Extra-pulmonary tuberculosis: differential aspects and role of 16S-rRNA in urine
BACKGROUND: Early diagnosis of extra-pulmonary tuberculosis (EPTB) is important for successful treatment. METHODS: All cases of EPTB diagnosed at Ramon y Cajal Hospital, Madrid, Spain, from 1997 to 2008 were analysed and compared with pulmonary tuberculosis (PTB) patients to identify differential pa...
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| creator | Fortún, J. Martín-Dávila, P. Gómez-Mampaso, E. González-García, A. Barbolla, I. Gómez-García, I. Wikman, P. Ortíz, J. Navas, E. Cuartero, C. Gijón, D. Moreno, S. |
| description | BACKGROUND: Early diagnosis of extra-pulmonary tuberculosis (EPTB) is important for successful treatment. METHODS: All cases of EPTB diagnosed at Ramon y
Cajal Hospital, Madrid, Spain, from 1997 to 2008 were analysed and compared with pulmonary tuberculosis (PTB) patients to identify differential parameters that could serve to predict the presence of EPTB at initial presentation. Different microbiological techniques were analysed, including
amplification of 16S-rRNA in urine. RESULTS: During the study period, 814 cases of TB were diagnosed at our centre; 330 (40.5%) were EPTB. Concomitant PTB was detected in 45% of EPTB cases. The main clinical forms of
EPTB were lymphadenitis (86, 26%), miliary TB (60, 18%), and multifocal TB (43, 13%). Variables independently associated with EPTB were human immunodeficiency virus (HIV) infection (OR 3.6, 95%CI 2.4-5.4), older age (>60 years) (OR 3.7, 95%CI 2.5-5.6) and mortality (OR 2.9,
95%CI 1.3-6.3). 16S-rRNA in urine was performed in 82 EPTB patients (25%), among whom a positive result was obtained in 70%; in the PTB group, a positive result was found in 5 of 28 patients (18%) (P |
| doi_str_mv | 10.5588/ijtld.13.0555 |
| format | Article |
| fullrecord | <record><control><sourceid>pubtec_cross</sourceid><recordid>TN_cdi_crossref_primary_10_5588_ijtld_13_0555</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ingid>iuatld/ijtld/2014/00000018/00000004/art00019</ingid><sourcerecordid>iuatld/ijtld/2014/00000018/00000004/art00019</sourcerecordid><originalsourceid>FETCH-LOGICAL-c491t-52e20cbd62352b96cbd394a9fc2ed4e3a26b5bc1618e63d89d9f102873388e1b3</originalsourceid><addsrcrecordid>eNqNkUmLFTEURgtR7EGXbqU2gpt65maoStw13W0rNM6uL6lUqskjL_XMIOqvN29QV4LZ5BIOX7jna5onQFZCSPnCrbOfVsBWRAhxrzkFCaIbFCX360zo0LEB1ElzltKaEAoAw8PmhPJ-IAPpT5v3199z1N22-M0SdPzR5jLaaIpfkksv28nNs402ZKd9q9PWmpxaHaY2Lt62y9xC_6mLH99etC60JbpgHzUPZu2TfXy8z5svr64_X77ubt_dvLm8uO0MV5A7QS0lZpx6ygQdVV9HprhWs6F24pZp2o9iNNCDtD2bpJrUXNeRA2NSWhjZefP8kLuNy9diU8aNS8Z6r4NdSkIQAmo4GeR_oABMDYqxinYH1MQlpWhn3Ea3qV4QCO584943AsOd78o_PUaXcWOnP_RvwRV4dgR0MtrPUQfj0l9OcqJ4D5X7cOBcuKu6Na6XEkMViM6gK3r_aa1z1yZ-Axk40lonkVQgcCFxsrMuPmPWEe9-YgJVM6_-lXkIPOxCCXAk-wPyOBCOOubdi2K_ACovuRA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1511397933</pqid></control><display><type>article</type><title>Extra-pulmonary tuberculosis: differential aspects and role of 16S-rRNA in urine</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Fortún, J. ; Martín-Dávila, P. ; Gómez-Mampaso, E. ; González-García, A. ; Barbolla, I. ; Gómez-García, I. ; Wikman, P. ; Ortíz, J. ; Navas, E. ; Cuartero, C. ; Gijón, D. ; Moreno, S.</creator><creatorcontrib>Fortún, J. ; Martín-Dávila, P. ; Gómez-Mampaso, E. ; González-García, A. ; Barbolla, I. ; Gómez-García, I. ; Wikman, P. ; Ortíz, J. ; Navas, E. ; Cuartero, C. ; Gijón, D. ; Moreno, S.</creatorcontrib><description>BACKGROUND: Early diagnosis of extra-pulmonary tuberculosis (EPTB) is important for successful treatment. METHODS: All cases of EPTB diagnosed at Ramon y
Cajal Hospital, Madrid, Spain, from 1997 to 2008 were analysed and compared with pulmonary tuberculosis (PTB) patients to identify differential parameters that could serve to predict the presence of EPTB at initial presentation. Different microbiological techniques were analysed, including
amplification of 16S-rRNA in urine. RESULTS: During the study period, 814 cases of TB were diagnosed at our centre; 330 (40.5%) were EPTB. Concomitant PTB was detected in 45% of EPTB cases. The main clinical forms of
EPTB were lymphadenitis (86, 26%), miliary TB (60, 18%), and multifocal TB (43, 13%). Variables independently associated with EPTB were human immunodeficiency virus (HIV) infection (OR 3.6, 95%CI 2.4-5.4), older age (>60 years) (OR 3.7, 95%CI 2.5-5.6) and mortality (OR 2.9,
95%CI 1.3-6.3). 16S-rRNA in urine was performed in 82 EPTB patients (25%), among whom a positive result was obtained in 70%; in the PTB group, a positive result was found in 5 of 28 patients (18%) (P <0.001).CONCLUSIONS: HIV infection and older age appear to be the main risk factors associated with EPTB. In this study, mortality was significantly higher in patients with EPTB. A positive 16S-rRNA test result in urine is a useful marker of EPTB.</description><identifier>ISSN: 1027-3719</identifier><identifier>EISSN: 1815-7920</identifier><identifier>DOI: 10.5588/ijtld.13.0555</identifier><identifier>PMID: 24670706</identifier><language>eng</language><publisher>Paris: International Union Against Tuberculosis and Lung Disease</publisher><subject>Adult ; Age Factors ; Aged ; Bacterial diseases ; Biological and medical sciences ; Chi-Square Distribution ; Comorbidity ; Extra-Pulmonary ; Female ; Genetic Markers ; HIV Infections - epidemiology ; Human bacterial diseases ; Human immunodeficiency virus ; Humans ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Mycobacterium ; Mycobacterium tuberculosis - genetics ; Odds Ratio ; PCR ; Pneumology ; Predictive Value of Tests ; Risk Factors ; RNA, Bacterial - urine ; RNA, Ribosomal, 16S - urine ; Spain ; Tuberculosis ; Tuberculosis - diagnosis ; Tuberculosis - microbiology ; Tuberculosis - mortality ; Tuberculosis - urine ; Tuberculosis and atypical mycobacterial infections ; Tuberculosis, Pulmonary - diagnosis ; Tuberculosis, Pulmonary - microbiology ; Tuberculosis, Pulmonary - urine ; Urine</subject><ispartof>The international journal of tuberculosis and lung disease, 2014-04, Vol.18 (4), p.478-485</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-52e20cbd62352b96cbd394a9fc2ed4e3a26b5bc1618e63d89d9f102873388e1b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28409461$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24670706$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fortún, J.</creatorcontrib><creatorcontrib>Martín-Dávila, P.</creatorcontrib><creatorcontrib>Gómez-Mampaso, E.</creatorcontrib><creatorcontrib>González-García, A.</creatorcontrib><creatorcontrib>Barbolla, I.</creatorcontrib><creatorcontrib>Gómez-García, I.</creatorcontrib><creatorcontrib>Wikman, P.</creatorcontrib><creatorcontrib>Ortíz, J.</creatorcontrib><creatorcontrib>Navas, E.</creatorcontrib><creatorcontrib>Cuartero, C.</creatorcontrib><creatorcontrib>Gijón, D.</creatorcontrib><creatorcontrib>Moreno, S.</creatorcontrib><title>Extra-pulmonary tuberculosis: differential aspects and role of 16S-rRNA in urine</title><title>The international journal of tuberculosis and lung disease</title><addtitle>Int J Tuberc Lung Dis</addtitle><description>BACKGROUND: Early diagnosis of extra-pulmonary tuberculosis (EPTB) is important for successful treatment. METHODS: All cases of EPTB diagnosed at Ramon y
Cajal Hospital, Madrid, Spain, from 1997 to 2008 were analysed and compared with pulmonary tuberculosis (PTB) patients to identify differential parameters that could serve to predict the presence of EPTB at initial presentation. Different microbiological techniques were analysed, including
amplification of 16S-rRNA in urine. RESULTS: During the study period, 814 cases of TB were diagnosed at our centre; 330 (40.5%) were EPTB. Concomitant PTB was detected in 45% of EPTB cases. The main clinical forms of
EPTB were lymphadenitis (86, 26%), miliary TB (60, 18%), and multifocal TB (43, 13%). Variables independently associated with EPTB were human immunodeficiency virus (HIV) infection (OR 3.6, 95%CI 2.4-5.4), older age (>60 years) (OR 3.7, 95%CI 2.5-5.6) and mortality (OR 2.9,
95%CI 1.3-6.3). 16S-rRNA in urine was performed in 82 EPTB patients (25%), among whom a positive result was obtained in 70%; in the PTB group, a positive result was found in 5 of 28 patients (18%) (P <0.001).CONCLUSIONS: HIV infection and older age appear to be the main risk factors associated with EPTB. In this study, mortality was significantly higher in patients with EPTB. A positive 16S-rRNA test result in urine is a useful marker of EPTB.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Chi-Square Distribution</subject><subject>Comorbidity</subject><subject>Extra-Pulmonary</subject><subject>Female</subject><subject>Genetic Markers</subject><subject>HIV Infections - epidemiology</subject><subject>Human bacterial diseases</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Mycobacterium</subject><subject>Mycobacterium tuberculosis - genetics</subject><subject>Odds Ratio</subject><subject>PCR</subject><subject>Pneumology</subject><subject>Predictive Value of Tests</subject><subject>Risk Factors</subject><subject>RNA, Bacterial - urine</subject><subject>RNA, Ribosomal, 16S - urine</subject><subject>Spain</subject><subject>Tuberculosis</subject><subject>Tuberculosis - diagnosis</subject><subject>Tuberculosis - microbiology</subject><subject>Tuberculosis - mortality</subject><subject>Tuberculosis - urine</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><subject>Tuberculosis, Pulmonary - diagnosis</subject><subject>Tuberculosis, Pulmonary - microbiology</subject><subject>Tuberculosis, Pulmonary - urine</subject><subject>Urine</subject><issn>1027-3719</issn><issn>1815-7920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUmLFTEURgtR7EGXbqU2gpt65maoStw13W0rNM6uL6lUqskjL_XMIOqvN29QV4LZ5BIOX7jna5onQFZCSPnCrbOfVsBWRAhxrzkFCaIbFCX360zo0LEB1ElzltKaEAoAw8PmhPJ-IAPpT5v3199z1N22-M0SdPzR5jLaaIpfkksv28nNs402ZKd9q9PWmpxaHaY2Lt62y9xC_6mLH99etC60JbpgHzUPZu2TfXy8z5svr64_X77ubt_dvLm8uO0MV5A7QS0lZpx6ygQdVV9HprhWs6F24pZp2o9iNNCDtD2bpJrUXNeRA2NSWhjZefP8kLuNy9diU8aNS8Z6r4NdSkIQAmo4GeR_oABMDYqxinYH1MQlpWhn3Ea3qV4QCO584943AsOd78o_PUaXcWOnP_RvwRV4dgR0MtrPUQfj0l9OcqJ4D5X7cOBcuKu6Na6XEkMViM6gK3r_aa1z1yZ-Axk40lonkVQgcCFxsrMuPmPWEe9-YgJVM6_-lXkIPOxCCXAk-wPyOBCOOubdi2K_ACovuRA</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Fortún, J.</creator><creator>Martín-Dávila, P.</creator><creator>Gómez-Mampaso, E.</creator><creator>González-García, A.</creator><creator>Barbolla, I.</creator><creator>Gómez-García, I.</creator><creator>Wikman, P.</creator><creator>Ortíz, J.</creator><creator>Navas, E.</creator><creator>Cuartero, C.</creator><creator>Gijón, D.</creator><creator>Moreno, S.</creator><general>International Union Against Tuberculosis and Lung Disease</general><general>International Union against Tuberculosis and Lung Disease</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20140401</creationdate><title>Extra-pulmonary tuberculosis: differential aspects and role of 16S-rRNA in urine</title><author>Fortún, J. ; Martín-Dávila, P. ; Gómez-Mampaso, E. ; González-García, A. ; Barbolla, I. ; Gómez-García, I. ; Wikman, P. ; Ortíz, J. ; Navas, E. ; Cuartero, C. ; Gijón, D. ; Moreno, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-52e20cbd62352b96cbd394a9fc2ed4e3a26b5bc1618e63d89d9f102873388e1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Chi-Square Distribution</topic><topic>Comorbidity</topic><topic>Extra-Pulmonary</topic><topic>Female</topic><topic>Genetic Markers</topic><topic>HIV Infections - epidemiology</topic><topic>Human bacterial diseases</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Mycobacterium</topic><topic>Mycobacterium tuberculosis - genetics</topic><topic>Odds Ratio</topic><topic>PCR</topic><topic>Pneumology</topic><topic>Predictive Value of Tests</topic><topic>Risk Factors</topic><topic>RNA, Bacterial - urine</topic><topic>RNA, Ribosomal, 16S - urine</topic><topic>Spain</topic><topic>Tuberculosis</topic><topic>Tuberculosis - diagnosis</topic><topic>Tuberculosis - microbiology</topic><topic>Tuberculosis - mortality</topic><topic>Tuberculosis - urine</topic><topic>Tuberculosis and atypical mycobacterial infections</topic><topic>Tuberculosis, Pulmonary - diagnosis</topic><topic>Tuberculosis, Pulmonary - microbiology</topic><topic>Tuberculosis, Pulmonary - urine</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fortún, J.</creatorcontrib><creatorcontrib>Martín-Dávila, P.</creatorcontrib><creatorcontrib>Gómez-Mampaso, E.</creatorcontrib><creatorcontrib>González-García, A.</creatorcontrib><creatorcontrib>Barbolla, I.</creatorcontrib><creatorcontrib>Gómez-García, I.</creatorcontrib><creatorcontrib>Wikman, P.</creatorcontrib><creatorcontrib>Ortíz, J.</creatorcontrib><creatorcontrib>Navas, E.</creatorcontrib><creatorcontrib>Cuartero, C.</creatorcontrib><creatorcontrib>Gijón, D.</creatorcontrib><creatorcontrib>Moreno, S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>The international journal of tuberculosis and lung disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fortún, J.</au><au>Martín-Dávila, P.</au><au>Gómez-Mampaso, E.</au><au>González-García, A.</au><au>Barbolla, I.</au><au>Gómez-García, I.</au><au>Wikman, P.</au><au>Ortíz, J.</au><au>Navas, E.</au><au>Cuartero, C.</au><au>Gijón, D.</au><au>Moreno, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extra-pulmonary tuberculosis: differential aspects and role of 16S-rRNA in urine</atitle><jtitle>The international journal of tuberculosis and lung disease</jtitle><addtitle>Int J Tuberc Lung Dis</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>18</volume><issue>4</issue><spage>478</spage><epage>485</epage><pages>478-485</pages><issn>1027-3719</issn><eissn>1815-7920</eissn><abstract>BACKGROUND: Early diagnosis of extra-pulmonary tuberculosis (EPTB) is important for successful treatment. METHODS: All cases of EPTB diagnosed at Ramon y
Cajal Hospital, Madrid, Spain, from 1997 to 2008 were analysed and compared with pulmonary tuberculosis (PTB) patients to identify differential parameters that could serve to predict the presence of EPTB at initial presentation. Different microbiological techniques were analysed, including
amplification of 16S-rRNA in urine. RESULTS: During the study period, 814 cases of TB were diagnosed at our centre; 330 (40.5%) were EPTB. Concomitant PTB was detected in 45% of EPTB cases. The main clinical forms of
EPTB were lymphadenitis (86, 26%), miliary TB (60, 18%), and multifocal TB (43, 13%). Variables independently associated with EPTB were human immunodeficiency virus (HIV) infection (OR 3.6, 95%CI 2.4-5.4), older age (>60 years) (OR 3.7, 95%CI 2.5-5.6) and mortality (OR 2.9,
95%CI 1.3-6.3). 16S-rRNA in urine was performed in 82 EPTB patients (25%), among whom a positive result was obtained in 70%; in the PTB group, a positive result was found in 5 of 28 patients (18%) (P <0.001).CONCLUSIONS: HIV infection and older age appear to be the main risk factors associated with EPTB. In this study, mortality was significantly higher in patients with EPTB. A positive 16S-rRNA test result in urine is a useful marker of EPTB.</abstract><cop>Paris</cop><pub>International Union Against Tuberculosis and Lung Disease</pub><pmid>24670706</pmid><doi>10.5588/ijtld.13.0555</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Age Factors Aged Bacterial diseases Biological and medical sciences Chi-Square Distribution Comorbidity Extra-Pulmonary Female Genetic Markers HIV Infections - epidemiology Human bacterial diseases Human immunodeficiency virus Humans Infectious diseases Male Medical sciences Middle Aged Multivariate Analysis Mycobacterium Mycobacterium tuberculosis - genetics Odds Ratio PCR Pneumology Predictive Value of Tests Risk Factors RNA, Bacterial - urine RNA, Ribosomal, 16S - urine Spain Tuberculosis Tuberculosis - diagnosis Tuberculosis - microbiology Tuberculosis - mortality Tuberculosis - urine Tuberculosis and atypical mycobacterial infections Tuberculosis, Pulmonary - diagnosis Tuberculosis, Pulmonary - microbiology Tuberculosis, Pulmonary - urine Urine |
| title | Extra-pulmonary tuberculosis: differential aspects and role of 16S-rRNA in urine |
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