Alterations of GABAB binding caused by acute and chronic lead administration
The effect of lead on GABAB binding was studied on membranes obtained from acute and chronically lead-treated rats. Acute lead treatment reduced both GABAB affinity (KD) by about 30% and density of receptor (Bmax) by about 15%. On the contrary chronic lead treatment increased receptor capacity by ab...
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| Veröffentlicht in: | Acta neurobiologiae experimentalis 1996, Vol.56 (1), p.227-231 |
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| container_title | Acta neurobiologiae experimentalis |
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| creator | Waśkiewicz, J |
| description | The effect of lead on GABAB binding was studied on membranes obtained from acute and chronically lead-treated rats. Acute lead treatment reduced both GABAB affinity (KD) by about 30% and density of receptor (Bmax) by about 15%. On the contrary chronic lead treatment increased receptor capacity by about 20% in spite of decreased receptor affinity by 25%. Both acute and chronic lead treatment shiffted displacement curves toward higher concentration of non-labelled compound (decreased affinity). The results show that lead can affect the GABAB binding in two ways: by reducing affinity of binding and by altering capacity of binding. |
| doi_str_mv | 10.55782/ane-1996-1124 |
| format | Article |
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Acute lead treatment reduced both GABAB affinity (KD) by about 30% and density of receptor (Bmax) by about 15%. On the contrary chronic lead treatment increased receptor capacity by about 20% in spite of decreased receptor affinity by 25%. Both acute and chronic lead treatment shiffted displacement curves toward higher concentration of non-labelled compound (decreased affinity). The results show that lead can affect the GABAB binding in two ways: by reducing affinity of binding and by altering capacity of binding.</description><identifier>ISSN: 0065-1400</identifier><identifier>EISSN: 1689-0035</identifier><identifier>DOI: 10.55782/ane-1996-1124</identifier><identifier>PMID: 8787178</identifier><language>eng</language><publisher>Poland</publisher><subject>Animals ; Brain Chemistry - drug effects ; In Vitro Techniques ; Kinetics ; Lead - toxicity ; Male ; Rats ; Rats, Wistar ; Receptors, GABA-B - drug effects ; Receptors, GABA-B - metabolism ; Synaptosomes - metabolism</subject><ispartof>Acta neurobiologiae experimentalis, 1996, Vol.56 (1), p.227-231</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c205t-ad5d9413caeb8465185309f7ba8faaa9ecf891477456ee3213a7a8093e2774293</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8787178$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Waśkiewicz, J</creatorcontrib><title>Alterations of GABAB binding caused by acute and chronic lead administration</title><title>Acta neurobiologiae experimentalis</title><addtitle>Acta Neurobiol Exp (Wars)</addtitle><description>The effect of lead on GABAB binding was studied on membranes obtained from acute and chronically lead-treated rats. Acute lead treatment reduced both GABAB affinity (KD) by about 30% and density of receptor (Bmax) by about 15%. On the contrary chronic lead treatment increased receptor capacity by about 20% in spite of decreased receptor affinity by 25%. Both acute and chronic lead treatment shiffted displacement curves toward higher concentration of non-labelled compound (decreased affinity). The results show that lead can affect the GABAB binding in two ways: by reducing affinity of binding and by altering capacity of binding.</description><subject>Animals</subject><subject>Brain Chemistry - drug effects</subject><subject>In Vitro Techniques</subject><subject>Kinetics</subject><subject>Lead - toxicity</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, GABA-B - drug effects</subject><subject>Receptors, GABA-B - metabolism</subject><subject>Synaptosomes - metabolism</subject><issn>0065-1400</issn><issn>1689-0035</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90DtPwzAUBWALgUoprGxI_gMu16_YHtOKl1SJBeboxnbAqHWqOB3672lpxXSXe46OPkLuOcy1NlY8Yo6MO1cxzoW6IFNeWccApL4kU4BKM64ArslNKT8AwhgBEzKxxhpu7JSs6vUYBxxTnwvtO_pSL-oFbVMOKX9Rj7sSA233FP1ujBRzoP576HPydB0xUAyblFMZTw235KrDdYl35zsjn89PH8tXtnp_eVvWK-YF6JFh0MEpLj3G1qpKc6sluM60aDtEdNF31nFljNJVjFJwiQYtOBkP85Vwckbmp14_9KUMsWu2Q9rgsG84NH8qzUGlOao0R5VD4OEU2O7aTQz_72cG-Qv04F0I</recordid><startdate>1996</startdate><enddate>1996</enddate><creator>Waśkiewicz, J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1996</creationdate><title>Alterations of GABAB binding caused by acute and chronic lead administration</title><author>Waśkiewicz, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c205t-ad5d9413caeb8465185309f7ba8faaa9ecf891477456ee3213a7a8093e2774293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Brain Chemistry - drug effects</topic><topic>In Vitro Techniques</topic><topic>Kinetics</topic><topic>Lead - toxicity</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, GABA-B - drug effects</topic><topic>Receptors, GABA-B - metabolism</topic><topic>Synaptosomes - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Waśkiewicz, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Acta neurobiologiae experimentalis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Waśkiewicz, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alterations of GABAB binding caused by acute and chronic lead administration</atitle><jtitle>Acta neurobiologiae experimentalis</jtitle><addtitle>Acta Neurobiol Exp (Wars)</addtitle><date>1996</date><risdate>1996</risdate><volume>56</volume><issue>1</issue><spage>227</spage><epage>231</epage><pages>227-231</pages><issn>0065-1400</issn><eissn>1689-0035</eissn><abstract>The effect of lead on GABAB binding was studied on membranes obtained from acute and chronically lead-treated rats. Acute lead treatment reduced both GABAB affinity (KD) by about 30% and density of receptor (Bmax) by about 15%. On the contrary chronic lead treatment increased receptor capacity by about 20% in spite of decreased receptor affinity by 25%. Both acute and chronic lead treatment shiffted displacement curves toward higher concentration of non-labelled compound (decreased affinity). The results show that lead can affect the GABAB binding in two ways: by reducing affinity of binding and by altering capacity of binding.</abstract><cop>Poland</cop><pmid>8787178</pmid><doi>10.55782/ane-1996-1124</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0065-1400 |
| ispartof | Acta neurobiologiae experimentalis, 1996, Vol.56 (1), p.227-231 |
| issn | 0065-1400 1689-0035 |
| language | eng |
| recordid | cdi_crossref_primary_10_55782_ane_1996_1124 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Brain Chemistry - drug effects In Vitro Techniques Kinetics Lead - toxicity Male Rats Rats, Wistar Receptors, GABA-B - drug effects Receptors, GABA-B - metabolism Synaptosomes - metabolism |
| title | Alterations of GABAB binding caused by acute and chronic lead administration |
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