Compatibility between Drugs and Photodegradation of Sustained Release Fine Granules of Nifedipine
Compatibility of sustained-released fine granules of nifedipine (SRN) with 21 kinds of drug were studied. The mixtures of SRN and drugs in heat-sealed packages (polyethylene-laminated glassine paper) were kept at 20°C and 75% relative humidity (R. H.) or 30°C and 92% R. H. for 30 days. Weight change...
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| Veröffentlicht in: | Byōin yakugaku 1993/10/20, Vol.19(5), pp.427-434 |
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| container_title | Byōin yakugaku |
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| creator | YAGI, NAOMI KENMOTSU, HARUMI SEKIKAWA, HITOSHI SAIJO, KAZUYOKU NISHIHANA, MASAKI KATAKURA, MICHIHIRO ITAYA, KOICHI |
| description | Compatibility of sustained-released fine granules of nifedipine (SRN) with 21 kinds of drug were studied. The mixtures of SRN and drugs in heat-sealed packages (polyethylene-laminated glassine paper) were kept at 20°C and 75% relative humidity (R. H.) or 30°C and 92% R. H. for 30 days. Weight change and color of samples were recorded. Dissolution tests of nifedipine from the mixtures of SRN and the drugs were studied in J. P. disintegration media No.1 and No.2. Significant incompatibility was not observed in the weight change, nor was significant change of dissolution of nifedipine noted except for the combination with sodium bicarbonate. Dissolution of nifedipine was enhanced by sodium bicarbonate in disintegration medium No.1. We further studied photodegradation of nifedipine in SRN. Fluorescent light was irradiated (1000 lx) on SRN in a petridish wrapped with polyvinylidenchloride film, in a heat-sealed package, in a heat-sealed package kept in a paper bag, and in a heat-sealed package kept in a light-resistant multi-layered laminate bag. Except for the light-resistant bag, light irradiation produced considerable unstability in nifedipine in SRN. |
| doi_str_mv | 10.5649/jjphcs1975.19.427 |
| format | Article |
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The mixtures of SRN and drugs in heat-sealed packages (polyethylene-laminated glassine paper) were kept at 20°C and 75% relative humidity (R. H.) or 30°C and 92% R. H. for 30 days. Weight change and color of samples were recorded. Dissolution tests of nifedipine from the mixtures of SRN and the drugs were studied in J. P. disintegration media No.1 and No.2. Significant incompatibility was not observed in the weight change, nor was significant change of dissolution of nifedipine noted except for the combination with sodium bicarbonate. Dissolution of nifedipine was enhanced by sodium bicarbonate in disintegration medium No.1. We further studied photodegradation of nifedipine in SRN. Fluorescent light was irradiated (1000 lx) on SRN in a petridish wrapped with polyvinylidenchloride film, in a heat-sealed package, in a heat-sealed package kept in a paper bag, and in a heat-sealed package kept in a light-resistant multi-layered laminate bag. Except for the light-resistant bag, light irradiation produced considerable unstability in nifedipine in SRN.</description><identifier>ISSN: 0389-9098</identifier><identifier>EISSN: 2185-9477</identifier><identifier>DOI: 10.5649/jjphcs1975.19.427</identifier><language>eng ; jpn</language><publisher>Japanese Society of Pharmaceutical Health Care and Sciences</publisher><subject>compatibility ; dissolution ; nifedipine ; photodegradation ; sustained release</subject><ispartof>Japanese Journal of Hospital Pharmacy, 1993/10/20, Vol.19(5), pp.427-434</ispartof><rights>Japanese Society of Pharmaceutical Health Care and Sciences</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2537-6b5753ce29170bffaeac14ef3c1d1a357e736f4943809c858c84a5d7d8d9f0b33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids></links><search><creatorcontrib>YAGI, NAOMI</creatorcontrib><creatorcontrib>KENMOTSU, HARUMI</creatorcontrib><creatorcontrib>SEKIKAWA, HITOSHI</creatorcontrib><creatorcontrib>SAIJO, KAZUYOKU</creatorcontrib><creatorcontrib>NISHIHANA, MASAKI</creatorcontrib><creatorcontrib>KATAKURA, MICHIHIRO</creatorcontrib><creatorcontrib>ITAYA, KOICHI</creatorcontrib><title>Compatibility between Drugs and Photodegradation of Sustained Release Fine Granules of Nifedipine</title><title>Byōin yakugaku</title><addtitle>Japanese Journal of Hospital Pharmacy</addtitle><description>Compatibility of sustained-released fine granules of nifedipine (SRN) with 21 kinds of drug were studied. 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Except for the light-resistant bag, light irradiation produced considerable unstability in nifedipine in SRN.</description><subject>compatibility</subject><subject>dissolution</subject><subject>nifedipine</subject><subject>photodegradation</subject><subject>sustained release</subject><issn>0389-9098</issn><issn>2185-9477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><recordid>eNpdkF9LwzAUxYMoOOY-gG_5Ap1J0zTJo0w3B0PFP88lTW62jK4tSYfs25uxMcGXezmX87twDkL3lEx5WaiH7bbfmEiV4FOqpkUurtAop5JnqhDiGo0IkypTRMlbNInR1yRntEySj5CedbteD772jR8OuIbhB6DFT2G_jli3Fr9vuqGzsA7aJlvX4s7hz30ctG_B4g9oQEfA86TwIuh230A8Wl69A-v7dL5DN043ESbnPUbf8-ev2Uu2elssZ4-rzOSciaysueDMQK6oILVzGrShBThmqKWacQGCla5QBZNEGcmlkYXmVlhplSM1Y2NET39N6GIM4Ko--J0Oh4qS6lhT9VdTRVWVakrM_MRsU6A1XAgdBm8a-EecRwIvBrPRoYKW_QKVf3eN</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>YAGI, NAOMI</creator><creator>KENMOTSU, HARUMI</creator><creator>SEKIKAWA, HITOSHI</creator><creator>SAIJO, KAZUYOKU</creator><creator>NISHIHANA, MASAKI</creator><creator>KATAKURA, MICHIHIRO</creator><creator>ITAYA, KOICHI</creator><general>Japanese Society of Pharmaceutical Health Care and Sciences</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1993</creationdate><title>Compatibility between Drugs and Photodegradation of Sustained Release Fine Granules of Nifedipine</title><author>YAGI, NAOMI ; KENMOTSU, HARUMI ; SEKIKAWA, HITOSHI ; SAIJO, KAZUYOKU ; NISHIHANA, MASAKI ; KATAKURA, MICHIHIRO ; ITAYA, KOICHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2537-6b5753ce29170bffaeac14ef3c1d1a357e736f4943809c858c84a5d7d8d9f0b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; jpn</language><creationdate>1993</creationdate><topic>compatibility</topic><topic>dissolution</topic><topic>nifedipine</topic><topic>photodegradation</topic><topic>sustained release</topic><toplevel>online_resources</toplevel><creatorcontrib>YAGI, NAOMI</creatorcontrib><creatorcontrib>KENMOTSU, HARUMI</creatorcontrib><creatorcontrib>SEKIKAWA, HITOSHI</creatorcontrib><creatorcontrib>SAIJO, KAZUYOKU</creatorcontrib><creatorcontrib>NISHIHANA, MASAKI</creatorcontrib><creatorcontrib>KATAKURA, MICHIHIRO</creatorcontrib><creatorcontrib>ITAYA, KOICHI</creatorcontrib><collection>CrossRef</collection><jtitle>Byōin yakugaku</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YAGI, NAOMI</au><au>KENMOTSU, HARUMI</au><au>SEKIKAWA, HITOSHI</au><au>SAIJO, KAZUYOKU</au><au>NISHIHANA, MASAKI</au><au>KATAKURA, MICHIHIRO</au><au>ITAYA, KOICHI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Compatibility between Drugs and Photodegradation of Sustained Release Fine Granules of Nifedipine</atitle><jtitle>Byōin yakugaku</jtitle><addtitle>Japanese Journal of Hospital Pharmacy</addtitle><date>1993</date><risdate>1993</risdate><volume>19</volume><issue>5</issue><spage>427</spage><epage>434</epage><pages>427-434</pages><issn>0389-9098</issn><eissn>2185-9477</eissn><abstract>Compatibility of sustained-released fine granules of nifedipine (SRN) with 21 kinds of drug were studied. The mixtures of SRN and drugs in heat-sealed packages (polyethylene-laminated glassine paper) were kept at 20°C and 75% relative humidity (R. H.) or 30°C and 92% R. H. for 30 days. Weight change and color of samples were recorded. Dissolution tests of nifedipine from the mixtures of SRN and the drugs were studied in J. P. disintegration media No.1 and No.2. Significant incompatibility was not observed in the weight change, nor was significant change of dissolution of nifedipine noted except for the combination with sodium bicarbonate. Dissolution of nifedipine was enhanced by sodium bicarbonate in disintegration medium No.1. We further studied photodegradation of nifedipine in SRN. Fluorescent light was irradiated (1000 lx) on SRN in a petridish wrapped with polyvinylidenchloride film, in a heat-sealed package, in a heat-sealed package kept in a paper bag, and in a heat-sealed package kept in a light-resistant multi-layered laminate bag. Except for the light-resistant bag, light irradiation produced considerable unstability in nifedipine in SRN.</abstract><pub>Japanese Society of Pharmaceutical Health Care and Sciences</pub><doi>10.5649/jjphcs1975.19.427</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0389-9098 |
| ispartof | Japanese Journal of Hospital Pharmacy, 1993/10/20, Vol.19(5), pp.427-434 |
| issn | 0389-9098 2185-9477 |
| language | eng ; jpn |
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| source | J-STAGE Free; Freely Accessible Japanese Titles; EZB-FREE-00999 freely available EZB journals |
| subjects | compatibility dissolution nifedipine photodegradation sustained release |
| title | Compatibility between Drugs and Photodegradation of Sustained Release Fine Granules of Nifedipine |
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