Quality Examination of 7% Lidocaine Cream Prepared in Our Hospital
A local anesthetic preparation to be applied on skin surface, 7% lidocaine cream, was prepared and was stored for one year under a room temperature (25±2°C) to test the stability. The appearance was visually inspected, lidocaine content was determined by high-performance liquid chromatography (HPLC)...
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| Veröffentlicht in: | Byōin yakugaku 1992/10/20, Vol.18(5), pp.486-490 |
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| container_issue | 5 |
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| container_title | Byōin yakugaku |
| container_volume | 18 |
| creator | FUJII, TADAO NAKABAYASHI, HIROMI ICHIKAWA, SATOSHI NINOMIYA, SAYOSHI SHIBATA, MIKIO MIZUSHIMA, NORIKO MIYASAKA, MUNEO |
| description | A local anesthetic preparation to be applied on skin surface, 7% lidocaine cream, was prepared and was stored for one year under a room temperature (25±2°C) to test the stability. The appearance was visually inspected, lidocaine content was determined by high-performance liquid chromatography (HPLC), and water content was measured according to the Karl Fisher method described in the Japanese Pharmacopeia.The transdermal absorption and the anesthetic effect were also compared between the 7% lidocaine cream and EMLA cream (ASTRA) which is used in Europe.The transdermal absorption was estimated from the remaining drug in the cream one hour after application. The anesthetic effect was assessed according to the pinprick method. Little changes in both lidocaine content and water content of the 7% lidocaine cream were observed one year after the preparation, which proved its satisfactory stability.Although it was estimated that the amount of drug absorbed was smaller with 7% lidocaine cream than that with EMLA cream, both creams had an almost equivalent anesthetic effect. |
| doi_str_mv | 10.5649/jjphcs1975.18.486 |
| format | Article |
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The appearance was visually inspected, lidocaine content was determined by high-performance liquid chromatography (HPLC), and water content was measured according to the Karl Fisher method described in the Japanese Pharmacopeia.The transdermal absorption and the anesthetic effect were also compared between the 7% lidocaine cream and EMLA cream (ASTRA) which is used in Europe.The transdermal absorption was estimated from the remaining drug in the cream one hour after application. The anesthetic effect was assessed according to the pinprick method. Little changes in both lidocaine content and water content of the 7% lidocaine cream were observed one year after the preparation, which proved its satisfactory stability.Although it was estimated that the amount of drug absorbed was smaller with 7% lidocaine cream than that with EMLA cream, both creams had an almost equivalent anesthetic effect.</description><identifier>ISSN: 0389-9098</identifier><identifier>EISSN: 2185-9477</identifier><identifier>DOI: 10.5649/jjphcs1975.18.486</identifier><language>eng ; jpn</language><publisher>Japanese Society of Pharmaceutical Health Care and Sciences</publisher><subject>EMLA cream ; HPLC ; lidocaine cream ; local anaesthetic agent ; pin-prick test ; stability</subject><ispartof>Japanese Journal of Hospital Pharmacy, 1992/10/20, Vol.18(5), pp.486-490</ispartof><rights>Japanese Society of Pharmaceutical Health Care and Sciences</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2536-8c9ad1b8ec6bcba45a7eecbac23691ec1f9055b793a20f4d58c8c455c63aa5f83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids></links><search><creatorcontrib>FUJII, TADAO</creatorcontrib><creatorcontrib>NAKABAYASHI, HIROMI</creatorcontrib><creatorcontrib>ICHIKAWA, SATOSHI</creatorcontrib><creatorcontrib>NINOMIYA, SAYOSHI</creatorcontrib><creatorcontrib>SHIBATA, MIKIO</creatorcontrib><creatorcontrib>MIZUSHIMA, NORIKO</creatorcontrib><creatorcontrib>MIYASAKA, MUNEO</creatorcontrib><title>Quality Examination of 7% Lidocaine Cream Prepared in Our Hospital</title><title>Byōin yakugaku</title><addtitle>Japanese Journal of Hospital Pharmacy</addtitle><description>A local anesthetic preparation to be applied on skin surface, 7% lidocaine cream, was prepared and was stored for one year under a room temperature (25±2°C) to test the stability. 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Little changes in both lidocaine content and water content of the 7% lidocaine cream were observed one year after the preparation, which proved its satisfactory stability.Although it was estimated that the amount of drug absorbed was smaller with 7% lidocaine cream than that with EMLA cream, both creams had an almost equivalent anesthetic effect.</description><subject>EMLA cream</subject><subject>HPLC</subject><subject>lidocaine cream</subject><subject>local anaesthetic agent</subject><subject>pin-prick test</subject><subject>stability</subject><issn>0389-9098</issn><issn>2185-9477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><recordid>eNpdkEFLwzAUx4MoOOY-gLdcPHYmTZMmRx2bEwpT0HN4fU1dRteWpAP37a1sTPDy_u_B-_0PP0LuOZtLlZnH3a7fYuQml3Ou55lWV2SSci0Tk-X5NZkwoU1imNG3ZBajL1kquBpPOSHP7wdo_HCky2_Y-xYG37W0q2n-QAtfdQi-dXQRHOzpW3A9BFdR39LNIdB1F3s_QHNHbmpoopudc0o-V8uPxTopNi-vi6ciwVQKlWg0UPFSO1QllpBJyJ0bF0yFMtwhrw2TssyNgJTVWSU1asykRCUAZK3FlPBTL4YuxuBq2we_h3C0nNlfD_bPg-Xajh5GZnVidnGAL3chIAweG_ePOI8RvDzgFoJ1rfgBLRFrwA</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>FUJII, TADAO</creator><creator>NAKABAYASHI, HIROMI</creator><creator>ICHIKAWA, SATOSHI</creator><creator>NINOMIYA, SAYOSHI</creator><creator>SHIBATA, MIKIO</creator><creator>MIZUSHIMA, NORIKO</creator><creator>MIYASAKA, MUNEO</creator><general>Japanese Society of Pharmaceutical Health Care and Sciences</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1992</creationdate><title>Quality Examination of 7% Lidocaine Cream Prepared in Our Hospital</title><author>FUJII, TADAO ; NAKABAYASHI, HIROMI ; ICHIKAWA, SATOSHI ; NINOMIYA, SAYOSHI ; SHIBATA, MIKIO ; MIZUSHIMA, NORIKO ; MIYASAKA, MUNEO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2536-8c9ad1b8ec6bcba45a7eecbac23691ec1f9055b793a20f4d58c8c455c63aa5f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; jpn</language><creationdate>1992</creationdate><topic>EMLA cream</topic><topic>HPLC</topic><topic>lidocaine cream</topic><topic>local anaesthetic agent</topic><topic>pin-prick test</topic><topic>stability</topic><toplevel>online_resources</toplevel><creatorcontrib>FUJII, TADAO</creatorcontrib><creatorcontrib>NAKABAYASHI, HIROMI</creatorcontrib><creatorcontrib>ICHIKAWA, SATOSHI</creatorcontrib><creatorcontrib>NINOMIYA, SAYOSHI</creatorcontrib><creatorcontrib>SHIBATA, MIKIO</creatorcontrib><creatorcontrib>MIZUSHIMA, NORIKO</creatorcontrib><creatorcontrib>MIYASAKA, MUNEO</creatorcontrib><collection>CrossRef</collection><jtitle>Byōin yakugaku</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FUJII, TADAO</au><au>NAKABAYASHI, HIROMI</au><au>ICHIKAWA, SATOSHI</au><au>NINOMIYA, SAYOSHI</au><au>SHIBATA, MIKIO</au><au>MIZUSHIMA, NORIKO</au><au>MIYASAKA, MUNEO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quality Examination of 7% Lidocaine Cream Prepared in Our Hospital</atitle><jtitle>Byōin yakugaku</jtitle><addtitle>Japanese Journal of Hospital Pharmacy</addtitle><date>1992</date><risdate>1992</risdate><volume>18</volume><issue>5</issue><spage>486</spage><epage>490</epage><pages>486-490</pages><issn>0389-9098</issn><eissn>2185-9477</eissn><abstract>A local anesthetic preparation to be applied on skin surface, 7% lidocaine cream, was prepared and was stored for one year under a room temperature (25±2°C) to test the stability. The appearance was visually inspected, lidocaine content was determined by high-performance liquid chromatography (HPLC), and water content was measured according to the Karl Fisher method described in the Japanese Pharmacopeia.The transdermal absorption and the anesthetic effect were also compared between the 7% lidocaine cream and EMLA cream (ASTRA) which is used in Europe.The transdermal absorption was estimated from the remaining drug in the cream one hour after application. The anesthetic effect was assessed according to the pinprick method. Little changes in both lidocaine content and water content of the 7% lidocaine cream were observed one year after the preparation, which proved its satisfactory stability.Although it was estimated that the amount of drug absorbed was smaller with 7% lidocaine cream than that with EMLA cream, both creams had an almost equivalent anesthetic effect.</abstract><pub>Japanese Society of Pharmaceutical Health Care and Sciences</pub><doi>10.5649/jjphcs1975.18.486</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0389-9098 |
| ispartof | Japanese Journal of Hospital Pharmacy, 1992/10/20, Vol.18(5), pp.486-490 |
| issn | 0389-9098 2185-9477 |
| language | eng ; jpn |
| recordid | cdi_crossref_primary_10_5649_jjphcs1975_18_486 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Open Access Titles of Japan |
| subjects | EMLA cream HPLC lidocaine cream local anaesthetic agent pin-prick test stability |
| title | Quality Examination of 7% Lidocaine Cream Prepared in Our Hospital |
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