Cytological Changes in Vaginal Smear after Administration of Estrogen

Out of postmenopausal women, the cases where the result of the first cytological diagnosis was found false positive (especially 40 cases where diagnosis was. difficult), were treated with estrogen (premarin tablets 1.25mg/day) for successively 14 days. 3 days after the last tablets given, we performed the cytological diagnosis once more. Out of these 40 cases, the result was benign in 21 cases, false positive, in 2 cases, and malignant, in 17 cases. We obtained a 100% correct diagnosis. However, the period of treatment must be long, and there are still some point to improve. But the method is a practical and useful to make a diagnosis correctly.