Effects of Etoposide Injection on the Final Filter

The hydrophilic membrane of a final filter was dissolved by etoposide injection (Lastet) when administered to a child with acute lymphoblastic leukemia by the continuous dosing method applied through a final filter. The objective of this investigation was to evaluate the effecacy (appearance, bubble point pressure and durability) of five final filters using etoposide injection and adjuvants. The results suggest that polyethylene glycol and ethanol in etoposide injection dissolved the cellulose membrane of the final filter, whereas the teflon membrane of the syringe-operated filter unit was valuable.