Apelin in ST segment elevation and non-ST segment elevation acute coronary syndromes: a novel finding
Apelin is a novel endogenous peptide with inotropic and vasodilatory properties. To investigate the role of apelin in the prognosis of acute coronary syndromes (ACS) and to assess the relationship between apelin and other diagnostic and prognostic markers. Seventy-six patients with ACS (mean age 62....
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| Veröffentlicht in: | Kardiologia polska 2014-01, Vol.72 (3), p.239-245 |
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| container_title | Kardiologia polska |
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| creator | Cosansu, Kahraman Cakmak, Huseyin Altug Ikitimur, Baris Yildirim, Erkan Can, Gunay Karadag, Bilgehan Koldas, Lale |
| description | Apelin is a novel endogenous peptide with inotropic and vasodilatory properties.
To investigate the role of apelin in the prognosis of acute coronary syndromes (ACS) and to assess the relationship between apelin and other diagnostic and prognostic markers.
Seventy-six patients with ACS (mean age 62.1 ± 10 years) were evaluated in terms of their plasma apelin-36 concentrations, ejection fraction (EF), high sensitivity C-reactive protein (hsCRP), creatine kinase (CK), CK-MB and troponin I levels. The study group consisted of 35 ST elevation myocardial infarction (STEMI) and 41 non-ST elevation (NSTE) ACS patients. Patients were followed up for one year for cardiovascular outcomes.
There was no significant relationship between apelin and TIMI, GRACE, GENSINI scores, hsCRP and EF in STEMI and NSTE-ACS groups (p > 0.05). Apelin showed positive correlations with CK, CK-MB and troponin I in patients with NSTE-ACS, but a negative correlation in patients with STEMI (p < 0.05). There were no statistically significant differences between patients reaching the composite end point at one year with regard to apelin levels.
Apelin was positively correlated with cardiac biomarkers in patients with NSTE-ACS but negatively correlated in patients with STEMI. In STEMI, generally larger amounts of myocardial cells are subjected to infarction compared to NSTE-ACS, which may explain why apelin levels decrease with increasing CK, CK-MB and troponin levels in STEMI patients. |
| doi_str_mv | 10.5603/KP.a2013.0251 |
| format | Article |
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To investigate the role of apelin in the prognosis of acute coronary syndromes (ACS) and to assess the relationship between apelin and other diagnostic and prognostic markers.
Seventy-six patients with ACS (mean age 62.1 ± 10 years) were evaluated in terms of their plasma apelin-36 concentrations, ejection fraction (EF), high sensitivity C-reactive protein (hsCRP), creatine kinase (CK), CK-MB and troponin I levels. The study group consisted of 35 ST elevation myocardial infarction (STEMI) and 41 non-ST elevation (NSTE) ACS patients. Patients were followed up for one year for cardiovascular outcomes.
There was no significant relationship between apelin and TIMI, GRACE, GENSINI scores, hsCRP and EF in STEMI and NSTE-ACS groups (p > 0.05). Apelin showed positive correlations with CK, CK-MB and troponin I in patients with NSTE-ACS, but a negative correlation in patients with STEMI (p < 0.05). There were no statistically significant differences between patients reaching the composite end point at one year with regard to apelin levels.
Apelin was positively correlated with cardiac biomarkers in patients with NSTE-ACS but negatively correlated in patients with STEMI. In STEMI, generally larger amounts of myocardial cells are subjected to infarction compared to NSTE-ACS, which may explain why apelin levels decrease with increasing CK, CK-MB and troponin levels in STEMI patients.</description><identifier>ISSN: 0022-9032</identifier><identifier>EISSN: 1897-4279</identifier><identifier>DOI: 10.5603/KP.a2013.0251</identifier><identifier>PMID: 24142748</identifier><language>eng</language><publisher>Poland</publisher><subject>Aged ; Apelin ; Biomarkers - blood ; C-Reactive Protein - analysis ; Creatine Kinase - blood ; Creatine Kinase, MB Form - blood ; Female ; Humans ; Intercellular Signaling Peptides and Proteins - blood ; Male ; Middle Aged ; Myocardial Infarction - blood ; Myocardial Infarction - physiopathology ; Prognosis</subject><ispartof>Kardiologia polska, 2014-01, Vol.72 (3), p.239-245</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-90ae6a7e860f79330801e0c26e1b95a32266097fbdfe58220b30849f6f2d35653</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24142748$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cosansu, Kahraman</creatorcontrib><creatorcontrib>Cakmak, Huseyin Altug</creatorcontrib><creatorcontrib>Ikitimur, Baris</creatorcontrib><creatorcontrib>Yildirim, Erkan</creatorcontrib><creatorcontrib>Can, Gunay</creatorcontrib><creatorcontrib>Karadag, Bilgehan</creatorcontrib><creatorcontrib>Koldas, Lale</creatorcontrib><title>Apelin in ST segment elevation and non-ST segment elevation acute coronary syndromes: a novel finding</title><title>Kardiologia polska</title><addtitle>Kardiol Pol</addtitle><description>Apelin is a novel endogenous peptide with inotropic and vasodilatory properties.
To investigate the role of apelin in the prognosis of acute coronary syndromes (ACS) and to assess the relationship between apelin and other diagnostic and prognostic markers.
Seventy-six patients with ACS (mean age 62.1 ± 10 years) were evaluated in terms of their plasma apelin-36 concentrations, ejection fraction (EF), high sensitivity C-reactive protein (hsCRP), creatine kinase (CK), CK-MB and troponin I levels. The study group consisted of 35 ST elevation myocardial infarction (STEMI) and 41 non-ST elevation (NSTE) ACS patients. Patients were followed up for one year for cardiovascular outcomes.
There was no significant relationship between apelin and TIMI, GRACE, GENSINI scores, hsCRP and EF in STEMI and NSTE-ACS groups (p > 0.05). Apelin showed positive correlations with CK, CK-MB and troponin I in patients with NSTE-ACS, but a negative correlation in patients with STEMI (p < 0.05). There were no statistically significant differences between patients reaching the composite end point at one year with regard to apelin levels.
Apelin was positively correlated with cardiac biomarkers in patients with NSTE-ACS but negatively correlated in patients with STEMI. In STEMI, generally larger amounts of myocardial cells are subjected to infarction compared to NSTE-ACS, which may explain why apelin levels decrease with increasing CK, CK-MB and troponin levels in STEMI patients.</description><subject>Aged</subject><subject>Apelin</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - analysis</subject><subject>Creatine Kinase - blood</subject><subject>Creatine Kinase, MB Form - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Intercellular Signaling Peptides and Proteins - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Prognosis</subject><issn>0022-9032</issn><issn>1897-4279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1Lw0AQhhdRbK0evcr-gdTZ2WST9VaKX7RgwXoOm2S2RJJNyaaF_nu3Vj0JA8MwzwwvD2O3AqaJAnm_WE0NgpBTwEScsbHIdBrFmOpzNgZAjDRIHLEr7z_DmCkhLtkIYxGQOBszmm2pqR0P9b7mnjYtuYFTQ3sz1J3jxlXcdS76f1nuBuJl13fO9AfuD67qu5b8AzfhaE8Nt7Wrare5ZhfWNJ5ufvqEfTw9rucv0fLt-XU-W0allDiEqIaUSSlTYFMtJWQgCEpUJAqdGImoFOjUFpWlJEOEIiCxtspiJROVyAmLTn_LvvO-J5tv-7oN2XIB-VFXvljl37ryo67A35347a5oqfqjf_3IL8g5ZW8</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Cosansu, Kahraman</creator><creator>Cakmak, Huseyin Altug</creator><creator>Ikitimur, Baris</creator><creator>Yildirim, Erkan</creator><creator>Can, Gunay</creator><creator>Karadag, Bilgehan</creator><creator>Koldas, Lale</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20140101</creationdate><title>Apelin in ST segment elevation and non-ST segment elevation acute coronary syndromes: a novel finding</title><author>Cosansu, Kahraman ; Cakmak, Huseyin Altug ; Ikitimur, Baris ; Yildirim, Erkan ; Can, Gunay ; Karadag, Bilgehan ; Koldas, Lale</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-90ae6a7e860f79330801e0c26e1b95a32266097fbdfe58220b30849f6f2d35653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Apelin</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - analysis</topic><topic>Creatine Kinase - blood</topic><topic>Creatine Kinase, MB Form - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Intercellular Signaling Peptides and Proteins - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - blood</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Prognosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cosansu, Kahraman</creatorcontrib><creatorcontrib>Cakmak, Huseyin Altug</creatorcontrib><creatorcontrib>Ikitimur, Baris</creatorcontrib><creatorcontrib>Yildirim, Erkan</creatorcontrib><creatorcontrib>Can, Gunay</creatorcontrib><creatorcontrib>Karadag, Bilgehan</creatorcontrib><creatorcontrib>Koldas, Lale</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Kardiologia polska</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cosansu, Kahraman</au><au>Cakmak, Huseyin Altug</au><au>Ikitimur, Baris</au><au>Yildirim, Erkan</au><au>Can, Gunay</au><au>Karadag, Bilgehan</au><au>Koldas, Lale</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Apelin in ST segment elevation and non-ST segment elevation acute coronary syndromes: a novel finding</atitle><jtitle>Kardiologia polska</jtitle><addtitle>Kardiol Pol</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>72</volume><issue>3</issue><spage>239</spage><epage>245</epage><pages>239-245</pages><issn>0022-9032</issn><eissn>1897-4279</eissn><abstract>Apelin is a novel endogenous peptide with inotropic and vasodilatory properties.
To investigate the role of apelin in the prognosis of acute coronary syndromes (ACS) and to assess the relationship between apelin and other diagnostic and prognostic markers.
Seventy-six patients with ACS (mean age 62.1 ± 10 years) were evaluated in terms of their plasma apelin-36 concentrations, ejection fraction (EF), high sensitivity C-reactive protein (hsCRP), creatine kinase (CK), CK-MB and troponin I levels. The study group consisted of 35 ST elevation myocardial infarction (STEMI) and 41 non-ST elevation (NSTE) ACS patients. Patients were followed up for one year for cardiovascular outcomes.
There was no significant relationship between apelin and TIMI, GRACE, GENSINI scores, hsCRP and EF in STEMI and NSTE-ACS groups (p > 0.05). Apelin showed positive correlations with CK, CK-MB and troponin I in patients with NSTE-ACS, but a negative correlation in patients with STEMI (p < 0.05). There were no statistically significant differences between patients reaching the composite end point at one year with regard to apelin levels.
Apelin was positively correlated with cardiac biomarkers in patients with NSTE-ACS but negatively correlated in patients with STEMI. In STEMI, generally larger amounts of myocardial cells are subjected to infarction compared to NSTE-ACS, which may explain why apelin levels decrease with increasing CK, CK-MB and troponin levels in STEMI patients.</abstract><cop>Poland</cop><pmid>24142748</pmid><doi>10.5603/KP.a2013.0251</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Kardiologia polska, 2014-01, Vol.72 (3), p.239-245 |
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| language | eng |
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| source | MEDLINE; EZB Electronic Journals Library |
| subjects | Aged Apelin Biomarkers - blood C-Reactive Protein - analysis Creatine Kinase - blood Creatine Kinase, MB Form - blood Female Humans Intercellular Signaling Peptides and Proteins - blood Male Middle Aged Myocardial Infarction - blood Myocardial Infarction - physiopathology Prognosis |
| title | Apelin in ST segment elevation and non-ST segment elevation acute coronary syndromes: a novel finding |
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