Determination of Serum Mexiletine Concentrations and its Protein Binding by High-performance Liquid Chromatography

A new method to determine serum mexiletine (MX) concentrations using high-performance liquid chromatography (HPLC) was established.This method could reduce a sample volume to 100μ1 of serum and could shorten the pretreatment time to less than 10 minutes by using Chem Elut minicolumn. The results obt...

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Veröffentlicht in:	Byōin yakugaku 1992/10/20, Vol.18(5), pp.477-485
Hauptverfasser:	KUROYAMA, MASAKAZU, MURASE, SETSUKO, KASAI, YURIKO, SAGAWA, KENICHI, KOBAYASHI, TERUAKI, TOMONAGA, FUMIYA, KUBO, HIROAKI, KUMANO, KAZUO
Format:	Artikel
Sprache:	jpn
Schlagworte:	chronic renal failure high-performance liquid chromatography mexiletine protein binding
Online-Zugang:	Volltext
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