Behavior of Dibucaine in its Parenteral Solution Preparation Process Accompanied by High-pressure Steam Sterilization and Characterization of a Degradation Product Formed from Dibucaine by Thermal Treatment

We found that an impurity was formed in the 1% dibucaine injection solution following ordinal treatment using the high-pressure steam method. The impurity was isolated and characterized to be 2-hydroxy-N-[2-(diethylamino) ethy1-4-quinolinecarboxamine (debutyl-dibucaine)], which was caused from the t...

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Veröffentlicht in:	Byōin yakugaku 1995/08/10, Vol.21(4), pp.319-326
Hauptverfasser:	ITO, YOKO, NAGAO, YASUHIRO, IDA, YOSHITERU, YAMAMOTO, TOSHINORI, KUROIWA, YUKIO
Format:	Artikel
Sprache:	eng ; jpn
Schlagworte:	dibucaine injection HPLC lumbar anesthesia steam sterilization under pressure
Online-Zugang:	Volltext
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