Retinal Structural Changes in Systemic Arterial Hypertension: An OCT Study

Purpose To assess retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), and macular thickness changes in young adults with systemic arterial hypertension. Methods This study included 80 young patients (age 23.8 ± 2.8 years) with systemic hypertension (sHT) without any known systemic or ocul...

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Veröffentlicht in:European journal of ophthalmology 2016-09, Vol.26 (5), p.436-441
Hauptverfasser: Akay, Fahrettin, Gündoğan, Fatih C., Yolcu, Umit, Toyran, Sami, Tunç, Elif, Uzun, Salih
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container_end_page 441
container_issue 5
container_start_page 436
container_title European journal of ophthalmology
container_volume 26
creator Akay, Fahrettin
Gündoğan, Fatih C.
Yolcu, Umit
Toyran, Sami
Tunç, Elif
Uzun, Salih
description Purpose To assess retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), and macular thickness changes in young adults with systemic arterial hypertension. Methods This study included 80 young patients (age 23.8 ± 2.8 years) with systemic hypertension (sHT) without any known systemic or ocular disease and 80 age-matched (23.5 ± 2.1 years) healthy controls. Retinal nerve fiber layer thickness, macular thickness, and GCC thickness were measured with spectral-domain optical coherence tomography. Results Mean disease duration was 3.45 ± 1.48 years (range 2-10). Differences in intraocular pressure, body mass index, axial length, and spherical equivalent between the groups were insignificant (p>0.05). The differences in RNFL thickness did not differ between the groups. Patients with sHT had significantly lower central macular thickness (p = 0.037), inner superior macular thickness (p = 0.045), and outer temporal superior and outer temporal inferior GCC (p0.05). Systolic and diastolic blood pressure were significantly correlated with inner temporal superior and inner temporal inferior GCC thickness in a negative manner (p
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Methods This study included 80 young patients (age 23.8 ± 2.8 years) with systemic hypertension (sHT) without any known systemic or ocular disease and 80 age-matched (23.5 ± 2.1 years) healthy controls. Retinal nerve fiber layer thickness, macular thickness, and GCC thickness were measured with spectral-domain optical coherence tomography. Results Mean disease duration was 3.45 ± 1.48 years (range 2-10). Differences in intraocular pressure, body mass index, axial length, and spherical equivalent between the groups were insignificant (p&gt;0.05). The differences in RNFL thickness did not differ between the groups. Patients with sHT had significantly lower central macular thickness (p = 0.037), inner superior macular thickness (p = 0.045), and outer temporal superior and outer temporal inferior GCC (p&lt;0.001 for both). The RNFL thickness did not differ significantly in all quadrants between the groups (p&gt;0.05). Systolic and diastolic blood pressure were significantly correlated with inner temporal superior and inner temporal inferior GCC thickness in a negative manner (p&lt;0.05 for all). Conclusions Ganglion cell complex thickness decrease is possibly a better retinal marker for hypertensive changes with respect to RNFL and macular thickness.</description><identifier>ISSN: 1120-6721</identifier><identifier>EISSN: 1724-6016</identifier><identifier>DOI: 10.5301/ejo.5000740</identifier><identifier>PMID: 26951532</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Blood Pressure - physiology ; Case-Control Studies ; Female ; Humans ; Hypertension - physiopathology ; Male ; Nerve Fibers - pathology ; Prospective Studies ; Retinal Ganglion Cells - pathology ; Tomography, Optical Coherence - methods ; Young Adult</subject><ispartof>European journal of ophthalmology, 2016-09, Vol.26 (5), p.436-441</ispartof><rights>2016 SAGE Publications</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c322t-cde620d467b8ba950d0987ab97471e79f4ddacd2b73578cadc2e0a4c82d64033</citedby><cites>FETCH-LOGICAL-c322t-cde620d467b8ba950d0987ab97471e79f4ddacd2b73578cadc2e0a4c82d64033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.5301/ejo.5000740$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.5301/ejo.5000740$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26951532$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akay, Fahrettin</creatorcontrib><creatorcontrib>Gündoğan, Fatih C.</creatorcontrib><creatorcontrib>Yolcu, Umit</creatorcontrib><creatorcontrib>Toyran, Sami</creatorcontrib><creatorcontrib>Tunç, Elif</creatorcontrib><creatorcontrib>Uzun, Salih</creatorcontrib><title>Retinal Structural Changes in Systemic Arterial Hypertension: An OCT Study</title><title>European journal of ophthalmology</title><addtitle>Eur J Ophthalmol</addtitle><description>Purpose To assess retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), and macular thickness changes in young adults with systemic arterial hypertension. Methods This study included 80 young patients (age 23.8 ± 2.8 years) with systemic hypertension (sHT) without any known systemic or ocular disease and 80 age-matched (23.5 ± 2.1 years) healthy controls. Retinal nerve fiber layer thickness, macular thickness, and GCC thickness were measured with spectral-domain optical coherence tomography. Results Mean disease duration was 3.45 ± 1.48 years (range 2-10). Differences in intraocular pressure, body mass index, axial length, and spherical equivalent between the groups were insignificant (p&gt;0.05). The differences in RNFL thickness did not differ between the groups. Patients with sHT had significantly lower central macular thickness (p = 0.037), inner superior macular thickness (p = 0.045), and outer temporal superior and outer temporal inferior GCC (p&lt;0.001 for both). The RNFL thickness did not differ significantly in all quadrants between the groups (p&gt;0.05). Systolic and diastolic blood pressure were significantly correlated with inner temporal superior and inner temporal inferior GCC thickness in a negative manner (p&lt;0.05 for all). 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Methods This study included 80 young patients (age 23.8 ± 2.8 years) with systemic hypertension (sHT) without any known systemic or ocular disease and 80 age-matched (23.5 ± 2.1 years) healthy controls. Retinal nerve fiber layer thickness, macular thickness, and GCC thickness were measured with spectral-domain optical coherence tomography. Results Mean disease duration was 3.45 ± 1.48 years (range 2-10). Differences in intraocular pressure, body mass index, axial length, and spherical equivalent between the groups were insignificant (p&gt;0.05). The differences in RNFL thickness did not differ between the groups. Patients with sHT had significantly lower central macular thickness (p = 0.037), inner superior macular thickness (p = 0.045), and outer temporal superior and outer temporal inferior GCC (p&lt;0.001 for both). The RNFL thickness did not differ significantly in all quadrants between the groups (p&gt;0.05). Systolic and diastolic blood pressure were significantly correlated with inner temporal superior and inner temporal inferior GCC thickness in a negative manner (p&lt;0.05 for all). Conclusions Ganglion cell complex thickness decrease is possibly a better retinal marker for hypertensive changes with respect to RNFL and macular thickness.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>26951532</pmid><doi>10.5301/ejo.5000740</doi><tpages>6</tpages></addata></record>
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subjects Adult
Blood Pressure - physiology
Case-Control Studies
Female
Humans
Hypertension - physiopathology
Male
Nerve Fibers - pathology
Prospective Studies
Retinal Ganglion Cells - pathology
Tomography, Optical Coherence - methods
Young Adult
title Retinal Structural Changes in Systemic Arterial Hypertension: An OCT Study
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