Impact of serum alkaline phosphatase level on coronary collateral circulation
Serum alkaline phosphatase (ALP) level has been shown to be a prognostic factor for myocardial infarction and stroke via its promotion of vascular calcification. To investigate for the first time the correlation between serum ALP level and coronary collateral circulation (CCC) development. A total o...
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| Veröffentlicht in: | Kardiologia polska 2014-01, Vol.72 (12), p.1388-1393 |
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| container_title | Kardiologia polska |
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| creator | Karabulut, Ahmet Sahin, Irfan Avci, Ilhan Ilker Okuyan, Ertugrul Dogan, Zeki Uzunlar, Bulent Satilmis, Seckin |
| description | Serum alkaline phosphatase (ALP) level has been shown to be a prognostic factor for myocardial infarction and stroke via its promotion of vascular calcification.
To investigate for the first time the correlation between serum ALP level and coronary collateral circulation (CCC) development.
A total of 356 patients with stable angina pectoris were evaluated retrospectively. Patients were classified according to ALP level and CCC grade. Rentrop 0-1 flow was defined as impaired CCC. Serum ALP > 129 mg/dL in men and > 104 mg/dL in women was defined as elevated ALP. All groups were compared statistically according to clinical, laboratory and demographic features.
Impaired CCC was observed in 53.7% of the patients. The mean ALP level was 102.8 ± 57.9 mg/dL, and elevated ALP levels were obtained in 19.4% of cases. There was a significant correlation between ALP and CCC grade, and impaired CCC was associated with relatively higher ALP values (65.2% vs. 50.9%, p = 0.03). Multivariate regression analysis also showed a significant correlation between elevated ALP level and impaired CCC (OR 1.85, with a 95% CI 1.056-3.264; p = 0.03).
Serum ALP is a widely avaliable unfavourable prognostic parameter in coronary heart disease. Elevated ALP levels were associated with inadequate CCC, which supports the previously reported literature concerning the negative prognostic value of ALP levels in cardiovascular settings. |
| doi_str_mv | 10.5603/KP.a2014.0114 |
| format | Article |
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To investigate for the first time the correlation between serum ALP level and coronary collateral circulation (CCC) development.
A total of 356 patients with stable angina pectoris were evaluated retrospectively. Patients were classified according to ALP level and CCC grade. Rentrop 0-1 flow was defined as impaired CCC. Serum ALP > 129 mg/dL in men and > 104 mg/dL in women was defined as elevated ALP. All groups were compared statistically according to clinical, laboratory and demographic features.
Impaired CCC was observed in 53.7% of the patients. The mean ALP level was 102.8 ± 57.9 mg/dL, and elevated ALP levels were obtained in 19.4% of cases. There was a significant correlation between ALP and CCC grade, and impaired CCC was associated with relatively higher ALP values (65.2% vs. 50.9%, p = 0.03). Multivariate regression analysis also showed a significant correlation between elevated ALP level and impaired CCC (OR 1.85, with a 95% CI 1.056-3.264; p = 0.03).
Serum ALP is a widely avaliable unfavourable prognostic parameter in coronary heart disease. Elevated ALP levels were associated with inadequate CCC, which supports the previously reported literature concerning the negative prognostic value of ALP levels in cardiovascular settings.</description><identifier>ISSN: 0022-9032</identifier><identifier>EISSN: 1897-4279</identifier><identifier>DOI: 10.5603/KP.a2014.0114</identifier><identifier>PMID: 24846368</identifier><language>eng</language><publisher>Poland</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Alkaline Phosphatase - blood ; Biomarkers - blood ; Collateral Circulation - physiology ; Coronary Artery Disease - blood ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies</subject><ispartof>Kardiologia polska, 2014-01, Vol.72 (12), p.1388-1393</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-180e9de015e6ab3e3bda6634aeae942524d8eb4426cd31e7979fdfa888c70b803</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24846368$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karabulut, Ahmet</creatorcontrib><creatorcontrib>Sahin, Irfan</creatorcontrib><creatorcontrib>Avci, Ilhan Ilker</creatorcontrib><creatorcontrib>Okuyan, Ertugrul</creatorcontrib><creatorcontrib>Dogan, Zeki</creatorcontrib><creatorcontrib>Uzunlar, Bulent</creatorcontrib><creatorcontrib>Satilmis, Seckin</creatorcontrib><title>Impact of serum alkaline phosphatase level on coronary collateral circulation</title><title>Kardiologia polska</title><addtitle>Kardiol Pol</addtitle><description>Serum alkaline phosphatase (ALP) level has been shown to be a prognostic factor for myocardial infarction and stroke via its promotion of vascular calcification.
To investigate for the first time the correlation between serum ALP level and coronary collateral circulation (CCC) development.
A total of 356 patients with stable angina pectoris were evaluated retrospectively. Patients were classified according to ALP level and CCC grade. Rentrop 0-1 flow was defined as impaired CCC. Serum ALP > 129 mg/dL in men and > 104 mg/dL in women was defined as elevated ALP. All groups were compared statistically according to clinical, laboratory and demographic features.
Impaired CCC was observed in 53.7% of the patients. The mean ALP level was 102.8 ± 57.9 mg/dL, and elevated ALP levels were obtained in 19.4% of cases. There was a significant correlation between ALP and CCC grade, and impaired CCC was associated with relatively higher ALP values (65.2% vs. 50.9%, p = 0.03). Multivariate regression analysis also showed a significant correlation between elevated ALP level and impaired CCC (OR 1.85, with a 95% CI 1.056-3.264; p = 0.03).
Serum ALP is a widely avaliable unfavourable prognostic parameter in coronary heart disease. Elevated ALP levels were associated with inadequate CCC, which supports the previously reported literature concerning the negative prognostic value of ALP levels in cardiovascular settings.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alkaline Phosphatase - blood</subject><subject>Biomarkers - blood</subject><subject>Collateral Circulation - physiology</subject><subject>Coronary Artery Disease - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><issn>0022-9032</issn><issn>1897-4279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOwzAQRS0EoqWwZIv8Ayl-1bGXqOJRtYguYB1NnIkacOLITpH4e1IKrO5c6Wh0dQi55my-0EzerrdzEIyrOeNcnZApNzbPlMjtKZkyJkRmmRQTcpHS-1iN5vycTIQySkttpuR51fbgBhpqmjDuWwr-A3zTIe13IfU7GCAh9fiJnoaOuhBDB_FrPLyHASN46pro9mNpQndJzmrwCa9-c0beHu5fl0_Z5uVxtbzbZE5KMWTcMLQVMr5ADaVEWVagtVSAgFaJhVCVwVIpoV0lOeY2t3VVgzHG5aw0TM5IdvzrYkgpYl30sWnHXQVnxUFLsd4WP1qKg5aRvzny_b5ssfqn_zzIb3uTXt4</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Karabulut, Ahmet</creator><creator>Sahin, Irfan</creator><creator>Avci, Ilhan Ilker</creator><creator>Okuyan, Ertugrul</creator><creator>Dogan, Zeki</creator><creator>Uzunlar, Bulent</creator><creator>Satilmis, Seckin</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20140101</creationdate><title>Impact of serum alkaline phosphatase level on coronary collateral circulation</title><author>Karabulut, Ahmet ; Sahin, Irfan ; Avci, Ilhan Ilker ; Okuyan, Ertugrul ; Dogan, Zeki ; Uzunlar, Bulent ; Satilmis, Seckin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-180e9de015e6ab3e3bda6634aeae942524d8eb4426cd31e7979fdfa888c70b803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alkaline Phosphatase - blood</topic><topic>Biomarkers - blood</topic><topic>Collateral Circulation - physiology</topic><topic>Coronary Artery Disease - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karabulut, Ahmet</creatorcontrib><creatorcontrib>Sahin, Irfan</creatorcontrib><creatorcontrib>Avci, Ilhan Ilker</creatorcontrib><creatorcontrib>Okuyan, Ertugrul</creatorcontrib><creatorcontrib>Dogan, Zeki</creatorcontrib><creatorcontrib>Uzunlar, Bulent</creatorcontrib><creatorcontrib>Satilmis, Seckin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Kardiologia polska</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karabulut, Ahmet</au><au>Sahin, Irfan</au><au>Avci, Ilhan Ilker</au><au>Okuyan, Ertugrul</au><au>Dogan, Zeki</au><au>Uzunlar, Bulent</au><au>Satilmis, Seckin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of serum alkaline phosphatase level on coronary collateral circulation</atitle><jtitle>Kardiologia polska</jtitle><addtitle>Kardiol Pol</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>72</volume><issue>12</issue><spage>1388</spage><epage>1393</epage><pages>1388-1393</pages><issn>0022-9032</issn><eissn>1897-4279</eissn><abstract>Serum alkaline phosphatase (ALP) level has been shown to be a prognostic factor for myocardial infarction and stroke via its promotion of vascular calcification.
To investigate for the first time the correlation between serum ALP level and coronary collateral circulation (CCC) development.
A total of 356 patients with stable angina pectoris were evaluated retrospectively. Patients were classified according to ALP level and CCC grade. Rentrop 0-1 flow was defined as impaired CCC. Serum ALP > 129 mg/dL in men and > 104 mg/dL in women was defined as elevated ALP. All groups were compared statistically according to clinical, laboratory and demographic features.
Impaired CCC was observed in 53.7% of the patients. The mean ALP level was 102.8 ± 57.9 mg/dL, and elevated ALP levels were obtained in 19.4% of cases. There was a significant correlation between ALP and CCC grade, and impaired CCC was associated with relatively higher ALP values (65.2% vs. 50.9%, p = 0.03). Multivariate regression analysis also showed a significant correlation between elevated ALP level and impaired CCC (OR 1.85, with a 95% CI 1.056-3.264; p = 0.03).
Serum ALP is a widely avaliable unfavourable prognostic parameter in coronary heart disease. Elevated ALP levels were associated with inadequate CCC, which supports the previously reported literature concerning the negative prognostic value of ALP levels in cardiovascular settings.</abstract><cop>Poland</cop><pmid>24846368</pmid><doi>10.5603/KP.a2014.0114</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Aged, 80 and over Alkaline Phosphatase - blood Biomarkers - blood Collateral Circulation - physiology Coronary Artery Disease - blood Female Humans Male Middle Aged Retrospective Studies |
| title | Impact of serum alkaline phosphatase level on coronary collateral circulation |
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