, 2023. All-cause mortality and related factors in pulmonary embolism patients were determined. Results: This study included 152 patients with a median age of 59 years and 81 (53.3%) women. The all-cause mortality rate was 25.7%, and pulmonary embolism-related deaths were 1.3%. Age (p&lt;0.001), chronic obstructive pulmonary disease (COPD) (p=0.013), heart failure (p=0.018), atrial fibrillation (p=0.015), massive pulmonary embolism (p=0.029), hemoglobin level (p&lt;0.001) and NT-Pro BNP level (p&lt;0.001) were significantly associated with increased all-cause mortality. In binary logistic regression analysis, for each unit of increasing pulmonary embolism severity index (PESI) score, mortality increased 2.2-fold (95% CI:1.03-5.09), massive PTE 1.6-fold (95% CI:0.14-17.86), anticoagulant duration (daily) 0.98-fold (95% CI:0.98-0.99) and Hb level (per unit Hb reduction) 0.67-fold (95% CI:0.45-1.02) mortality was increasing. There was no statistical difference between the number of hospitalization days for patients with low and high PESI and simplified PE severity index (sPESI) scores. Conclusions: All-cause mortality in patients with pulmonary embolism increased with age, cardiac diseases, and COPD comorbidities. The PESI and sPESI scores used in the acute phase of PTE were found to be highly reliable in predicting all-cause mortality in PE patients. The diagnosis of massive PE and elevated NT-proBNP levels, a marker of right ventricular dysfunction, were factors that increased mortality.</description><identifier>ISSN: 2564-7784</identifier><identifier>EISSN: 2564-7040</identifier><identifier>DOI: 10.58600/eurjther1818</identifier><language>eng</language><ispartof>European journal of therapeutics, 2023-09, Vol.29 (3), p.588-596</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c167t-4dc3df5f946e30124ce42392308721671c3a6433494a05ad5f274f94e7d494033</citedby><orcidid>0000-0003-4072-2270 ; 0000-0002-1602-5240 ; 0009-0008-8432-5617 ; 0000-0003-2312-4252</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Fakılı, Füsun</creatorcontrib><creatorcontrib>Taylan, Mahşuk</creatorcontrib><creatorcontrib>Bilgiç, İrem Zehra</creatorcontrib><creatorcontrib>Düzen, İrfan Veysel</creatorcontrib><title>Predictors of Mortality in Pulmonary Embolism: A Real-Life Study</title><title>European journal of therapeutics</title><description>Objective: The primary aim of this study was to investigate the mortality and associated factors in patients with pulmonary embolism. Methods: A retrospective analysis was performed on adult patients with pulmonary embolism who applied to X University Hospital between January 1, 2017, and January 1, 2023. All-cause mortality and related factors in pulmonary embolism patients were determined. Results: This study included 152 patients with a median age of 59 years and 81 (53.3%) women. The all-cause mortality rate was 25.7%, and pulmonary embolism-related deaths were 1.3%. Age (p&lt;0.001), chronic obstructive pulmonary disease (COPD) (p=0.013), heart failure (p=0.018), atrial fibrillation (p=0.015), massive pulmonary embolism (p=0.029), hemoglobin level (p&lt;0.001) and NT-Pro BNP level (p&lt;0.001) were significantly associated with increased all-cause mortality. In binary logistic regression analysis, for each unit of increasing pulmonary embolism severity index (PESI) score, mortality increased 2.2-fold (95% CI:1.03-5.09), massive PTE 1.6-fold (95% CI:0.14-17.86), anticoagulant duration (daily) 0.98-fold (95% CI:0.98-0.99) and Hb level (per unit Hb reduction) 0.67-fold (95% CI:0.45-1.02) mortality was increasing. There was no statistical difference between the number of hospitalization days for patients with low and high PESI and simplified PE severity index (sPESI) scores. Conclusions: All-cause mortality in patients with pulmonary embolism increased with age, cardiac diseases, and COPD comorbidities. The PESI and sPESI scores used in the acute phase of PTE were found to be highly reliable in predicting all-cause mortality in PE patients. The diagnosis of massive PE and elevated NT-proBNP levels, a marker of right ventricular dysfunction, were factors that increased mortality.</description><issn>2564-7784</issn><issn>2564-7040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpNkEtLxDAcxIMouKx79J4vEM3jn6T15LKsrlBx8XEu2Tww0m4kaQ_99hYf4GmG4ccwDEKXjF7JSlF67cf8Mbz7zCpWnaAFlwqIpkBP_7yu4BytSokHCqCFkrpeoNt99i7aIeWCU8CPKQ-mi8OE4xHvx65PR5MnvO0PqYulv8Fr_OxNR5oYPH4ZRjddoLNguuJXv7pEb3fb182ONE_3D5t1QyxTeiDgrHBBhhqUF5RxsB64qLmgleYzwawwCoSAGgyVxsnANcy0126OqBBLRH56bU6lZB_azxz7eVzLaPv9QPv_AfEFKq1O9g</recordid><startdate>20230901</startdate><enddate>20230901</enddate><creator>Fakılı, Füsun</creator><creator>Taylan, Mahşuk</creator><creator>Bilgiç, İrem Zehra</creator><creator>Düzen, İrfan Veysel</creator><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0003-4072-2270</orcidid><orcidid>https://orcid.org/0000-0002-1602-5240</orcidid><orcidid>https://orcid.org/0009-0008-8432-5617</orcidid><orcidid>https://orcid.org/0000-0003-2312-4252</orcidid></search><sort><creationdate>20230901</creationdate><title>Predictors of Mortality in Pulmonary Embolism: A Real-Life Study</title><author>Fakılı, Füsun ; Taylan, Mahşuk ; Bilgiç, İrem Zehra ; Düzen, İrfan Veysel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c167t-4dc3df5f946e30124ce42392308721671c3a6433494a05ad5f274f94e7d494033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fakılı, Füsun</creatorcontrib><creatorcontrib>Taylan, Mahşuk</creatorcontrib><creatorcontrib>Bilgiç, İrem Zehra</creatorcontrib><creatorcontrib>Düzen, İrfan Veysel</creatorcontrib><collection>CrossRef</collection><jtitle>European journal of therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fakılı, Füsun</au><au>Taylan, Mahşuk</au><au>Bilgiç, İrem Zehra</au><au>Düzen, İrfan Veysel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors of Mortality in Pulmonary Embolism: A Real-Life Study</atitle><jtitle>European journal of therapeutics</jtitle><date>2023-09-01</date><risdate>2023</risdate><volume>29</volume><issue>3</issue><spage>588</spage><epage>596</epage><pages>588-596</pages><issn>2564-7784</issn><eissn>2564-7040</eissn><abstract>Objective: The primary aim of this study was to investigate the mortality and associated factors in patients with pulmonary embolism. Methods: A retrospective analysis was performed on adult patients with pulmonary embolism who applied to X University Hospital between January 1, 2017, and January 1, 2023. All-cause mortality and related factors in pulmonary embolism patients were determined. Results: This study included 152 patients with a median age of 59 years and 81 (53.3%) women. The all-cause mortality rate was 25.7%, and pulmonary embolism-related deaths were 1.3%. Age (p&lt;0.001), chronic obstructive pulmonary disease (COPD) (p=0.013), heart failure (p=0.018), atrial fibrillation (p=0.015), massive pulmonary embolism (p=0.029), hemoglobin level (p&lt;0.001) and NT-Pro BNP level (p&lt;0.001) were significantly associated with increased all-cause mortality. In binary logistic regression analysis, for each unit of increasing pulmonary embolism severity index (PESI) score, mortality increased 2.2-fold (95% CI:1.03-5.09), massive PTE 1.6-fold (95% CI:0.14-17.86), anticoagulant duration (daily) 0.98-fold (95% CI:0.98-0.99) and Hb level (per unit Hb reduction) 0.67-fold (95% CI:0.45-1.02) mortality was increasing. There was no statistical difference between the number of hospitalization days for patients with low and high PESI and simplified PE severity index (sPESI) scores. Conclusions: All-cause mortality in patients with pulmonary embolism increased with age, cardiac diseases, and COPD comorbidities. The PESI and sPESI scores used in the acute phase of PTE were found to be highly reliable in predicting all-cause mortality in PE patients. The diagnosis of massive PE and elevated NT-proBNP levels, a marker of right ventricular dysfunction, were factors that increased mortality.</abstract><doi>10.58600/eurjther1818</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-4072-2270</orcidid><orcidid>https://orcid.org/0000-0002-1602-5240</orcidid><orcidid>https://orcid.org/0009-0008-8432-5617</orcidid><orcidid>https://orcid.org/0000-0003-2312-4252</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2564-7784
ispartof European journal of therapeutics, 2023-09, Vol.29 (3), p.588-596
issn 2564-7784
2564-7040
language eng
recordid cdi_crossref_primary_10_58600_eurjther1818
source Alma/SFX Local Collection
title Predictors of Mortality in Pulmonary Embolism: A Real-Life Study
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T17%3A55%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-crossref&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Predictors%20of%20Mortality%20in%20Pulmonary%20Embolism:%20A%20Real-Life%20Study&rft.jtitle=European%20journal%20of%20therapeutics&rft.au=Fak%C4%B1l%C4%B1,%20F%C3%BCsun&rft.date=2023-09-01&rft.volume=29&rft.issue=3&rft.spage=588&rft.epage=596&rft.pages=588-596&rft.issn=2564-7784&rft.eissn=2564-7040&rft_id=info:doi/10.58600/eurjther1818&rft_dat=%3Ccrossref%3E10_58600_eurjther1818%3C/crossref%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true