Retinal Structural Changes in Systemic Arterial Hypertension: An OCT Study
Purpose To assess retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), and macular thickness changes in young adults with systemic arterial hypertension. Methods This study included 80 young patients (age 23.8 ± 2.8 years) with systemic hypertension (sHT) without any known systemic or ocul...
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Veröffentlicht in: | European journal of ophthalmology 2016-09, Vol.26 (5), p.436-441 |
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creator | Akay, Fahrettin Gündoğan, Fatih C. Yolcu, Umit Toyran, Sami Tunç, Elif Uzun, Salih |
description | Purpose
To assess retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), and macular thickness changes in young adults with systemic arterial hypertension.
Methods
This study included 80 young patients (age 23.8 ± 2.8 years) with systemic hypertension (sHT) without any known systemic or ocular disease and 80 age-matched (23.5 ± 2.1 years) healthy controls. Retinal nerve fiber layer thickness, macular thickness, and GCC thickness were measured with spectral-domain optical coherence tomography.
Results
Mean disease duration was 3.45 ± 1.48 years (range 2-10). Differences in intraocular pressure, body mass index, axial length, and spherical equivalent between the groups were insignificant (p>0.05). The differences in RNFL thickness did not differ between the groups. Patients with sHT had significantly lower central macular thickness (p = 0.037), inner superior macular thickness (p = 0.045), and outer temporal superior and outer temporal inferior GCC (p0.05). Systolic and diastolic blood pressure were significantly correlated with inner temporal superior and inner temporal inferior GCC thickness in a negative manner (p |
doi_str_mv | 10.5301/ejo.5000740 |
format | Article |
fullrecord | <record><control><sourceid>sage_cross</sourceid><recordid>TN_cdi_crossref_primary_10_5301_ejo_5000740</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.5301_ejo.5000740</sage_id><sourcerecordid>10.5301_ejo.5000740</sourcerecordid><originalsourceid>FETCH-LOGICAL-c322t-cde620d467b8ba950d0987ab97471e79f4ddacd2b73578cadc2e0a4c82d64033</originalsourceid><addsrcrecordid>eNptkL9PwzAQhS0EoqUwsaOMSCjlfHHshK2K-KlKlWj3yLGvJVWbVHYy5L_HqIWJ6Z5033vDx9gth2maAH-kbTtNAUAJOGNjrlDEErg8D5kjxFIhH7Er77cACLnASzZCmac8TXDMPj6pqxu9i5ad603XuxCLL91syEd1Ey0H39G-NtHMdeTq8HwbDhRy4-u2eYpmTbQoVqHc2-GaXaz1ztPN6U7Y6uV5VbzF88XrezGbxyZB7GJjSSJYIVWVVTpPwUKeKV3lSihOKl8La7WxWKkkVZnR1iCBFiZDKwUkyYQ9HGeNa713tC4Prt5rN5Qcyh8hZRBSnoQE-u5IH_pqT_aP_TUQgPsj4PWGym3bu2DD_7v1DXkRaGQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Retinal Structural Changes in Systemic Arterial Hypertension: An OCT Study</title><source>SAGE Complete A-Z List</source><source>MEDLINE</source><creator>Akay, Fahrettin ; Gündoğan, Fatih C. ; Yolcu, Umit ; Toyran, Sami ; Tunç, Elif ; Uzun, Salih</creator><creatorcontrib>Akay, Fahrettin ; Gündoğan, Fatih C. ; Yolcu, Umit ; Toyran, Sami ; Tunç, Elif ; Uzun, Salih</creatorcontrib><description>Purpose
To assess retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), and macular thickness changes in young adults with systemic arterial hypertension.
Methods
This study included 80 young patients (age 23.8 ± 2.8 years) with systemic hypertension (sHT) without any known systemic or ocular disease and 80 age-matched (23.5 ± 2.1 years) healthy controls. Retinal nerve fiber layer thickness, macular thickness, and GCC thickness were measured with spectral-domain optical coherence tomography.
Results
Mean disease duration was 3.45 ± 1.48 years (range 2-10). Differences in intraocular pressure, body mass index, axial length, and spherical equivalent between the groups were insignificant (p>0.05). The differences in RNFL thickness did not differ between the groups. Patients with sHT had significantly lower central macular thickness (p = 0.037), inner superior macular thickness (p = 0.045), and outer temporal superior and outer temporal inferior GCC (p<0.001 for both). The RNFL thickness did not differ significantly in all quadrants between the groups (p>0.05). Systolic and diastolic blood pressure were significantly correlated with inner temporal superior and inner temporal inferior GCC thickness in a negative manner (p<0.05 for all).
Conclusions
Ganglion cell complex thickness decrease is possibly a better retinal marker for hypertensive changes with respect to RNFL and macular thickness.</description><identifier>ISSN: 1120-6721</identifier><identifier>EISSN: 1724-6016</identifier><identifier>DOI: 10.5301/ejo.5000740</identifier><identifier>PMID: 26951532</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Blood Pressure - physiology ; Case-Control Studies ; Female ; Humans ; Hypertension - physiopathology ; Male ; Nerve Fibers - pathology ; Prospective Studies ; Retinal Ganglion Cells - pathology ; Tomography, Optical Coherence - methods ; Young Adult</subject><ispartof>European journal of ophthalmology, 2016-09, Vol.26 (5), p.436-441</ispartof><rights>2016 SAGE Publications</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c322t-cde620d467b8ba950d0987ab97471e79f4ddacd2b73578cadc2e0a4c82d64033</citedby><cites>FETCH-LOGICAL-c322t-cde620d467b8ba950d0987ab97471e79f4ddacd2b73578cadc2e0a4c82d64033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.5301/ejo.5000740$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.5301/ejo.5000740$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26951532$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akay, Fahrettin</creatorcontrib><creatorcontrib>Gündoğan, Fatih C.</creatorcontrib><creatorcontrib>Yolcu, Umit</creatorcontrib><creatorcontrib>Toyran, Sami</creatorcontrib><creatorcontrib>Tunç, Elif</creatorcontrib><creatorcontrib>Uzun, Salih</creatorcontrib><title>Retinal Structural Changes in Systemic Arterial Hypertension: An OCT Study</title><title>European journal of ophthalmology</title><addtitle>Eur J Ophthalmol</addtitle><description>Purpose
To assess retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), and macular thickness changes in young adults with systemic arterial hypertension.
Methods
This study included 80 young patients (age 23.8 ± 2.8 years) with systemic hypertension (sHT) without any known systemic or ocular disease and 80 age-matched (23.5 ± 2.1 years) healthy controls. Retinal nerve fiber layer thickness, macular thickness, and GCC thickness were measured with spectral-domain optical coherence tomography.
Results
Mean disease duration was 3.45 ± 1.48 years (range 2-10). Differences in intraocular pressure, body mass index, axial length, and spherical equivalent between the groups were insignificant (p>0.05). The differences in RNFL thickness did not differ between the groups. Patients with sHT had significantly lower central macular thickness (p = 0.037), inner superior macular thickness (p = 0.045), and outer temporal superior and outer temporal inferior GCC (p<0.001 for both). The RNFL thickness did not differ significantly in all quadrants between the groups (p>0.05). Systolic and diastolic blood pressure were significantly correlated with inner temporal superior and inner temporal inferior GCC thickness in a negative manner (p<0.05 for all).
Conclusions
Ganglion cell complex thickness decrease is possibly a better retinal marker for hypertensive changes with respect to RNFL and macular thickness.</description><subject>Adult</subject><subject>Blood Pressure - physiology</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Nerve Fibers - pathology</subject><subject>Prospective Studies</subject><subject>Retinal Ganglion Cells - pathology</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Young Adult</subject><issn>1120-6721</issn><issn>1724-6016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkL9PwzAQhS0EoqUwsaOMSCjlfHHshK2K-KlKlWj3yLGvJVWbVHYy5L_HqIWJ6Z5033vDx9gth2maAH-kbTtNAUAJOGNjrlDEErg8D5kjxFIhH7Er77cACLnASzZCmac8TXDMPj6pqxu9i5ad603XuxCLL91syEd1Ey0H39G-NtHMdeTq8HwbDhRy4-u2eYpmTbQoVqHc2-GaXaz1ztPN6U7Y6uV5VbzF88XrezGbxyZB7GJjSSJYIVWVVTpPwUKeKV3lSihOKl8La7WxWKkkVZnR1iCBFiZDKwUkyYQ9HGeNa713tC4Prt5rN5Qcyh8hZRBSnoQE-u5IH_pqT_aP_TUQgPsj4PWGym3bu2DD_7v1DXkRaGQ</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Akay, Fahrettin</creator><creator>Gündoğan, Fatih C.</creator><creator>Yolcu, Umit</creator><creator>Toyran, Sami</creator><creator>Tunç, Elif</creator><creator>Uzun, Salih</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20160901</creationdate><title>Retinal Structural Changes in Systemic Arterial Hypertension: An OCT Study</title><author>Akay, Fahrettin ; Gündoğan, Fatih C. ; Yolcu, Umit ; Toyran, Sami ; Tunç, Elif ; Uzun, Salih</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c322t-cde620d467b8ba950d0987ab97471e79f4ddacd2b73578cadc2e0a4c82d64033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Blood Pressure - physiology</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>Nerve Fibers - pathology</topic><topic>Prospective Studies</topic><topic>Retinal Ganglion Cells - pathology</topic><topic>Tomography, Optical Coherence - methods</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akay, Fahrettin</creatorcontrib><creatorcontrib>Gündoğan, Fatih C.</creatorcontrib><creatorcontrib>Yolcu, Umit</creatorcontrib><creatorcontrib>Toyran, Sami</creatorcontrib><creatorcontrib>Tunç, Elif</creatorcontrib><creatorcontrib>Uzun, Salih</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>European journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akay, Fahrettin</au><au>Gündoğan, Fatih C.</au><au>Yolcu, Umit</au><au>Toyran, Sami</au><au>Tunç, Elif</au><au>Uzun, Salih</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinal Structural Changes in Systemic Arterial Hypertension: An OCT Study</atitle><jtitle>European journal of ophthalmology</jtitle><addtitle>Eur J Ophthalmol</addtitle><date>2016-09-01</date><risdate>2016</risdate><volume>26</volume><issue>5</issue><spage>436</spage><epage>441</epage><pages>436-441</pages><issn>1120-6721</issn><eissn>1724-6016</eissn><abstract>Purpose
To assess retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), and macular thickness changes in young adults with systemic arterial hypertension.
Methods
This study included 80 young patients (age 23.8 ± 2.8 years) with systemic hypertension (sHT) without any known systemic or ocular disease and 80 age-matched (23.5 ± 2.1 years) healthy controls. Retinal nerve fiber layer thickness, macular thickness, and GCC thickness were measured with spectral-domain optical coherence tomography.
Results
Mean disease duration was 3.45 ± 1.48 years (range 2-10). Differences in intraocular pressure, body mass index, axial length, and spherical equivalent between the groups were insignificant (p>0.05). The differences in RNFL thickness did not differ between the groups. Patients with sHT had significantly lower central macular thickness (p = 0.037), inner superior macular thickness (p = 0.045), and outer temporal superior and outer temporal inferior GCC (p<0.001 for both). The RNFL thickness did not differ significantly in all quadrants between the groups (p>0.05). Systolic and diastolic blood pressure were significantly correlated with inner temporal superior and inner temporal inferior GCC thickness in a negative manner (p<0.05 for all).
Conclusions
Ganglion cell complex thickness decrease is possibly a better retinal marker for hypertensive changes with respect to RNFL and macular thickness.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>26951532</pmid><doi>10.5301/ejo.5000740</doi><tpages>6</tpages></addata></record> |
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source | SAGE Complete A-Z List; MEDLINE |
subjects | Adult Blood Pressure - physiology Case-Control Studies Female Humans Hypertension - physiopathology Male Nerve Fibers - pathology Prospective Studies Retinal Ganglion Cells - pathology Tomography, Optical Coherence - methods Young Adult |
title | Retinal Structural Changes in Systemic Arterial Hypertension: An OCT Study |
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