In Vitro Activity of Biometal(II) Complexes of Monensin Against Virus-Induced Transplantable Animal Tumors
The anticancer properties of monensic acid (MonH) and its complexes with ions of Mg(II), Ca(II), Mn(II) and Co(II) were studied in cultured permanent cell lines originated from virus-induced transplantable tumors in chicken (hepatoma, LSCC-SF-Mc29) and in rat (sarcoma, LSR-SF-SR). The short-term exp...
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| Veröffentlicht in: | Biotechnology, biotechnological equipment biotechnological equipment, 2013, Vol.27 (2), p.3703-3708 |
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| creator | Pantcheva, Ivayla Alexandrova, Radostina Zhivkova, Tanya Mitewa, Mariana |
| description | The anticancer properties of monensic acid (MonH) and its complexes with ions of Mg(II), Ca(II), Mn(II) and Co(II) were studied in cultured permanent cell lines originated from virus-induced transplantable tumors in chicken (hepatoma, LSCC-SF-Mc29) and in rat (sarcoma, LSR-SF-SR). The short-term experiments in monolayer adherent cells were performed by thiazolyl blue tetrazolium bromide (MTT) test (hepatoma and sarcoma cell lines) and neutral red (NR) uptake cytotoxicity assay (sarcoma cell line). The effect of monensin and corresponding complexes on the colony-forming ability of tumor cells was also evaluated. From the results obtained it can be concluded that all compounds significantly decrease the viability and proliferation of the treated cells in a time- and concentration-dependent manner, with metal(II) complexes being more effective than the non-coordinated ligand. |
| doi_str_mv | 10.5504/BBEQ.2012.0088 |
| format | Article |
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The short-term experiments in monolayer adherent cells were performed by thiazolyl blue tetrazolium bromide (MTT) test (hepatoma and sarcoma cell lines) and neutral red (NR) uptake cytotoxicity assay (sarcoma cell line). The effect of monensin and corresponding complexes on the colony-forming ability of tumor cells was also evaluated. From the results obtained it can be concluded that all compounds significantly decrease the viability and proliferation of the treated cells in a time- and concentration-dependent manner, with metal(II) complexes being more effective than the non-coordinated ligand.</description><identifier>ISSN: 1310-2818</identifier><identifier>EISSN: 1314-3530</identifier><identifier>DOI: 10.5504/BBEQ.2012.0088</identifier><language>eng</language><publisher>Sofia: Taylor & Francis</publisher><subject>Adherent cells ; Anticancer properties ; Biotechnology ; Cell proliferation ; Coordination compounds ; cytotoxic/antiproliferative effects ; Cytotoxicity ; Hepatoma ; Magnesium ; Manganese ; Metal concentrations ; Monensin ; monensin biometal(II) complexes ; Poultry ; Sarcoma ; Time dependence ; Toxicity ; Tumor cell lines ; Tumor cells ; Tumors ; Virus-transformed chicken/rat tumor cells ; Viruses</subject><ispartof>Biotechnology, biotechnological equipment, 2013, Vol.27 (2), p.3703-3708</ispartof><rights>2013 Taylor and Francis Group, LLC 2013</rights><rights>2013 Taylor and Francis Group, LLC</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-8f1ce9f166ee5781a2541b967ef0157896f929c3ba894b31538b1a135f087cb3</citedby><cites>FETCH-LOGICAL-c350t-8f1ce9f166ee5781a2541b967ef0157896f929c3ba894b31538b1a135f087cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids></links><search><creatorcontrib>Pantcheva, Ivayla</creatorcontrib><creatorcontrib>Alexandrova, Radostina</creatorcontrib><creatorcontrib>Zhivkova, Tanya</creatorcontrib><creatorcontrib>Mitewa, Mariana</creatorcontrib><title>In Vitro Activity of Biometal(II) Complexes of Monensin Against Virus-Induced Transplantable Animal Tumors</title><title>Biotechnology, biotechnological equipment</title><description>The anticancer properties of monensic acid (MonH) and its complexes with ions of Mg(II), Ca(II), Mn(II) and Co(II) were studied in cultured permanent cell lines originated from virus-induced transplantable tumors in chicken (hepatoma, LSCC-SF-Mc29) and in rat (sarcoma, LSR-SF-SR). The short-term experiments in monolayer adherent cells were performed by thiazolyl blue tetrazolium bromide (MTT) test (hepatoma and sarcoma cell lines) and neutral red (NR) uptake cytotoxicity assay (sarcoma cell line). The effect of monensin and corresponding complexes on the colony-forming ability of tumor cells was also evaluated. From the results obtained it can be concluded that all compounds significantly decrease the viability and proliferation of the treated cells in a time- and concentration-dependent manner, with metal(II) complexes being more effective than the non-coordinated ligand.</description><subject>Adherent cells</subject><subject>Anticancer properties</subject><subject>Biotechnology</subject><subject>Cell proliferation</subject><subject>Coordination compounds</subject><subject>cytotoxic/antiproliferative effects</subject><subject>Cytotoxicity</subject><subject>Hepatoma</subject><subject>Magnesium</subject><subject>Manganese</subject><subject>Metal concentrations</subject><subject>Monensin</subject><subject>monensin biometal(II) complexes</subject><subject>Poultry</subject><subject>Sarcoma</subject><subject>Time dependence</subject><subject>Toxicity</subject><subject>Tumor cell lines</subject><subject>Tumor cells</subject><subject>Tumors</subject><subject>Virus-transformed chicken/rat tumor cells</subject><subject>Viruses</subject><issn>1310-2818</issn><issn>1314-3530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kEGLFDEQhRtRcF29eg54WQ89VpJOd3KcGVZtWBFh8BrSmUQypJMxSbvOvzfteFrwVEXVe8Wrr2neYtgwBt2H3e7-24YAJhsAzp81N5jirqWMwvO_PbSEY_6yeZXzCWAAwMNNcxoD-u5Kimiri_vlygVFi3YuzqYofzeO79E-zmdvfpu8br7EYEJ2AW1_KBdyqea05HYMx0WbIzokFfLZq1DU5A3aBjcrjw7LHFN-3bywymfz5l-9bQ4f7w_7z-3D10_jfvvQasqgtNxibYTFfW8MGzhWhHV4Ev1gLOA6EL0VRGg6KS66iWJG-YQVpswCH_REb5u769lzij8Xk4ucXdbG11AmLlliOhBgAnpepe-eSE9xSaGGk4QQ0Xc9EbSqNleVTjHnZKw8p_pWukgMciUvV_JyJS9X8tUgrgYXbEyzeozJH2VRFx-TrYC0y5L-x_sHEjCH3Q</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Pantcheva, Ivayla</creator><creator>Alexandrova, Radostina</creator><creator>Zhivkova, Tanya</creator><creator>Mitewa, Mariana</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7ST</scope><scope>7XB</scope><scope>8FD</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>SOI</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>2013</creationdate><title>In Vitro Activity of Biometal(II) Complexes of Monensin Against Virus-Induced Transplantable Animal Tumors</title><author>Pantcheva, Ivayla ; 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The short-term experiments in monolayer adherent cells were performed by thiazolyl blue tetrazolium bromide (MTT) test (hepatoma and sarcoma cell lines) and neutral red (NR) uptake cytotoxicity assay (sarcoma cell line). The effect of monensin and corresponding complexes on the colony-forming ability of tumor cells was also evaluated. From the results obtained it can be concluded that all compounds significantly decrease the viability and proliferation of the treated cells in a time- and concentration-dependent manner, with metal(II) complexes being more effective than the non-coordinated ligand.</abstract><cop>Sofia</cop><pub>Taylor & Francis</pub><doi>10.5504/BBEQ.2012.0088</doi><tpages>6</tpages></addata></record> |
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| subjects | Adherent cells Anticancer properties Biotechnology Cell proliferation Coordination compounds cytotoxic/antiproliferative effects Cytotoxicity Hepatoma Magnesium Manganese Metal concentrations Monensin monensin biometal(II) complexes Poultry Sarcoma Time dependence Toxicity Tumor cell lines Tumor cells Tumors Virus-transformed chicken/rat tumor cells Viruses |
| title | In Vitro Activity of Biometal(II) Complexes of Monensin Against Virus-Induced Transplantable Animal Tumors |
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