Ezh1 regulates expression of Cpg15/Neuritin in mouse cortical neurons
Immature neurons undergo morphological and physiological maturation in order to establish neuronal networks. During neuronal maturation, a large number of genes change their transcriptional levels, and these changes may be mediated by chromatin modifiers. In this study, we found that the level of Ez...
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| Veröffentlicht in: | Drug Discoveries & Therapeutics 2021/04/30, Vol.15(2), pp.55-65 |
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| container_title | Drug Discoveries & Therapeutics |
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| creator | Utsunomiya, Shun Kishi, Yusuke Tsuboi, Masafumi Kawaguchi, Daichi Gotoh, Yukiko Abe, Manabu Sakimura, Kenji Maeda, Kazuma Takemoto, Hiroshi |
| description | Immature neurons undergo morphological and physiological maturation in order to establish neuronal networks. During neuronal maturation, a large number of genes change their transcriptional levels, and these changes may be mediated by chromatin modifiers. In this study, we found that the level of Ezh1, a component of Polycomb repressive complex 2 (PRC2), increases during neuronal maturation in mouse neocortical culture. In addition, conditional knockout of Ezh1 in post-mitotic excitatory neurons leads to downregulation of a set of genes related to neuronal maturation. Moreover, the locus encoding Cpg15/Neuritin (Nrn1), which is regulated by neuronal activity and implicated in stabilization and maturation of excitatory synapses, is a direct target of Ezh1 in cortical neurons. Together, these results suggest that elevated expression of Ezh1 contributes to maturation of cortical neurons. |
| doi_str_mv | 10.5582/ddt.2021.01017 |
| format | Article |
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During neuronal maturation, a large number of genes change their transcriptional levels, and these changes may be mediated by chromatin modifiers. In this study, we found that the level of Ezh1, a component of Polycomb repressive complex 2 (PRC2), increases during neuronal maturation in mouse neocortical culture. In addition, conditional knockout of Ezh1 in post-mitotic excitatory neurons leads to downregulation of a set of genes related to neuronal maturation. Moreover, the locus encoding Cpg15/Neuritin (Nrn1), which is regulated by neuronal activity and implicated in stabilization and maturation of excitatory synapses, is a direct target of Ezh1 in cortical neurons. 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During neuronal maturation, a large number of genes change their transcriptional levels, and these changes may be mediated by chromatin modifiers. In this study, we found that the level of Ezh1, a component of Polycomb repressive complex 2 (PRC2), increases during neuronal maturation in mouse neocortical culture. In addition, conditional knockout of Ezh1 in post-mitotic excitatory neurons leads to downregulation of a set of genes related to neuronal maturation. Moreover, the locus encoding Cpg15/Neuritin (Nrn1), which is regulated by neuronal activity and implicated in stabilization and maturation of excitatory synapses, is a direct target of Ezh1 in cortical neurons. 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| source | J-STAGE Free; EZB-FREE-00999 freely available EZB journals |
| subjects | Alzheimer's disease depression epigenetics neuronal maturation Nrn1 Polycomb group proteins |
| title | Ezh1 regulates expression of Cpg15/Neuritin in mouse cortical neurons |
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