Usefulness of cell block method in endometrial cytology. The evaluation of Ebis 1 ver. 2/Hold Gel 110

Objective : The aim of this study was to improve diagnostic accuracy simply and efficiently by preparing paraffin-embedded cell blocks using Ebis 1 ver. 2/Hold Gel 110. Study Design : Subjects numbered 193 seen at a gynecology clinic. Using Hold Gel in routine endometrial cytology, we examined its usefulness. Results : Based on endometrial cytological evaluation, the 193 were divided into 174 negative cases, 8 indeterminate, and 3 with positive lesions. Evaluation using the cell block method resulted in 143 normal or benign, 6 suspected of endometrial hyperplasia, and 3 with adenocarcinoma. Cytological diagnosis and cell block concordance were 100% for negative, 37.5% for indeterminate, and 66.7% for positive. Cytologically indeterminate cases were divided into negative and positive using a cell block method. Cytological diagnosis and cell block method concordance were similar to those of histological examination. Conclusion : It appears to help in diagnosing endometrial lesions to observe both endometrial cytology specimens and slides from cell blocks using Hold Gel.